Compositions and methods for treating herpes simplex virus 机翻标题: 暂无翻译,请尝试点击翻译按钮。

公开号/公开日
US2012172423 A1 2012-07-05 [US20120172423] US9446017 B2 2016-09-20 [US9446017] / 2012-07-05 2016-09-20
申请号/申请日
2011US-13177041 / 2011-07-06
发明人
HSU STEPHEN D
申请人
AUGUSTA UNIVERSITY RESEARCH INSTITUTE;MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE
主分类号
IPC分类号
A01N-043/16;A61K-031/35;A61K-031/353
摘要
(US9446017)
Green tea polyphenol compositions and methods of their use in treating herpes simplex virus (HSV) are provided. 
Representative green tea polyphenols include, but are not limited to (−)-epigallocatechin-3-gallate as well as green tea polyphenols with one on more ester-linked fatty acids.
机翻摘要
暂无翻译结果,您可以尝试点击头部的翻译按钮。
地址
代理人
代理机构
优先权号
2005US-60707234 2005-08-11 2006WO-US31120 2006-08-10 2008US-12063139 2008-02-07 2010US-61361752 2010-07-06 2011US-13177041 2011-07-06
主权利要求
(US9446017)
I claim:
1. A method for treating herpes simplex virus (HSV) infection in a subject comprising administering to the subject a composition comprising 12.5 mu M to 100 mu M green tea polyphenol esterified with stearic or palmitic acid at the 4' position and glycerin to treat at least one symptom of HSV infection.
2. The method of claim 1, wherein the composition comprises 0.001% to about 50% w/v of the green tea polyphenol esterified with stearic or palmitic acid at the 4' position.
3. The method of claim 1 wherein the green tea polyphenol is (-)-epigallocatechin-3-gallate esterified at the 4' position with stearic acid.
4. The method of claim 1 wherein the subject is human.
5. The method of claim 1 wherein the composition further comprises an anesthetic.
6. The method of claim 1 wherein the composition is formulated for topical administration.
7. The method of claim 1, wherein the composition is formulated for oral administration.
8. The method of claim 1, wherein the green tea polyphenol is selected from the group consisting of (-)-epicatechin, (-)-epigallocatechin, (-)-epicatechin-3-gallate, enantiomers thereof, isomers thereof, and combinations thereof.
9. The method of claim 1, wherein the HSV is HSV-1.
10. The method of claim 1, wherein the green tea polyphenol is (-)-epigallocatechin -3-gallate esterified at the 4' position with palmitic acid.
法律状态
(US9446017)
LEGAL DETAILS FOR US2012172423

Actual or expected expiration date=2031-07-06   
Legal state=ALIVE   
Status=GRANTED 



Event publication date=2011-07-06 
Event code=US/APP 
Event indicator=Pos 
Event type=Examination events 
Application details

Application country=US US13177041 
Application date=2011-07-06 
Standardized application number=2011US-13177041 



Event publication date=2011-07-06 
Event code=US/EXMR 
Event type=Administrative notifications 
USPTO Examiner Name
Primary Examiner: CORNET, JEAN P



Event publication date=2011-07-06 
Event code=US/ART 
Event type=Administrative notifications 
USPTO Art Group

ART=1628 



Event publication date=2011-07-06 
Event code=US/SMALL 
Event type=Administrative notifications 
Appl Has Filed a Verified Statement of Micro to Small Entity Status
Business Entity Status: SMALL



Event publication date=2011-07-06 
Event code=US/AIA 
Event type=Administrative notifications 
First Inventor File Indicated:

AIA=No 



Event publication date=2011-07-06 
Event code=US/DK 
Event type=Examination events 
Attorney Docket Number
Docket Nbr: 064466.017CIP



Event publication date=2011-07-06 
Event code=US/CUST 
Event type=Examination events 
Attorney/Agent Customer Number
Customer Nbr: 25461



Event publication date=2011-07-19 
Event code=US/INCD 
Event type=Examination events 
Event type=OAO 
Notice Mailed--Application Incomplete--Filing Date Assigned



