Bioactive glass compositions, methods for their preparation, and a manufacturing method thereof, as well as glass raw material 机翻标题: 暂无翻译,请尝试点击翻译按钮。

源语言标题
(JP2014512325) 生理​活性​ガラス​組成​物、その​調製​方法、及び​その​製造​方法、並びに​ガラス​原料
公开号/公开日
JP2014512325 A 2014-05-22 [JP2014512325] / 2014-05-22
申请号/申请日
2014JP-0503262 / 2012-04-05
发明人
;
申请人
REG4LIFE REGENERATION TECHNOLOGY;
主分类号
IPC分类号
A01N-025/08A01N-059/16A01P-003/00A61K-006/06A61K-008/19A61L-027/00A61Q-011/00C03C-003/062C03C-003/078C03C-003/097C03C-003/112C03C-012/00
摘要
(JP2014512325) The present invention relates to development of set of bioactive glasses and glass-ceramics compositions that are able to promote a fast deposition layer of carbonated hydroxyapatite upon immersion in simulated body fluid (SBF) for time periods as short as one hour.  Such compositions might include fluorides, and a variety of oxides (or their precursor compounds), such as Na 2 O-Ag 2 O-SrO-CaO-MgO-ZnO-P 2 O 5 -SiO 2 -Bi 2 O 3 -B 2 O 3 -CaF 2 , be prepared by the melt route or by the sol-gel process, with the specific compositions and the preparation route selected according to the intended functionalities, which can present controlled biodegradation rates and bactericidal activity.  The powders derived from glass melts purred in cold water (frits) may completely densify by sintering at temperatures up to 800°C without devitrification, resulting in bioglass compacts with high flexural strength (ˆ¼85 MPa).  The bioactive glass powders prepared by sol-gel densify at lower temperatures due to their higher specific surface area and reactivity.  (From EP2695623 A1)
机翻摘要
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地址
代理人
代理机构
;
优先权号
2011PT-0105617 2011-04-05 2012WO-IB51681 2012-04-05
主权利要求
(JP2014512325) 1. Calcium oxide 20-60% molar; 0-30 moles % of magnesium oxide; O.lg 0-10% phosphorous pentoxide; O.lg 29-60% silicon dioxide; formula CaF2 O.lg 0-5% calcium fluoride; composition comprises bioactive glass.  2. Bioactive glass composition according to claim 1 of, less than 5 molar % of an alkali metal concentration further comprises a bioactive glass composition and.  3. Claims 1 or 2 composition of bioactive glass, characterized in that the alkali-free glass composition and a bioactive.  4. Wherein any one of claims 1-3 bioactive glass composition, wherein the silicon dioxide and phosphorous pentoxide glass Network former and characterized in that the bioactive glass composition.  5. Wherein one of the preceding claims claims 1-4 bioactive glass composition comprising, in mole % of calcium oxide 25-53; 2-24 moles % of magnesium oxide; O.lg 1.7-8% phosphorous pentoxide; O.lg 29-50% silicon dioxide; formula CaF2 O.lg 0-3% calcium fluoride; characterized in that the bioactive glass comprises the composition.  6. Claims 1-5 of any one of the bioactive glass composition, the source of calcium, calcium oxide, calcium hydroxide, calcium carbonate, calcium nitrate, calcium sulfate, calcium silicate and is selected from at least one of a bioactive glass composition and.  7. Claims 1-6 of any one of the bioactive glass composition, the magnesium source, a magnesium oxide, magnesium hydroxide, magnesium carbonate, magnesium nitrate, magnesium sulfate, and magnesium silicate is selected from at least one of the bioactive glass composition and.  8. Wherein any one of claims 1-7 bioactive glass composition, the source of phosphorus, phosphorus pentoxide, anhydrous ammonium phosphate, trimethyl phosphate, triethyl phosphate, and at least one of phosphoric acid, phosphorus pentoxide or phosphorus source is selected from the other and is a bioactive glass composition.  9. Wherein one of the preceding claims claims 1-8 bioactive glass composition, and a fluorine source, calcium fluoride, magnesium fluoride, trifluoroacetate, hexafluorophosphate, ammonium hexafluorophosphate and at least one selected from a bioactive glass composition and.  10. Claims 1-9 of according to any one of bioactive glass composition, the molar % of 0-10, Na, K, Li, Ru, Cs, Fr, Sr, Bi, Zn, Ag, B, cu, Mn, Fe, wherein at least one of doped Ti characterized in that the bioactive glass composition.  11. Wherein any one of claims 1-10 bioactive glass composition, the additive-doped each mole %, 0-5 mol % and between the composition and the bioactive glass.  12. Claims 1-11 of according to any one of bioactive glass composition, - Na2 O、K2 O、SiO2 、CaO、MgO、P2 O5 、Ru2 O、Cs2 O、Fr2 O、SrO、Bi2 O3 、ZnO、Ag2 O、B2 O3 、Cu2 O、MnO2 、Fe2 O3 、TiO2 oxide; - tetraethyl orthosilicate, tetramethyl orthosilicate, titanium isopropoxide or alkoxides; - NaOH, Ca (OH)2 、Mg(OH)2 、Fe(OH)3 hydroxides; - Na2 CO3 、K2 CO3 、CaCO3 、MgCO3 、SrCO3 carbonates such; - NaNO3 、Ag(NO3) 、Mg(NO3)2 、Ca(NO3)2 、Ca(NO3)2, 4H2 O、Ag2 (NO3)2 、Fe(NO3)3 、Fe(NO3)3, 9H2 OTecator such as; - na2 SO4 、K2 SO4 、CaSO4 such as sulfate; - ammonium dihydrogen phosphate, trimethyl phosphate, triethyl phosphate, phosphoric acid, disodium hydrogen phosphate, 1 sodium phosphate, sodium tripolyphosphate, sodium hexametaphosphate salt of phosphoric acid or other phosphorus precursor; - calcium fluoride, magnesium fluoride, trifluoroacetic acid, hexafluorophosphoric acid, hexafluorophosphoric acid or ammonium fluoride or other fluorine precursor; - CaCl2 、MgCl2 、FeCl3 chloride or; - sodium borate decahydrate and the like of the boric acid salt; characterized in comprising a bioactive glass composition.  13. Claims 1-12 of any one of the bioactive glass composition, comprising a polymer resin composition characterized in that the bioactive glass.  