(US20190054213) Antimicrobial Medical Devices 机翻标题: 暂无翻译,请尝试点击翻译按钮。

源语言标题
(US20190054213) Antimicrobial Medical Devices
公开号/公开日
US20190054213 / 2019-02-21
申请号/申请日
US16/104,442 / 2018-08-17
发明人
HERMEL-DAVIDOCK THERESA DATASHVILI TEA
申请人
BECTON DICKINSON & COMPANY
主分类号
IPC分类号
A01N-025/10 A01N-043/40 A01N-043/90 A01N-059/16 A01N-059/20 A61K-031/44 A61K-031/4745 A61K-033/34 A61K-033/38 A61K-047/32 A61L-029/04 A61L-029/16
摘要
(US20190054213)
Medical devices comprise a polymeric body comprising: a base polymeric formulation comprising at least a polymer or co-polymer of propylene; and an additive comprising a copolymer having a polypropylene backbone and hybrid micromolecule side-chains based on organo-functional silanes (PP-g-XSiOA) in the presence of a co-agent, for example, difunctional metallic diacrylate monomers, where “X” is an organic group or an organo-functional group, and “A” is a metal, an inorganic oxide, an inorganic hydroxide, or any other inorganic material. X may be derived from a compound selected from the group consisting of epoxy, amino, acrylate, methacryloxy, and vinyl; and A is selected from the group consisting of: silicon, (Si), aluminum (Al), iron (Fe), titanium (Ti), silver (Ag), zinc (Zn), nickel (Ni), calcium (Ca), copper (Cu), tin (Sn); oxides thereof; hydroxides thereof; and mixtures of the foregoing. Antimicrobial agents are included in the polymeric body. The medical devices have enhanced antimicrobial properties.
机翻摘要
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地址
代理人
代理机构
优先权号
2017US-62547167 2018US-16104442 2018US-62684946 2018US-62715868
主权利要求
(US20190054213)
What is claimed is:
1. A medical device comprising: 
 a polymeric body comprising: 
  a base polymeric formulation comprising at least a polymer or co-polymer of propylene; and 
  an additive comprising a copolymer having a polypropylene backbone and hybrid micromolecule side-chains based on organo-functional silanes (PP-g-XSiOA), where “X” is an organic group or an organo-functional group; and “A” is a metal, an inorganic oxide, an inorganic hydroxide, or any other inorganic material; 
  the PP-g-XSiOA being in a blend with the base polymeric formulation in an amount in the range of about 0.01 to about 20.0% by weight of the blend; and 
 an antimicrobial agent.
2. The medical device of claim 1, wherein the antimicrobial agent comprises: berberine chloride, berberine chloride hydrate, octinedine dihydrochloride, 4-chlorophenyl methyl sulfone, climbazole, piroctone olamine, silver sulfadiazine, copper particles, silver particles, or combinations thereof.
3. The medical device of claim 2, wherein the antimicrobial agent is present in an amount in the range of 0.02 to 3% by weight of the blend of additive and base polymeric formulation.
4. The medical device of claim 1, wherein the PP-g-XSiOA is according to Formula (I):
wherein X is an organic group or an organo-functional group; A is a metal, an inorganic oxide, an inorganic hydroxide, or any other inorganic material; and “n” is in the range of about 78 to 99.9 mole percent; m is in the range of about 0.1 to 20 mole percent; the molar value of “y” is in the range of about 0 to 2.0 mole percent; and “Z”, when y is greater than 0, comprises: M-X2; XSiOR; or XSiOH, wherein “M-X2” is an organo-metal salt and “OR” is an alkoxy group having 1 to 4 carbons.
5. The medical device of claim 1, wherein the base polymeric formulation comprises polypropylene, a polyethylene-polypropylene co-polymer, a polypropylene-containing thermoplastic elastomer (TPE), or combinations thereof.
6. The medical device of claim 1, wherein X of the PP-g-XSiOA is derived from a compound selected from the group consisting of epoxy, amino, acrylate, methacryloxy, and vinyl; and A is selected from the group consisting of: silicon, (Si), aluminum (Al), iron (Fe), titanium (Ti), silver (Ag), zinc (Zn), nickel (Ni), calcium (Ca), copper (Cu), tin (Sn); oxides thereof; hydroxides thereof; and mixtures of the foregoing.
7. The medical device of claim 1, wherein the PP-g-XSiOA has a melting point in the range of 140 to 180° C.
8. The medical device of claim 1, wherein the PP-g-XSiOA has a capillary viscosity in the range of 100 to 300 Pa·s at 180 s−1.
9. The medical device of claim 1, wherein the PP-g-XSiOA has a weight average molecular weight (Mw) in the range of about 100,000 to about 350,000 g/mol.
10. The medical device of claim 1, wherein the PP-g-XSiOA has a dispersity index in the range of 1.5 to 9.
11. The medical device of claim 1, wherein the PP-g-XSiOA has a long chain branching frequency in the range of 0.007 to 0.017 per 1000 carbon.
12. The medical device of claim 1, wherein the PP-g-XSiOA has a melt flow rate in the range of 15 to 55 g/10 minutes.
13. The medical device of claim 1 in the form of tubing, barrel, rod, or any other geometric shape.
14. A method of making a medical device comprising: 
 obtaining a copolymer having a polypropylene backbone and hybrid micromolecule side-chains based on organo-functional silanes (PP-g-XSiOA), where “X” is an organic group or an organo-functional group; and “A” is a metal, an inorganic oxide, an inorganic hydroxide, or any other inorganic material; 
 combining the PP-g-XSiOA with a base polymeric formulation comprising at least a polymer or co-polymer of propylene to form a blend, the PP-g-XSiOA being present in the blend in an amount in the range of about 0.01 to about 20.0% by weight of the blend; 
 adding an antimicrobial agent to the blend to form a mixture; and 
 forming a polymeric body from the mixture.
15. The method of claim 14, wherein the antimicrobial agent comprises: berberine chloride, berberine chloride hydrate, octinedine dihydrochloride, 4-chlorophenyl methyl sulfone, climbazole, piroctone olamine, silver sulfadiazine, copper particles, silver particles, or combinations thereof.
16. The method of claim 14, wherein the base polymeric formulation comprises polypropylene, a polyethylene-polypropylene co-polymer, a polypropylene-containing thermoplastic elastomer (TPE), or combinations thereof.
17. The method of claim 14, wherein the PP-g-XSiOA is according to Formula (I):
wherein X is an organic group or an organo-functional group; A is a metal, an inorganic oxide, an inorganic hydroxide, or any other inorganic material; and “n” is in the range of about 78 to 99.9 mole percent; m is in the range of about 0.1 to 20 mole percent; the molar value of “y” is in the range of about 0 to 2.0 mole percent; and “Z”, when y is greater than 0, comprises: M-X2; XSiOR; or XSiOH, wherein “M-X2” is an organo-metal salt and “OR” is an alkoxy group having 1 to 4 carbons.
18. The method of claim 17, wherein X of the PP-g-XSiOA is derived from a compound selected from the group consisting of epoxy, amino, acrylate, methacryloxy, and vinyl; and A is selected from the group consisting of: silicon, (Si), aluminum (Al), iron (Fe), titanium (Ti), silver (Ag), zinc (Zn), nickel (Ni), calcium (Ca), copper (Cu), tin (Sn); oxides thereof; hydroxides thereof; and mixtures of the foregoing.
19. The method of claim 14, wherein the medical device is in the form of tubing, barrel, rod, or any other geometric shape.
法律状态
PENDING
专利类型码
A1
国别省市代码
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