Antibodies against immunogenic glycopeptides, compositions comprising the same and use thereof 机翻标题: 暂无翻译,请尝试点击翻译按钮。

公开号/公开日
US2017107297 A1 2017-04-20 [US20170107297] / 2017-04-20
申请号/申请日
2015US-15126945 / 2015-03-19
发明人
CHANG CHIH-LONG;WU CHAO-CHIH;
申请人
MACKAY MEDICAL FOUNDATION THE PRESBYTERIAN CHURCH TAIWAN MACKAY MEMORIAL HOSPITAL;MACKAY MEMORIAL HOSPITAL OF TAIWAN PRESBYTERIAN CHURCH & MACKAY MEMORIAL SOCIAL WORK FOUNDATION;
主分类号
IPC分类号
A61K-039/395A61K-045/06C07K-016/30
摘要
(US20170107297) Disclosed herein are antibodies which specifically bind to at least one epitope defined by the immunogenic glycopeptide.  Other aspects of the present disclosure are pharmaceutical composition comprising the antibody; and method for preventing and/or treating Globo-H-positive cancer.
机翻摘要
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地址
代理人
代理机构
;
优先权号
2014US-61955216 2014-03-19 2015US-15126945 2015-03-19 2015WO-US21413 2015-03-19
主权利要求
(US20170107297) 27. An anti-Globo H antibody or antigen-binding portion thereof comprising: (a) H-CDR1 comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 1, 2, 3, 4, and a variant of at least 90% identity to any one of SEQ ID NOs: 1-4; (b) H-CDR2 comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 5, 6, and a variant of at least 90% identity to any one of SEQ ID NOs: 5-6; (c) H-CDR3 comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 7, 8, 9, and a variant of at least 90% identity to any one of SEQ ID NOs: 7-9; (d) L-CDR1 comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 10, 11, 12, 13 and a variant of at least 90% identity to any one of SEQ ID NOs: 10-13; (e) L-CDR2 comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 14, 15, 16, and a variant of at least 90% identity to any one of SEQ ID NOs: 14-16; and (f) L-CDR3 comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 17, 18, 19, and a variant of at least 90% identity to any one of SEQ ID NOs: 17-19.
法律状态
(US20170107297) LEGAL DETAILS FOR US2017107297  Actual or expected expiration date=2035-03-19    Legal state=ALIVE    Status=PENDING     Event publication date=2015-03-19  Event code=US/APP  Event indicator=Pos  Event type=Examination events  Application details  Application country=US US15126945  Application date=2015-03-19  Standardized application number=2015US-15126945     Event publication date=2015-03-19  Event code=US/EXMR  Event type=Administrative notifications  USPTO Examiner Name Primary Examiner: NATARAJAN, MEERA    Event publication date=2015-03-19  Event code=US/ART  Event type=Administrative notifications  USPTO Art Group  ART=1643     Event publication date=2015-03-19  Event code=US/DK  Event type=Examination events  Attorney Docket Number Docket Nbr: 08532.001US1 Customer Nbr: 39564    Event publication date=2015-03-19  Event code=US/ENT  Event type=Administrative notifications  Business Entity Status: SMALL    Event publication date=2015-03-19  Event code=US/AIA  Event type=Administrative notifications  First Inventor File Indicated:  AIA=Yes     Event publication date=2016-09-16  Event code=US/SPLREQ  Event type=ACL  Cancer Immunotherapy Request    Event publication date=2016-09-16  Event code=US/ENTYSTA  Event type=Administrative notifications  Entity Status Set to Undiscounted    Event publication date=2016-12-14  Event code=US/SMALL  Event type=Administrative notifications  Appl Has Filed a Verified Statement of Micro to Small Entity Status    Event publication date=2016-12-15  Event code=US/AS  