Mechanical and<i> In Vitro</i> Antibacterial Properties of a Porous Ti–6Al–4V Scaffold Combined with Vancomycin-Loaded Polymethyl Methacrylate by Three-Dimensional Printing 机翻标题: 暂无翻译,请尝试点击翻译按钮。

来源
Journal of biomaterials and tissue engineering
年/卷/期
2018 / 8 / 5
页码
740-749
ISSN号
2157-9083
作者
Yao, Qing-Qiang;Sui, Ji-Sheng;Li, Jia-Yi;Xu, Yan;Wu, Xiao-Ling;Liu, Nancy Q.;Buser, Zorica;Wang, Li-Ming;Zhou, Jin;Jiang, Chun-Zhi;
摘要
The study aims to investigate the construction and efficacy of a 3D-printed antibiotic scaffold through the combination of vancomycin-loaded polymethyl methacrylate with a 3D-printed porous titanium scaffold. The titanium scaffolds were constructed with orthogonal micro-structures usingselective laser melting and the micro-pores were filled with vancomycin-loaded polymethyl methacrylate while the polymethyl methacrylate was in its liquid phase. Structural features, the release of antibiotics, and the antibacterial performance of vancomycin-loaded polymethyl methacrylate-titaniumscaffolds were measured and compared with a titanium-free control group. Tests were also conducted to determine the loading force, deformation, and maximum pressure that the three different scaffolds could withstand. The results demonstrate that vancomycin-loaded polymethyl methacrylate maypermeate into the pores of a 3D-printed titanium scaffold, which allows the vancomycin-loaded polymethyl methacrylate-titanium scaffold to remain active over a longer period and have a stronger effect on<i> Staphylococcus aureus populations than a vancomycin-loaded polymethyl methacrylateblock (<i>P < 0.05). The vancomycin-loaded polymethyl methacrylate-titanium scaffold also has greater biomechanical strength than its constituents. These results suggest that selective laser meltingis a promising technique for producing porous 3D-printedtitanium scaffolds and that maybe efficient and reliable in the treatment of bone infection when impregnated with vancomycin-loaded polymethyl methacrylate.
机翻摘要
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关键词/主题词
ANTIBACTERIAL SCAFFOLD;THREE-DIMENSIONAL PRINTING;TI–6AL–4V POROUS SCAFFOLD;VANCOMYCIN-LOADED PMMA;
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