Phmg modified antimicrobial agents 机翻标题: 暂无翻译,请尝试点击翻译按钮。

公开号/公开日
WO2013005215 A2 2013-01-10 [WO201305215]WO2013005215 A3 2013-03-28 [WO201305215] / 2013-01-102013-03-28
申请号/申请日
2012WO-IL50237 / 2012-07-05
发明人
DOMB ABRAHAM J;RATNER STANISLAV;MIZRAHI OREN;WILDER HAIM;FRENKEL HELLA;
申请人
STRAUSS WATER;
主分类号
IPC分类号
A01N-047/44A01P-001/00
摘要
(WO201305215) The invention concerns an antimicrobial agent comprising modified polyhexamethylene guanidine (PHMG), products containing it and uses thereof.
机翻摘要
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地址
代理人
代理机构
;
优先权号
2011US-61504447 2011-07-05
主权利要求
(WO201305215) CLAIMS: 1. An antimicrobial agent comprising modified polyhexamethylene guanidine (PHMG), said modified PHMG being selected from a cross-linked PHMG, a complexed PHMG, a grafted PHMG, a surface-associated PHMG, an N-halogenated PHMG, a mixture of PHMG and polyethylene glycol (PEG), and combinations thereof. 2. The antimicrobial agent of claim 1, wherein said modified PHMG has a molecular weight of between about 1 ,000 and 20,000 g/mole. 3. The antimicrobial agent of claim 2, wherein said modified PHMG has a molecular weight of between about 2,000 and 5,000 g/mole. 4. The antimicrobial agent of any one of claims 1 to 3, wherein said modified PHMG is substantially water insoluble. 5. The antimicrobial agent of claim 1, wherein said modified PHMG being a cross- linked PHMG comprising PHMG and a cross-linking agent. 6. The antimicrobial agent of claim 1, wherein the cross-linked PHMG is at least 0.1% cross-linked. 7. The antimicrobial agent of claim 1 , wherein the cross-linked PHMG is between 1 % and 30% cross-linked. 8. The antimicrobial agent of any one of claims 5 to 7, wherein the molar ratio between said PHMG and said cross-linking agent is between 99.9: 0.1 to 70:30. 9. The antimicrobial agent of any one of claims 5 to 8, wherein said cross-linking agent is selected from a triamine, a polyetheramine (Jeffamine), poly(vinyl amine), polyallylamine, a diisocyanate or polyisocyanate, a di or polyacyl halide, a dialdehyde or polyaldehyde, a diepoxide or polyepoxide, and poly(aminomethyl methacrylate). 10. The antimicrobial agent of claim 9, wherein said cross-linking agent is a triamine. 11. The antimicrobial agent of claim 9, wherein said cross-linking agent is a polyetheramine. 12. The antimicrobial agent of claim 9, wherein said cross-linking agent is a polyallylamine. 13. The antimicrobial agent of claim 9, wherein said cross-linking agent is a diisocyanate or polyisocyanate being selected from phenylene di and tri-isocyanates, triphenylmethane trisocyanate and hexamethylene diisocyanate. 14. The antimicrobial agent of claim 9, wherein said cross-linking agent is an acyl- halide being selected from citroyl chloride, phenylene tricarboxyloyl chloride and poly(acryloyl chloride). 15. The antimicrobial agent of claim 9, wherein said cross-linking agent is a di or polyaldehydes being selected from glutar aldehyde, polyaldehydes based on oxidized oligo and polysaccharides. 16. The antimicrobial agent of claim 9, wherein said cross-linking agent is diepoxide selected from 1,3-butadienediepoxide and 4-vinylcycl-l-cohexene diepoxide. 17. The antimicrobial agent of claim 1, wherein said modified PHMG is a complexed PHMG comprising PHMG and a complexing agent. 18. The antimicrobial agent of claim 17, wherein said complexing agent is at least one polyanion. 19. The antimicrobial agent of claim 18, wherein the molar ratio between said PHMG and said polyanion is between about 10:90 to 90: 10. 20. The antimicrobial agent of claim 17 or 18, wherein said polyanion is selected from an from an acrylic acid polymer, a sulfate containing polymer, alginate, a polymer comprising hyaluronic acid moieties, homopolymers or copolymers of methacylic or acrylic acid, and carboxy methyl cellulose. 21. The antimicrobial agent of claim 1, wherein said modified PHMG is a grafted PHMG, having side chain moieties grafted onto the PHMG backbone. 22. The antimicrobial agent of claim 21, wherein said side chain moieties are selected from primary amines, aldehydes, isocyanates and guanidine groups. 23. The antimicrobial agent of claim 21 or 22, wherein the distance between two adjacent side chains is between 1 and 9 monomers/PHMG carbons. 24. The antimicrobial agent of any one of claims 21 to 23, wherein the side chain moieties have a molecular weight of between 300 to 3,000 g/mole. 25. The antimicrobial agent of claim 1, wherein said modified PHMG is a surface- associated PHMG, the PHMG being associated to at least a portion of an external surface of a particle. 26. The antimicrobial agent of claim 25, wherein said association is substantially not labile. 27. The antimicrobial agent of claim 26, wherein said association is selected from ionic association, hydrophobic association, amphiphilic association, covalent association, hydrogen bonding and combinations thereof. 28. The antimicrobial agent of any one of claims 25 to 27, wherein said portion is at least 10% of the external surface of the particle. 29. The antimicrobial agent of claim 28, wherein said particle is substantially coated with said PHMG. 30. The antimicrobial agent of any one of claims 25 to 29, wherein said particle is selected from a substantially spherical particle, a flake, a pellet, a substantially cylindrical particle, and a fiber. 