Event type=Change of name or address  Event type=Reassignment  Assignment Owner: MACKAY MEMORIAL HOSPITAL OF TAIWAN PRESBYTERIAN CH  Effective date of the event=2015-07-31  ASSIGNMENT OF ASSIGNORS INTEREST ASSIGNORS:CHANG, CHIH-LONG WU, CHAO-CHIH REEL/FRAME:040637/0916     Event publication date=2016-12-15  Event code=US/AS  Event type=Change of name or address  Event type=Reassignment  Assignment Owner: DCB-USA, LLC, DELAWARE  Effective date of the event=2015-09-22  ASSIGNMENT OF ASSIGNORS INTEREST ASSIGNOR:MACKAY MEMORIAL HOSPITAL OF TAIWAN PRESBYTERIAN CHURCH AND MACKAY MEMORIAL SOCIAL WORK FOUNDATION REEL/FRAME:040638/0005     Event publication date=2016-12-15  Event code=US/AS  Event type=Change of name or address  Event type=Reassignment  Assignment Owner: MACKAY MEMORIAL HOSPITAL OF TAIWAN PRESBYTERIAN CH  Effective date of the event=2015-09-22  ASSIGNMENT OF ASSIGNORS INTEREST ASSIGNOR:MACKAY MEMORIAL HOSPITAL OF TAIWAN PRESBYTERIAN CHURCH AND MACKAY MEMORIAL SOCIAL WORK FOUNDATION REEL/FRAME:040638/0005     Event publication date=2016-12-15  Event code=US/AS  Event type=Change of name or address  Event type=Reassignment  Assignment Owner: MACKAY MEDICAL FOUNDATION THE PRESBYTERIAN CHURCH ASSIGNMENT OF ASSIGNORS INTEREST ASSIGNORS:DCB-USA, LLC MACKAY MEDICAL FOUNDATION THE PRESBYTERIAN CHURCH IN TAIWAN MACKAY MEMORIAL HOSPITAL SIGNING DATES FROM 20160805 TO 20160810 REEL/FRAME:040638/0289     Event publication date=2016-12-28  Event code=US/IDS  Event type=Examination events  Event type=OAI  Information Disclosure Statement Filed    Event publication date=2017-01-11  Event code=US/APPFILEREC  Event type=Administrative notifications  Event type=OAO  Filing Receipt    Event publication date=2017-02-08  Event code=US/PTARDY  Event indicator=Pos  Event type=Examination events  Patent Term Adjustment - Ready for Examination    Event publication date=2017-03-16  Event code=US/DOCK  Event indicator=Pos  Event type=Examination events  Case Docketed to Examiner in GAU    Event publication date=2017-03-17  Event code=US/M903  Event indicator=Pos  Event type=Examination events  Event type=OAO  Notice of DO/EO Acceptance Mailed    Event publication date=2017-03-17  Event code=US/RECEIPTUP  Event type=Administrative notifications  Event type=OAO  Filing Receipt - Updated    Event publication date=2017-03-21  Event code=US/TR1RQG  Event type=ACL  Event type=Examination events  TrackOne Accelerated Request Granted    Event publication date=2017-03-21  Event code=US/SPLREQG  Event type=ACL  Cancer Immunotherapy Request Granted    Event publication date=2017-04-16  Event code=US/CTNF  Event type=Examination events  Event type=OA  Event type=OAO  Non-Final Rejection    Event publication date=2017-04-20  Event code=US/A1  Event type=Examination events  Application published  Publication country=US  Publication number=US2017107297  Publication stage Code=A1  Publication date=2017-04-20  Standardized publication number=US20170107297     Event publication date=2017-04-20  Event code=US/PGPUBN  Event indicator=Pos  Event type=Examination events  Event type=OAO  PG-Pub Issue Notification    Event publication date=2017-07-24  Event code=US/EXAC  Event type=Examination events  Event type=OAO  Examiner's Amendment Communication    Event publication date=2017-08-02  Event code=US/NOAM  Event indicator=Pos  Event type=Examination events  Event type=OAO  Mail Notice of Allowance
专利类型码
A1
国别省市代码
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