Aqueous solution for preserving tissues and organs 机翻标题: 暂无翻译,请尝试点击翻译按钮。

公开号/公开日
WO200069259 A1 2000-11-23 [WO200069259] / 2000-11-23
申请号/申请日
2000WO-FR01336 / 2000-05-18
发明人
LOPEZ GEORGES ANTOINE;RAMELLA VIRIEUX SILVINA;
申请人
CAIR L G L;
主分类号
IPC分类号
A01N-001/02
摘要
(WO200069259) The invention relates to an aqueous solution for preserving tissues and organs, characterized in that it is an extracellular-type solution and in that it contains calcium ions (Ca<2+>) and purified polyethylene glycol with a molecular weight of 35 000.
机翻摘要
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地址
代理人
代理机构
;
优先权号
1999FR-0006434 1999-05-18
主权利要求
(WO200069259) REVENDICATIONS 1/ Solution aqueuse de conservation de tissus et d'organes, caractérisée en ce qu'elle est du type extracellulaire et en ce qu'elle comprend des ions calcium (Ca2+) et du polyethylene glycol purifié de poids moléculaire égal à 35 000. 2/ Solution aqueuse selon la revendication 1, caractérisée en ce que le PEG est synthétisé à partir de molécules de PEG de poids moléculaire inférieur. 3/ Solution aqueuse selon l'une des revendications précédentes, caractérisée en ce qu'elle comprend des ions Na+à une concentration d'au moins 30 millimoles, avantageusement 125 millimoles. 4/ Solution aqueuse selon l'une des revendications précédentes, caractérisée en ce que la concentration en ion Ca2+est comprise entre 0,01 et 2 millimoles, avantageusement 0,5 millimole. 51 Solution aqueuse de conservation selon l'une des revendications précédentes, caractérisée en ce que la concentration de PEG dans la solution est comprise entre 0,01 et 5 millimoles, de préférence inférieure à 1 millimole, avantageusement égale à 0,03 millimole. 6/ Solution aqueuse de conservation selon l'une des revendications précédentes, caractérisée en ce qu'elle comprend en outre un anion imperméant, un sucre, un agent stabilisant de membrane, une solution tampon, un agent antiradicalaire et une source d'énergie. Il Solution aqueuse de conservation selon l'une des revendications précédentes, caractérisée en ce qu'elle comprend en outre : - de 20 à 40 millimoles de raffinose, - de 70 à 140 millimoles d'acide lactobionique, - de 1 à 10 millimoles de MgS04, - de 10 à 40 millimoles de H2P04apporté par KH2P04, - de 1 à 6 millimoles de Glutathion, - de 1 à 10 millimoles d'Adénosine, - de 1,5 à 5 millimoles d'Allopurinol, - de 10 à 40 millimoles de K+apportées par KH2P04, - de 30 à 150 millimoles de Na+apportées par NaOH, - avec pH = 6,5 à 8 - et osmolarité de 290 à 320 millimoles/kg 8/ Solution aqueuse de conservation selon l'une des revendications précédentes, caractérisée en ce qu'elle comprend : Raffinose 30 millimoles PEG 35000 purifié 0,03 millimoles MgS045 millimoles H2P0425 millimoles CaCl20,5 millimoles Gluthation 3 millimoles Adénosine 5 millimoles Allopurinol 1 millimole Na+(apporté par NaOH) 125 millimoles K+(apporté par KH2P04) 25 millimoles pH = 7,4 osmolarité 300 millimoles/kg
法律状态
(WO200069259) LEGAL DETAILS FOR WO200069259  Actual or expected expiration date=2002-11-18    Legal state=DEAD    Status=LAPSED     Event publication date=2000-05-18  Event code=WO/APP  Event indicator=Pos  Event type=Examination events  Application details  Application country=WO WOFR0001336  Application date=2000-05-18  Standardized application number=2000WO-FR01336     Event publication date=2000-11-23  Event code=WO/A1  Event type=Examination events  Published application with search report  Publication country=WO  Publication number=WO200069259  Publication stage Code=A1  Publication date=2000-11-23  Standardized publication number=WO200069259     Event publication date=2000-11-23  Event code=WO/AK  Event indicator=Pos  Event type=Designated states  Designated states AE AG AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW    Event publication date=2000-11-23  Event code=WO/AL  Event indicator=Pos  Event type=Designated states  Designated countries for regional patents GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG    Event publication date=2001-02-22  Event code=WO/DFPE  Event type=Examination events  Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)    Event publication date=2002-11-18  Event code=WO/EETL  Event type=Event indicating Not In Force  PCT Application validity period expired. LEGAL DETAILS FOR DESIGNATED STATE AT233483  Actual or expected expiration date=2020-05-18    Legal state=ALIVE    Status=GRANTED   Corresponding cc:  Designated or member state=AT Corresponding appl: AT00927362  Application date in the designated or member state=2000-05-18   Application number in the designated or member state=2000AT-0927362T Corresponding cc:  Designated or member state=AT Corresponding pat: AT233483  Publication stage code in the designated or member state=T  Publication date in the designated or member state=2003-03-15   Publication number in the designated or member state=ATE233483    Event publication date=2003-07-15  Event code=AT/STCHG  Patent Status changed by the national office Corresponding cc:  Designated or member state=AT  LEGAL DETAILS FOR DESIGNATED STATE AU4577100  Actual or expected expiration date=2020-05-18    Legal state=ALIVE    Status=GRANTED   Corresponding cc:  Designated or member state=AU Corresponding appl: AU4577100  Application date in 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been informed by wipo that ep was designated in this application Corresponding cc:  Designated or member state=EP     Event publication date=2001-10-20  Event code=WO/WWE  Event indicator=Pos  Event type=Entry into national phase  Wipo information: entry into national phase Corresponding cc:  Designated or member state=EP     Event publication date=2002-02-13  Event code=WO/WWP  Event indicator=Pos  Event type=Examination events  Wipo information: published in national office Corresponding cc:  Designated or member state=EP     Event publication date=2003-03-05  Event code=WO/WWG  Event indicator=Pos  Event type=Event indicating In Force  Wipo information: grant in national office Corresponding cc:  Designated or member state=EP  LEGAL DETAILS FOR DESIGNATED STATE JP  Actual or expected expiration date=2004-02-23    Legal state=DEAD    Status=LAPSED   Corresponding cc:  Designated or member state=JP     Event publication date=2004-02-23  Event code=WO/NENP  Event type=Event indicating 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专利类型码
A1
国别省市代码
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