Novel substituted 1H - dihydropyrazole, their preparation and use 机翻标题: 暂无翻译,请尝试点击翻译按钮。

源语言标题
(JP4448327) 新規​置換​1​H-ジヒドロピラゾール、それら​の​製造​および​使用
公开号/公开日
JP2005507873 A 2005-03-24 [JP2005507873]JP4448327 B2 2010-04-07 [JP4448327] / 2005-03-242010-04-07
申请号/申请日
2003JP-0521208 / 2002-08-13
发明人
Anise Gary Deibitsudo;Lahm Jiyoji-Fuiritsupu;Selby Paul Thomas;Suteibunson Thomas Matein;
申请人
DU PONT DE NEMOURS;
主分类号
IPC分类号
A01N-043/56A61K-031/4152A61K-031/4439C07C-249/16C07C-251/76C07D-213/77C07D-231/06C07D-231/08C07D-231/14C07D-231/16C07D-231/44C07D-401/04C07D-403/04C07D-413/04C07D-413/14
摘要
(JP4448327) This invention provides compounds of Formula I, methods for their preparation and use for preparing compounds of Formula II wherein R1, R2, R3, R5, R6, X and n are as defined in the disclosure.  This invention also discloses preparation of compounds of Formula III wherein R1, R2, R7, R8, R9 and n are as defined in the disclosure.  This invention also pertains to certain compounds of Formula 4 and 6 used to prepare compounds of Formula I. wherein R1, R2, R5, X and n are as defined in the disclosure.  (From US7932395 B2)
机翻摘要
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地址
代理人
代理机构
;
优先权号
2001US-60311919 2001-08-13 2001US-60341894 2001-12-19 2002US-60369659 2002-04-02 2002WO-US25612 2002-08-13
主权利要求
(JP4448327) 1. Of the formula I  [xLxWx, R1 H is, C1 -C6 alkyl, C2 -C6 alkenyl, C2 -C6 alkynyl, C3 -C6 Cycloalkjd, C1 -C6 haloalkyl, C2 -C6 haloalkenyl, C2 -C6 haloalkynyl or C3 -C6 and halocycloalkyl, each R2 independently C1 -C4 alkyl, C2 -C4 alkenyl, C2 -C4 alkynyl, C3 -C6 Cycloalkjd, C1 -C4 haloalkyl, C2 -C4 haloalkenyl, C2 -C4 haloalkynyl, C3 -C6 halocycloalkyl, halogen, CN, NO2 、C1 -C4 alkoxy, C1 -C4 haloalkoxy, C1 -C4 alkylthio, C1 -C4 alkylsulfinyl, C1 -C4 Examptes, C1 -C4 alkylamino, C2 -C8 dialkylamino, C3 -C6 cycloalkylamino, C3 -C6 (alkyl) cycloalkylamino, C2 -C4 alkylcarbonyl, C2 -C6 alkoxycarbonyl, C2 -C6 alkylaminocarbonyl, C3 -C8 dialkylaminocarbonyl or C3 -C6 is trialkylsilyl, R3 H is, C1 -C4 alkyl, C2 -C4 alkylcarbonyl or C2 -C6 and alkoxycarbonyl, or is X N CR4 and, R4 is H or R2 and, R5 is C1 -C4 alkyl and, when n is 0-3 and, however, that when X CH, in which n is at least 1] of the compound. 2. Of the formula6  [˜C, R 1 H is, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 6 Cycloalkjd, C 1 -C 6 haloalkylinclude, C 2 -C 6 haloalkenyl, C 2 -C 6 haloalkynyl or C 3 -C 6 and halocycloalkyl, each R 2 independently C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 3 -C 6 Cycloalkjd, C 1 -C 4 haloalkylinclude, C 2 -C 4 haloalkenyl, C 2 -C 4 haloalkynyl, C 3 -C 6 halocycloalkyl, halogen, CN, NO 2 、C 1 -C 4 alkoxy, C 1 -C 4 haloalkoxy, C 1 -C 4 alkylthio, C 1 -C 4 alkylsulfinyl, C 1 -C 4 Examptes, C 1 -C 4 alkylamino, C 2 -C 8 dialkylamino, C 3 -C 6 cycloalkylamino, C 3 -C 6 (alkyl) cycloalkylamino, C 2 -C 4 alkylcarbonyl, C 2 -C 6 ofPreferred, C 2 -C 6 alkylaminocarbonyl, C 3 -C 8 dialkylaminocarbonyl or C 3 -C 6 is trialkylsilyl, XN or is CR 4 and, R 4 is H or R 2 and, R 5 is C 1 -C 4 alkyl, then nis 0-3 in which, however, that when X CH, n is at least 1]compound with base, intermediate of the formula Ia  [˜C, M + is derived from a base and a suitable counter-ions, then X, R 1 、R 2 、R 5 and n are as defined are as described above] formed,overdub R3 is C1 -C4 alkyl, C2 -C4 alkylcarbonyl or C2 -C6 when ofPreferred 、WARukokishido counter ion R3 to replace the appropriate alkylating agent or acylating agent is reacted, thereby producing a compound of formula and I fit, or R 3 H if the, and protonated with a suitable acid, to give a compound of the formula Icomprising preparation of a compound of the formula according to claim 1 I.  3. Of the formula II  [xLxWx, R 1 H is, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 6 cycloalkyl, C 1 -C 6 haloalkyl, C 2 -C 6 haloalkenyl, C 2 -C 6 haloalkynyl or C 3 -C 6 and halocycloalkyl, each R 2 independently C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 3 -C 6 cycloalkyl, C 1 -C 4 haloalkyl, C 2 -C 4 haloalkenyl, C 2 -C 4 haloalkynyl, C 3 -C 6 halocycloalkyl, halogen, CN, NO 2 、C 1 -C 4 alkoxy, C 1 -C 4 haloalkoxy, C 1 -C 4 alkylthio, C 1 -C 4 alkylsulfinyl, C 1 -C 4 Examptes, C 1 -C 4 alkylamino, C 2 -C 8 dialkylamino, C 3 -C 6 cycloalkylamino, C 3 -C 6 (alkyl) cycloalkylamino, C 2 -C 4 alkylcarbonyl, C 2 -C 6 ofPreferred, C 2 -C 6 alkylaminocarbonyl, C 3 -C 8 dialkylaminocarbonyl or C 3 -C 6 is trialkylsilyl, XN or is CR 4 and, R 4 is H or R 2 and, R 6 H or is C 1 -C 4 alkyl, then nis 0-3 in which, however, that when X CH, n is at least 1] method for the production of compounds,according to claim 1 treatment with acid a compound of the formula I and, R 6 is C 1 -C 4 alkyl to yield a compound of the formula II、overdub R6 H if the, R 6 is C 1 -C 4 II of a compound of formulaand converted, R6 H is of the formula IIofto give a compound of the formula II which comprises the preparation of compounds.   4. Of the formula II  [xLxWx, R1 is CF3 and, each R2 Cl or Br and is independently one of the 1 R2 is is in the 3, which is X N, R6 H or is C1 -C4 alkyl, and n is in the 0-3] of the compound.  5. R6 H and is, then n is 1 in the compound according to claim 4.
法律状态
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AB2
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