14. Wherein one of the preceding claims claims 1-13 bioactive glass composition, characterized in that the powder composition and the bioactive glass.  15. Wherein any one of claims 1-14 bioactive glass composition comprising, a particle size less than 500 μm characterized in that the bioactive glass composition.  16. Claims 1-15 of according to any one of bioactive glass composition, the injectable calcium phosphate cement initiatively or polymethyl methacrylate and further comprises a bioactive glass composition.  17. Any one of claims 1-16 bioactive glass of the composition, characterized in that the drug used in the bioactive glass composition.  18. Wherein any one of claims 1-17 bioactive glass composition, an artificial organ, implant, a toothpaste, a dental cement, is used as a bone filler characterized in that the bioactive glass composition.  19. Claims 1-18 of any one of the bioactive glass composition, used in the synthesis of bone tissue in vitro characterized in that the bioactive glass composition.  20. Claims 1-19 of any one of the bioactive glass composition, an implant, i.e., an orthopedic and a dental prosthesis and used as a coating of a bioactive glass composition.  21. Wherein one of the preceding claims claims 1-20 bioactive glass composition, an artificial organ, a cobalt chromium alloy, stainless steel, titanium alloys such as Ti6Al4V, polymeric materials, ceramic materials, or mixtures thereof and is formed from a bioactive glass composition.  22. Any one of claims 1-21 bioactive glass comprising the composition of said glass material.  23. Claims 1-22 according to any one of bioactive glass and a composition comprising, fibers, net, mesh, or disk.  24. Claims 1-23 according to any one of bioactive glass to the method of preparation of the composition, - components, preferably, oxide, carbonate, nitrate, sulfate, fluoride from a mixture of the batch, the temperature in the range of 1050-1600 °C, and melts at time interval 1-2; - mold, preferably, made of graphite or metal mold to a mold, pouring the melt, to obtain a bioactive glass BULK; characterized in that the method comprises.  25. Method according to claim 25, 400-700 at a temperature of, preferably, at a temperature range of 500-600 °C, physiological activity further comprises the step of annealing the glass BULK characterized.  26. Any one of claims 1-25 bioactive glass composition of the method, in anhydrous ethanol -, alkoxide, phosphate, fluoride, nitrate, chloride, sulfate, oxide, and a step of dissolving the compound acid; and - the step of adding water and a catalyst; - forming a colloid suspension; NiCoCrAlY polymerized -; polymer growth through metal-oxo -, the inorganic colloidal material dispersed in a solvent to manufacture, to form the porous three-dimensional structure to form the 3; - and aging, and forming a hard gel; - and performing a heat treatment; characterized in that the method comprises.  27. The bioactive glass composition according to claim 26 producing, in the liquid phase or vapor phase characterized in that the method using water.  28. Wherein the bioactive glass composition according to claims 26 or 27 method, an acid or a base as catalyst characterized in that the method is used.  29. Claims 26-28 of any one of the bioactive glass composition or the method of manufacturing the, tetraethyl orthosilicate and tetramethyl orthosilicate/silicon dioxide as a source or the like characterized in that the method is used as alkoxide.
法律状态
(JP2014512325) LEGAL DETAILS FOR JP2014512325  Actual or expected expiration date=2016-10-25    Legal state=DEAD    Status=REVOKED     Event publication date=2012-04-05  Event code=JP/APP  Event indicator=Pos  Event type=Examination events  Application details  Application country=JP JP2014503262  Application date=2012-04-05  Standardized application number=2014JP-0503262     Event publication date=2014-05-22  Event code=JP/A  Event indicator=Pos  Event type=Examination events  Published application  Publication country=JP  Publication number=JP2014512325  Publication stage Code=A  Publication date=2014-05-22  Standardized publication number=JP2014512325     Event publication date=2015-04-02  Event code=JP/A621  Event indicator=Pos  Event type=Examination events  Written request for application examination  Effective date of the event=2015-04-02  JAPANESE INTERMEDIATE CODE: A621     Event publication date=2016-03-24  Event code=JP/A977  Event type=Examination events  Report on retrieval  Effective date of the event=2016-03-24  JAPANESE INTERMEDIATE CODE: A971007     Event publication date=2016-04-12  Event code=JP/A131  Event indicator=Neg  Event type=Examination events  Notification of reasons for refusal  Effective date of the event=2016-04-12  JAPANESE INTERMEDIATE CODE: A131     Event publication date=2016-07-08  Event code=JP/A601  Event type=Examination events  Written request for extension of term  Effective date of the event=2016-07-08  JAPANESE INTERMEDIATE CODE: A601     Event publication date=2016-08-31  Event code=JP/A521  Event type=Restitution or restoration  Written amendment  Effective date of the event=2016-08-31  JAPANESE INTERMEDIATE CODE: A523     Event publication date=2016-10-25  Event code=JP/A02  Event indicator=Neg  Event type=Event indicating Not In Force  Decision of refusal  Effective date of the event=2016-10-25  JAPANESE INTERMEDIATE CODE: A02
专利类型码
A
国别省市代码
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