(EP3237375) Crystals of alanine n-acetic acid precursors, process to prepare them and their use 机翻标题: 暂无翻译,请尝试点击翻译按钮。

源语言标题
(EP3237375) Crystals of alanine n-acetic acid precursors, process to prepare them and their use
公开号/公开日
EP3237375EP3237375 / 2017-11-012019-04-10
申请号/申请日
EP15820137 / 2015-12-21
发明人
BOUWMAN ALBERTUS JACOBUS MARIAJONGEN HUBERTUS JOHANNESDOPPEN ROY GÉRARDHEUS MARTINSCHOMAKER ELWIN;
申请人
AKZO NOBEL;
主分类号
IPC分类号
C07C-237/06 C07C-255/25
摘要
(EP3237375) The present invention relates to alanine N-acetic acid precursors of formula (i) COOM-CH(CH3)-NH-(CH2CN), wherein M is hydrogen (alanine N-monoacetonitrile), or (ii) COOM-CH(CH3)-N-(CH2CN)2, wherein 0 to 50% of all M is sodium or potassium and 50 to 100% of all M is hydrogen (alanine Ν,Ν-diacetonitrile and its partial sodium or potassium salts) comprising L-alanine to D-alanine in a range of from 75:25 to 50:50 (L:D), or (iii) COOM-CH(CH3)-N-(CH2CONH2)2, wherein M is hydrogen (alanine Ν,Ν-diacetamide), in the form of crystals, and relates to a process to prepare these precursors and their use, especially to give MGMA or MGDA.
机翻摘要
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地址
代理人
(EP3237375) Akzo Nobel Chemicals IP Group ([NL]) Reg. Nb: 101721562
代理机构
;
优先权号
2014EP-0200045 2015WO-EP80837
主权利要求
(EP3237375) 1. Alanine N-acetic acid precursors of formula COOM-CH(CH3)-NH-(CH2CN), wherein M is hydrogen (alanine N-monoacetonitrile), or COOM-CH(CH3)-N-(CH2CN)2, wherein 0 to 50% of all M is sodium or potassium and 50 to 100% of all M is hydrogen (alanine N,N-diacetonitrile and its partial sodium or potassium salts) comprising L-alanine to D-alanine in a range of from 75:25 to 50:50 (L:D), or COOM-CH(CH3)-N-(CH2CONH2)2, wherein M is hydrogen (alanine N,N-diacetamide), and wherein the precursors are in the form of crystals. 2. Alanine N monoacetonitrile or alanine N,N-diacetamide precursors of claim 1 comprising L-alanine to D-alanine in a range of from 75:25 to 50:50 (L:D). 3. Process to prepare the precursors according to claim 1 or 2, comprising:   - a first step providing an aqueous solution of the alanine N-acetic acid precursor;   - optionally for the alanine N monoacetonitrile or alanine N,N diacetamide precursor, a second step ensuring the alanine is at least partly racemized, one step after the other in random order or simultaneously, and   - a third step allowing the aqueous solution to crystallize. 4. Process of claim 3, wherein in the first step the alanine N-acetic acid precursor is made by reacting alanine or partially neutralized alanine with 0.8-2.4 molar equivalents of formaldehyde and 0.8-2.4 molar equivalents of hydrogen cyanide, wherein the reaction takes place by simultaneous dosing of both the formaldehyde and the hydrogen cyanide, or by dosing at least 40% of the amount of formaldehyde before dosing of the hydrogen cyanide is started. 5. Process according to claim 3 or 4, wherein the second step includes a concentrating step that is carried out until the solution has a concentration of equal to or more than 15 wt% to up to or equal to 80 wt% of the precursor, based on the weight of the aqueous solution. 6. Process according to any one of claims 3 to 5, wherein the third step comprises crystallization by allowing the solution to stand for an extended period of time and/or cooling and/or seeding. 7. Process according to any one of claims 3 to 6, wherein the third step comprises crystallization by spraying the aqueous solution of the second step on seeding crystals. 8. Process according to any one of claims 3 to 7, wherein the third step is performed at a temperature of below 40°C. 9. Process according to any one of claims 3 to 8, wherein the process is a continuous process. 10. Use of the precursors according to claim 1 or 2 in preparing MGMA or MGDA, as a crystallization inhibitor, in detergents, agriculture, in oil field applications, feedstock applications, pharmaceutical applications, and in water treatment. 11. Process to hydrolyze the precursors of claim 1 or 2 to give MGMA or MGDA containing the steps of adding together the precursors and an alkali metal salt in an aqueous solution and heating this solution to a temperature of at least 80°C, preferably boiling point.
法律状态
GRANTED
专利类型码
A1B1
国别省市代码
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