High-speed microwave assisted synthesis of SEA0400—a selective inhibitor of the Na~+/Ca~(2+)exchanger 机翻标题: 暂无翻译,请尝试点击翻译按钮。

来源
Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry
年/卷/期
2012 / 53 / 29
页码
3731-3734
ISSN号
0040-4039
作者单位
Christian Doppler Laboratory for Microwave Chemistry and Institute of Chemistry, Karl-Franzens-University Graz, Heinrichstrasse 28, A-8010 Graz, Austria;Institute of Biophysics, Medical University of Graz, Harrachgasse 21/IV, 8010 Graz, Austria;Christian Doppler Laboratory for Microwave Chemistry and Institute of Chemistry, Karl-Franzens-University Graz, Heinrichstrasse 28, A-8010 Graz, Austria;
作者
Gemma Guedes de la Cruz;Klaus Groschner;C. Oliver Kappe;
摘要
An efficient and rapid five-step synthesis of SEA0400, a selective Na~+/Ca~(2+) exchanger (NCX) inhibitor, using controlled microwave heating is reported. In addition, a novel three-step route omitting the key Baeyer-Villiger oxidation/hydrolysis sequence has been developed.
机翻摘要
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关键词/主题词
Baeyer-Villiger oxidation;Williamson ether synthesis;Microwave-assisted synthesis;Continuous-flow hydrogenation;Process intensification;SEA0400;
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