Event publication date=2011-07-19 
Event code=US/APPFILEREC 
Event type=Administrative notifications 
Event type=OAO 
Filing Receipt



Event publication date=2011-09-16 
Event code=US/AS 
Event type=Change of name or address 
Event type=Reassignment 
Assignment
Owner: GEORGIA HEALTH SCIENCES UNIVERSITY RESEARCH INSTIT

Effective date of the event=2011-07-19 
ASSIGNMENT OF ASSIGNORS INTEREST ASSIGNOR:HSU, STEPHEN D. REEL/FRAME:026918/0601 



Event publication date=2012-03-29 
Event code=US/RECEIPTUP 
Event type=Administrative notifications 
Event type=OAO 
Filing Receipt - Updated



Event publication date=2012-03-29 
Event code=US/POAC 
Event type=Change of name or address 
Change in Power of Attorney (May Include Associate POA)



Event publication date=2012-07-05 
Event code=US/A1 
Event type=Examination events 
Application published

Publication country=US 
Publication number=US2012172423 
Publication stage Code=A1 
Publication date=2012-07-05 
Standardized publication number=US20120172423 



Event publication date=2012-07-05 
Event code=US/PGPUBN 
Event indicator=Pos 
Event type=Examination events 
Event type=OAO 
PG-Pub Issue Notification



Event publication date=2012-07-09 
Event code=US/DOCK 
Event indicator=Pos 
Event type=Examination events 
Case Docketed to Examiner



Event publication date=2012-07-19 
Event code=US/DOCK 
Event indicator=Pos 
Event type=Examination events 
Case Docketed to Examiner



Event publication date=2012-08-10 
Event code=US/RESTREQ 
Event type=Examination events 
Event type=Corrections 
Event type=OAO 
Restriction/Election Requirement



Event publication date=2012-09-11 
Event code=US/ELC 
Event type=Examination events 
Event type=OAI 
Response to Election / Restriction Filed



Event publication date=2012-11-30 
Event code=US/CTNF 
Event type=Examination events 
Event type=OA 
Event type=OAO 
Non-Final Rejection



Event publication date=2013-02-05 
Event code=US/IDS 
Event type=Examination events 
Event type=OAI 
Information Disclosure Statement Filed



Event publication date=2013-04-02 
Event code=US/CTNFR 
Event type=Examination events 
Event type=OAI 
Response after Non-Final Action



Event publication date=2013-04-02 
Event code=US/136G 
Event type=OAO 
Request for Extension of Time - Granted



Event publication date=2013-05-09 
Event code=US/IDS 
Event type=Examination events 
Event type=OAI 
Information Disclosure Statement Filed



Event publication date=2013-06-24 
Event code=US/CTFR 
Event type=Examination events 
Event type=OA 
Event type=OAO 
Final Rejection



Event publication date=2013-11-18 
Event code=US/RCEX 
Event type=Examination events 
Event type=RCE 
Event type=OAI 
Request for Continued Examination (RCE)



Event publication date=2013-11-18 
Event code=US/136G 
Event type=OAO 
Request for Extension of Time - Granted



Event publication date=2013-11-19 
Event code=US/DRCECAP 
Event type=RCE 
Event type=OAO 
Disposal for a RCE / CPA / R129



Event publication date=2014-06-16 
Event code=US/CTNF 
Event type=Examination events 
Event type=OA 
Event type=OAO 
Non-Final Rejection



Event publication date=2014-12-29 
Event code=US/136G 
Event type=OAO 
Request for Extension of Time - Granted



Event publication date=2014-12-29 
Event code=US/CTNFR 
Event type=Examination events 
Event type=OAI 
Response after Non-Final Action



Event publication date=2015-02-22 
Event code=US/CTFR 
Event type=Examination events 
Event type=OA 
Event type=OAO 
Final Rejection



Event publication date=2015-06-18 
Event code=US/NOAPLF 
Event type=APL 
Notice of Appeal Filed



Event publication date=2015-06-18 
Event code=US/136G 
Event type=OAO 
Request for Extension of Time - Granted



