Recent Advances in the Biginelli Dihydropyrimidine Synthesis.New tricks from an Old Dog 机翻标题: 暂无翻译,请尝试点击翻译按钮。

来源
accounts of chemical research
年/卷/期
2000 / V.33 / N.12
页码
879-888
作者单位
Institute of Chemistry,Karl-Franzens-University Graz,Heinrichstrasse 28,A-8010 Graz,Austria;
作者
C.Oliver Kappe;
摘要
In 1893,P.Biginelli reported the synthesis of functionalized 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) via three-component condensation reaction of an aromatic aldehyde,urea,and ethyl acetoacetate.In the past decade,this long-neglected multicomponent reaction has experienced a remarkable revival,mainly due to the interesting pharmacological properties associated with this dihydropyrimidine scaffold.In this Account,we highlight recent developments in the BIginelli reaction in areas such as solid-phase synthesis,combinatorial chemistry,and natural product synthesis.
机翻摘要
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正文
C.Oliver Kappe; Institute of Chemistry,Karl-Franzens-University Graz,Heinrichstrasse 28,A-8010 Graz,Austria; accounts of chemical research; V.33 N.12 2000; 879-888
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