Pest-control compositions and methods having high target and low nontarget activity 机翻标题: 暂无翻译,请尝试点击翻译按钮。

公开号/公开日
IN0518/DELNP/2011 A 2012-02-10 [IN2011DN00518] / 2012-02-10
申请号/申请日
2011IN-DN00518 / 2011-01-21
发明人
ENAN ESSAM;
申请人
TYRATECH;
主分类号
IPC分类号
A01N-025/00
摘要
(IN2011DN00518) Embodiments of the invention relate to compositions and methods for selective pest control wherein the compositions include active agents that in combination have a first activity against a selected target pest and a second activity against a selected non-target organism and wherein the first activity is greater than the second.  Further embodiments of the invention relate to a method for developing selective pest control compositions and low-resistance pest control compositions.
机翻摘要
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地址
代理人
代理机构
;
优先权号
2008US-61082601 2008-07-22
主权利要求
(IN2011DN00518)  1. A method of designing a selective pest control composition, comprising the steps of: selecting a target pest with a first molecular target and a non-target organism with a second molecular target;  identifying at least two active agents for the composition, wherein the active agents in combination have a first activity upon the first molecular target in a target pest;  and a second activity upon the second molecular target in the non-target organism, and confirming that the at least two active agents have a synergistic effect upon the target pest and do not have a synergistic effect upon the non-target organism, wherein the confirming step indicates that the composition is selective for the target pest over the non-target organism. 2. The method of Claim 1, wherein the first molecular target is substantially absent in the non-target organism. 3. The method of Claim 1, wherein the first molecular target is also present in the non-target oragnism. 4. The method of Claim 1, wherein the first and second activities of the active agents are provided as LD50 5. The method of Claim 4, wherein the ratio of LD50 for the target pest relative to the LD50 for the non-target organism is 0.5. 6. The method of Claim 4, wherein the ratio of LD50 for the target pest relative to the LD50 for the non-target organism is 0.1. 7. The method of Claim 4, wherein the ratio of LD50 for the target pest relative to the LD50 for the non-target organism is 0.05. 8. The method of Claim 4, wherein the ratio of LD50 for the target pest relative to the LD50 for the non-target organism is 0.02. 9. The method of Claim 4, wherein the ratio of LD50 for the target pest relative to the LD50 for the non-target organism is 0.01. 10. The method of Claim 1, wherein the confirming step comprises confirming that the agents in combination have an effect in the non-target organism selected from the group consisting of: an antagonistic effect, a non-additive effect, and an additive effect. 11. The method of Claim 1, wherein the first molecular target is a G-protein coupled receptor. 12. The method of Claim 11, wherein the G-protein coupled receptor is selected from the group consisting of: a tyramine receptor, an octopamine receptor, olfactory receptor Or 83b and olfactory receptor 43a. 13. A method of developing a selective pest control composition, comprising the steps of: selecting a target pest for selective control by the composition, and a non-target organism to be substantially unaffected by the composition;  identifying at least two active agents for the composition, wherein the active agents in combination have a synergistic effect within the target pest;  and confirming that the identified active agents do not have a synergistic effect within the non-target organism, to establish that the composition is selective of the target pest over the non-target organism. 14. A method of designing a selective pest control composition, comprising the steps of: selecting a target pest for selective control by the composition and a non-target organism to be substantially unaffected by the composition;  identifying at least two active agents for the composition, wherein the active agents in combination have a first activity upon the target pest;  and a second activity upon the non-target organism, and confirming that the at least two active agents have a synergistic effect upon the target pest and do not have a synergistic effect upon the non-target organism, wherein the confirming step indicates that the composition is selective for the target pest over the non-target organism. 15. A method of developing a low-resistance pest control formulation against a target pest, comprising the steps of: selecting a target pest, the pest having at least a first and a second molecular target, where the molecular targets are under genetic control;  selecting at least two active agents, wherein a first active agent interacts with the first molecular target under genetic control and a second active agent interacts with the second molecular target under genetic control;  and combining the two active agents in a formulation, wherein the agents in the formulation act upon the target pest in a synergistic manner, and wherein resistance to the formulation in an individual target pest requires two separate genetic lesions divergent from a non-resistant population of the pest.
法律状态
(IN2011DN00518) LEGAL DETAILS FOR IN0518/DELNP/2011  Actual or expected expiration date=2029-07-22    Legal state=ALIVE    Status=PENDING     Event publication date=2011-01-21  Event code=IN/APP  Event indicator=Pos  Event type=Examination events  Application details  Application country=IN IN0518/DELNP/2011  Application date=2011-01-21  Standardized application number=2011IN-DN00518     Event publication date=2012-02-10  Event code=IN/A  Event indicator=Pos  Event type=Examination events  Application laid open  Publication country=IN  Publication number=IN0518/DELNP/2011  Publication stage Code=A  Publication date=2012-02-10  Standardized publication number=IN2011DN00518
专利类型码
A
国别省市代码
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