Event publication date=2015-11-09 
Event code=US/TRK1OFF 
Event type=ACL 
Event type=Examination events 
TrackOne Accelerated OFF



Event publication date=2015-11-09 
Event code=US/APB 
Event type=APL 
Event type=OAI 
Appeal Brief Filed



Event publication date=2015-11-09 
Event code=US/136G 
Event type=OAO 
Request for Extension of Time - Granted



Event publication date=2015-11-12 
Event code=US/APLRVC 
Event type=APL 
Appeal Brief Review Complete



Event publication date=2016-02-05 
Event code=US/IDS 
Event type=Examination events 
Event type=OAI 
Information Disclosure Statement Filed



Event publication date=2016-04-07 
Event code=US/EXET 
Event type=Examination events 
Event type=OAO 
Event type=INT 
Interview Summary - Examiner Initiated - telephonic



Event publication date=2016-04-18 
Event code=US/EXAC 
Event type=Examination events 
Event type=OAO 
Examiner's Amendment Communication



Event publication date=2016-04-21 
Event code=US/NOAM 
Event indicator=Pos 
Event type=Examination events 
Event type=OAO 
Mail Notice of Allowance



Event publication date=2016-05-06 
Event code=US/AS 
Event type=Change of name or address 
Event type=Reassignment 
Assignment
Owner: AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC., GEORG

Effective date of the event=2015-12-29 
CHANGE OF NAME ASSIGNOR:GEORGIA REGENTS RESEARCH INSTITUTE, INC. REEL/FRAME:038637/0950 



Event publication date=2016-05-06 
Event code=US/AS 
Event type=Change of name or address 
Event type=Reassignment 
Assignment
Owner: GEORGIA REGENTS RESEARCH INSTITUTE, INC., GEORGIA

Effective date of the event=2013-06-10 
CHANGE OF NAME ASSIGNOR:GEORGIA HEALTH SCIENCES UNIVERSITY RESEARCH INSTITUTE, INC. REEL/FRAME:038637/0987 



Event publication date=2016-05-11 
Event code=US/ANA 
Event type=Corrections 
Event type=OAI 
Amendment after Notice of Allowance (Rule 312)



Event publication date=2016-06-02 
Event code=US/N271 
Event type=Examination events 
Event type=OAO 
Response to Amendment under Rule 312



Event publication date=2016-06-03 
Event code=US/RLRCPTC 
Event type=Administrative notifications 
Event type=OAO 
Filing Receipt - Corrected



Event publication date=2016-06-17 
Event code=US/POAC 
Event type=Change of name or address 
Change in Power of Attorney (May Include Associate POA)



Event publication date=2016-07-11 
Event code=US/APRDY 
Event indicator=Pos 
Event type=Examination events 
Application Is Considered Ready for Issue



Event publication date=2016-08-31 
Event code=US/PAT 
Event indicator=Pos 
Event type=Event indicating In Force 
Patented Case



Event publication date=2016-08-31 
Event code=US/ISSM 
Event indicator=Pos 
Event type=Examination events 
Event type=OAO 
Event type=Restitution or restoration 
Issue Notification Mailed



Event publication date=2016-09-20 
Event code=US/B2 
Event indicator=Pos 
Event type=Event indicating In Force 
Granted patent as second publication

Publication country=US 
Publication number=US9446017 
Publication stage Code=B2 
Publication date=2016-09-20 
Standardized publication number=US9446017 



Event publication date=2016-09-20 
Event code=US/354 
Event indicator=Pos 
Event type=Extension of term of duration of protection 
Patent term extended under  35 U.S.C 154(b) until/for
Delays (A,B,C): 0  Overlap Delays: 0  Non Overlap Delays: 144  
PTO Office Delays: 0  Applicant Delays: 315  Adjustment total: 
Number of days of extension=0



Event publication date=2017-01-12 
Event code=US/POAC 
Event type=Change of name or address 
Change in Power of Attorney (May Include Associate POA)
专利类型码
A1 B2
国别省市代码
若您需要申请原文,请登录。

最新评论

暂无评论。

登录后可以发表评论


意见反馈
返回顶部