(IN2011DN00518) 1. A method of designing a selective pest control composition, comprising the steps of: selecting a target pest with a first molecular target and a non-target organism with a second molecular target; identifying at least two active agents for the composition, wherein the active agents in combination have a first activity upon the first molecular target in a target pest; and a second activity upon the second molecular target in the non-target organism, and confirming that the at least two active agents have a synergistic effect upon the target pest and do not have a synergistic effect upon the non-target organism, wherein the confirming step indicates that the composition is selective for the target pest over the non-target organism. 2. The method of Claim 1, wherein the first molecular target is substantially absent in the non-target organism. 3. The method of Claim 1, wherein the first molecular target is also present in the non-target oragnism. 4. The method of Claim 1, wherein the first and second activities of the active agents are provided as LD50 5. The method of Claim 4, wherein the ratio of LD50 for the target pest relative to the LD50 for the non-target organism is 0.5. 6. The method of Claim 4, wherein the ratio of LD50 for the target pest relative to the LD50 for the non-target organism is 0.1. 7. The method of Claim 4, wherein the ratio of LD50 for the target pest relative to the LD50 for the non-target organism is 0.05. 8. The method of Claim 4, wherein the ratio of LD50 for the target pest relative to the LD50 for the non-target organism is 0.02. 9. The method of Claim 4, wherein the ratio of LD50 for the target pest relative to the LD50 for the non-target organism is 0.01. 10. The method of Claim 1, wherein the confirming step comprises confirming that the agents in combination have an effect in the non-target organism selected from the group consisting of: an antagonistic effect, a non-additive effect, and an additive effect. 11. The method of Claim 1, wherein the first molecular target is a G-protein coupled receptor. 12. The method of Claim 11, wherein the G-protein coupled receptor is selected from the group consisting of: a tyramine receptor, an octopamine receptor, olfactory receptor Or 83b and olfactory receptor 43a. 13. A method of developing a selective pest control composition, comprising the steps of: selecting a target pest for selective control by the composition, and a non-target organism to be substantially unaffected by the composition; identifying at least two active agents for the composition, wherein the active agents in combination have a synergistic effect within the target pest; and confirming that the identified active agents do not have a synergistic effect within the non-target organism, to establish that the composition is selective of the target pest over the non-target organism. 14. A method of designing a selective pest control composition, comprising the steps of: selecting a target pest for selective control by the composition and a non-target organism to be substantially unaffected by the composition; identifying at least two active agents for the composition, wherein the active agents in combination have a first activity upon the target pest; and a second activity upon the non-target organism, and confirming that the at least two active agents have a synergistic effect upon the target pest and do not have a synergistic effect upon the non-target organism, wherein the confirming step indicates that the composition is selective for the target pest over the non-target organism. 15. A method of developing a low-resistance pest control formulation against a target pest, comprising the steps of: selecting a target pest, the pest having at least a first and a second molecular target, where the molecular targets are under genetic control; selecting at least two active agents, wherein a first active agent interacts with the first molecular target under genetic control and a second active agent interacts with the second molecular target under genetic control; and combining the two active agents in a formulation, wherein the agents in the formulation act upon the target pest in a synergistic manner, and wherein resistance to the formulation in an individual target pest requires two separate genetic lesions divergent from a non-resistant population of the pest.
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