Pest-control compositions and methods having high target and low non-target activity 机翻标题: 暂无翻译,请尝试点击翻译按钮。

公开号/公开日
CA2731654 A1 2010-01-28 [CA2731654] / 2010-01-28
申请号/申请日
2009CA-2731654 / 2009-07-22
发明人
ENAN ESSAM;
申请人
TYRATECH;
主分类号
IPC分类号
A01N-025/00
摘要
(CA2731654) Embodiments of the invention relate to compositions and methods for selective pest control wherein the compositions include active agents that in combination have a first activity against a selected target pest and a second activity against a selected non-target organism and wherein the first activity is greater than the second.  Further embodiments of the invention relate to a method for developing selective pest control compositions and low-resistance pest control compositions.
机翻摘要
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地址
代理人
代理机构
;
优先权号
2008US-61082601 2008-07-22 2009WO-US51457 2009-07-22
主权利要求
(CA2731654)  What is claimed is: 1. A selective pest-control composition having at least two active agents, wherein the active agents in combination have a first activity against a selected target pest, and wherein the active agents in combination have a second activity against a selected non-target organism, and wherein the first activity is greater than the second activity. 2. The selective pest-control composition of Claim 1 wherein the first activity is at least 2 times greater than the second activity. 3. The selective pest-control composition of Claim 1 wherein the first activity is at least 10 times greater than the second activity. 4. The selective pest-control composition of Claim 1 wherein the first activity is at least 20 times greater than the second activity. 5. The selective pest-control composition of Claim 1 wherein the first activity is at least 50 times greater than the second activity. 6. The selective pest-control composition of Claim 1 wherein the first activity is at least 100 times greater than the second activity. 7. The selective pest control compostion of Claim 1, wherein the first activity results from interaction of the composition with at least one biological target that is substantially absent in the non-target organism. 8. The selective pest control composition of Claim 1, wherein the non-target organism is selected from the group consisting of vertebrate animals and plants. 9. The selective pest control composition of Claim 8, wherein the non-target organism is a vertebrate animal, the ratio of the first activity to the second activity is expressed as a ratio of LD50(target) to LD50(vertebrate animal), and the ratio is less than 0.1. 10. The selective pest control compostion of Claim 1, wherein the first activity results from interaction of the composition with at least one biological target that is present in the non-target organism. 11. The selective pest control composition of Claim 7 or Claim 10, wherein the biological target is a G protein-coupled receptor. 12. The composition of Claim 11, wherein the G-protein coupled receptor is selected from the group consisting of a tyramine receptor, an octopamine receptor, olfactory receptor Gr83b, and olfactory receptor 43a. 13. The selective pest-control composition of one of Claims 1-10, wherein the active agents have a synergistic activity in the target pest. 14. The selective pest-control composition of one of Claims 1-10, wherein the active agents have a non-synergistic activity in the non-target organism. 15. The selective pest-control composition of one of Claims 1-10, wherein the active agents have antagonistic activity with respect to one another in the non-target organism. 16. A method of selective pest control comprising contacting a target pest with a composition comprising at least two active agents, wherein the active agents in combination have a first activity against the target pest, and a second activity against a nontarget organism, and wherein the first activity is 10 times greater than the second activity. 17. A method of developing a selective pest control composition, comprising the steps of, selecting a target pest for selective control by the composition, and a nontarget organism to be substantially unaffected by the composition;  identifying at least two active agents for the composition, wherein the active agents in combination have a complementary effect within the target pest;  and confirming that the identified active agents do not have a complementary effect within the non-target organism, to establish that the composition is selective of the target pest over the non-target organism. 18. The method of claim 17, wherein the complementary effect comprises a synergistic effect of the active agents together as compared with an effect of each active agent separately. 19. The method of claim 17, wherein the confirming step comprises confirming that the agents in combination have an effect in the non-target organism selected from the group consisting of: an antagonistic effect, a non-additive effect, and an additive effect. 20. A method of developing a low-resistance pest control formulation against a target pest, comprising the steps of: selecting a target pest, the pest having at least a first and a second molecular target, where the molecular targets are under genetic control;  selecting at least two active agents, wherein a first active agent interacts with the first molecular target under genetic control and a second active agent interacts with the second molecular target under genetic control;  and combining the two active agents in a formulation, wherein the agents in the formulation act upon the target pest in a complementary manner, and wherein resistance to the formulation in an individual target pest requires two separate genetic lesions divergent from a non-resistant population of the pest. 21. The method of Claim 20, wherein the first and second molecular targets comprise two separate molecules encoded or controlled by separate first and second genetic elements. 22. The method of Claim 20, wherein the first molecular target is controlled by a first genetic element encoding a protein, the second molecular target is controlled by a second genetic element encoding a protein, and the two separate genetic lesions comprise a lesion in the first genetic element and a lesion in the second genetic element.  23 The method of Claim 21, wherein the first molecular target is a cellular entity, the second molecular target is a cellular entity, and the two separate genetic lesions comprise a lesion in the first genetic element and a lesion in the second genetic element. 24. The method of Claim 20, wherein the first and second molecular targets comprise two separate portions of a single molecule encoded or controlled by a single genetic element, and wherein the two separate portions are at a distance from each other such that conversion of each of the two separate portions to a resistant form would require two separate genetic lesions within the single genetic element. 25. The method of claim 20, wherein the complementary manner comprises a synergistic effect as compared with each agent acting separately.
法律状态
(CA2731654) LEGAL DETAILS FOR CA2731654  Actual or expected expiration date=2013-07-23    Legal state=DEAD    Status=LAPSED     Event publication date=2009-07-22  Event code=CA/APP  Event indicator=Pos  Event type=Examination events  Application details  Application country=CA CA2731654  Application date=2009-07-22  Standardized application number=2009CA-2731654     Event publication date=2010-01-28  Event code=CA/A1  Event type=Examination events  Application laid open  Publication country=CA  Publication number=CA2731654  Publication stage Code=A1  Publication date=2010-01-28  Standardized publication number=CA2731654     Event publication date=2013-09-18  Event code=CA/FZDE  Event indicator=Neg  Event type=Event indicating Not In Force  Dead  Effective date of the event=2013-07-23
专利类型码
A1
国别省市代码
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