31. The antimicrobial agent of any one of claims 25 to 30, wherein said particle has an average size of between 100 and 10,000 nm. 32. The antimicrobial agent of any one of claims 25 to 31, wherein said particle is selected from a silica particle, a polystyrene particle, and a particle having amine groups on its external surface. 33. The antimicrobial agent of claim 1, wherein said modified PHMG is an N- halogenated PHMG. 34. The antimicrobial agent of claim 33, wherein said N-halogenated PHMG is between 5 to 60% halogenated. 35. The antimicrobial agent of claim 33 or 34, wherein said N-halogenated PHMG is halogenated with bromine or chlorine. 36. The antimicrobial agent of claim 35, wherein upon contact with water, active bromine or active chlorine is released from said N-halogenated PHMG. 37. The antimicrobial agent of claim 1, wherein said modified PHMG is a mixture of PHMG and polyethylene glycol (PEG). 38. The antimicrobial agent of claim 37, wherein said PEG has a molecular weight of between 10,000 and 50,000 g/mole. 39. The antimicrobial agent of claim 38, wherein said PEG has a molecular weight of between 20,000 and 40,000 g/mole. 40. The antimicrobial agent of any one of claims 37 to 39, wherein the weight ratio between PHMG and PEG is between 1 :99 and 30:70. 41. The antimicrobial agent of claim 40, wherein the weight ratio between PHMG and PEG is between 5:95 and 25:75. 42. A self-sterilizing product comprising the antimicrobial agent of any one of claims 1 to 41. 43. The self-sterilizing product of claim 42, being selected from a water filtering medium, a water filter, a water purifier, a water container, and a water conduction tube. 44. Use of the antimicrobial agent of any one of claims 1 to 41 in the manufacturing of a product having a self-sterilizing surface. 45. A method for reducing bacterial concentration in water, the method comprising contacting the water with the antimicrobial agent of any one of claims 1 to 41. 46. A method for preventing growth of bacteria on a surface being in contact with water for at least a period of time, the method comprising incorporating the antimicrobial agent of any one of claims 1 to 41 onto said surface. 47. The method of claim 46, wherein said surface is coated with the antimicrobial agent of any one of claims 1 to 41. 48. The method of claim 47, wherein said surface consists of the antimicrobial agent of any one of claims 1 to 41. 49. A coating disposed on a substrate surface, the coating comprising an antimicrobial agent according to any one of claims 1 to 41. 50. The coating according to claim 49, wherein the substrate is designed for water applications. 51. The coating according to claim 49, wherein the substrate to be coated is designed for biological uses or devices used in medical applications. 52. The coating according to claim 49, wherein the substrate being any region of a storage container or a delivery system for use in food packaging, food and beverage containers, food and beverage preparation or disposing equipment. 53. The coating according to claim 49, wherein the substrate is of a product selected from a filtration device, a water line, a reusable water container, a hydration system, a water bottle and a container. 54. A product implementing an antimicrobial agent according to any one of claims 1 to 42, the product being selected from personal products and industrial products. 55. The product according to claim 54, being selected from products for sporting activities, orthodontic devices, face or breathing masks, pacifiers, contact lenses, food preparation surfaces, food packaging, reusable water containers, hydration systems, water bottles, computer keyboards, telephones, rental car steering wheels, health club equipment, whirlpool spas and humidifiers. 56. The product according to claim 55, being selected from filtration devices and water lines, reusable water containers, hydration systems, water bottles and containers.
法律状态
(WO201305215) LEGAL DETAILS FOR WO2013005215  Actual or expected expiration date=2015-01-05    Legal state=DEAD    Status=LAPSED     Event publication date=2012-07-05  Event code=WO/APP  Event indicator=Pos  Event type=Examination events  Application details  Application country=WO WOIL2012050237  Application date=2012-07-05  Standardized application number=2012WO-IL50237     Event publication date=2013-01-10  Event code=WO/A2  Event type=Examination events  International application published with declaration under Article 17 (2) (a)  Publication country=WO  Publication number=WO2013005215  Publication stage Code=A2  Publication date=2013-01-10  Standardized publication number=WO201305215     Event publication date=2013-03-28  Event code=WO/A3  Event indicator=Pos  Event type=Examination events  Later publication of ISR with revised front page  Publication country=WO  Publication number=WO2013005215  Publication stage Code=A3  Publication date=2013-03-28  Standardized publication number=WO201305215     Event publication date=2015-01-05  Event code=WO/EETL  Event type=Event indicating Not In Force  PCT Application validity period expired. LEGAL DETAILS FOR DESIGNATED STATE DE  Actual or expected expiration date=2014-01-07    Legal state=DEAD    Status=LAPSED   Corresponding cc:  Designated or member state=DE     Event publication date=2014-01-07  Event code=WO/NENP  Event type=Event indicating Not In Force  Non-entry into the national phase in: Corresponding cc:  Designated or member state=DE
专利类型码
A2A3
国别省市代码
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