Discovering time-trends of the German populations exposure to contaminants by analysis of human samples of the German Environmental Specimen Bank (ESB) 机翻标题: 暂无翻译,请尝试点击翻译按钮。

来源
Toxicology Letters: An International Journal Providing a Forum for Original and Pertinent Contributions in Toxicology Research
年/卷/期
2018 / 298 /
页码
194-200
ISSN号
0378-4274
作者单位
Friedrich Alexander Univ Erlangen Nurnberg, Inst & Clin Occupat Social & Environm Med IPASUM;IBMT, Fraunhofer Inst Biomed Engn, Sulzbach, Germany;Friedrich Alexander Univ Erlangen Nurnberg, Inst & Clin Occupat Social & Environm Med IPASUM;IBMT, Fraunhofer Inst Biomed Engn, Sulzbach, Germany;UBA, German Environm Agcy, Berlin, Germany;UBA, German Environm Agcy, Berlin, Germany;
作者
Goeen, Thomas;Lermen, Dominik;Hildebrand, Joerg;Bartel-Steinbach, Martina;Weber, Till;Kolossa-Gehring, Marike;
摘要
The German Environmental Specimen Bank (ESB) is a monitoring instrument of the German Federal Ministry for the Environment, Nature Conservation and Nuclear Safety. The permanent biobank facility is run since 1981 containing environmental and human samples from Germany. All samples are collected according to standard operating procedures (SOP). An standardized annual collection of human samples at four different regional sites of the country has been established since 1997. Routine sampling is done once a year, recruiting healthy non occupationally exposed students aged 20-29 years, in an equal gender distribution. The number of participants recruited is approximately 120 students per site and year. Directly after the annual sampling process, the human samples are analyzed for selected environmental chemicals. The time-trends of lead in blood, mercury and pentachlorophenol in 24 h-urine and polychlorinated biphenyls in plasma demonstrated a decrease of exposure during the last two decades by about 40-90 percent. In parallel retrospective studies using cryo-archived samples revealed increasing time trends of emerging chemicals used as substitutes for regulated toxicants.
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关键词/主题词
Human biomonitoring;HBM;Biobank;Environmental Specimen Bank;Chemical exposure;
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