Use of organ for storage Neureguliii 机翻标题: 暂无翻译,请尝试点击翻译按钮。

源语言标题
(JP5421916) 臓器​保存​の​ため​の​ニューレグリン​の​使用
公开号/公开日
JP2010539107 A 2010-12-16 [JP2010539107]JP5421916 B2 2014-02-19 [JP5421916] / 2010-12-162014-02-19
申请号/申请日
2010JP-0524335 / 2008-09-12
发明人
Don Guzman programming boric;
申请人
ZENSAN SCIENCE & TECHNOLOGY;
主分类号
IPC分类号
A01N-001/02A61K-038/22A61P-009/04A61P-009/10C12N-015/09
摘要
(JP5421916) The invention relates to a composition for perfusion, preservation or reperfusion of an organ for transplantation, comprising a preservation solution and an effective amount of neuregulin.  The invention further relates to the use of neuregulin for preserving an organ for transplantation, increasing the relaxation speed of heart and treating chronic heart failure in a subject.  (From EP2586305 A1)
机翻摘要
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地址
代理人
代理机构
;
优先权号
2007US-60993566 2007-09-12 2008WO-CN01610 2008-09-12
主权利要求
(JP5421916) 1. And the preservative solution comprises Neureguliii, perfusion of the organ for transplantation, storage, or the composition for reperfusion in, the preservation solution, Celsior solution, Krebs, Henseleit solution, normal saline, University of Wisconsin solution, St, 2 liquid first thomas, Collins solution, and is selected from the group consisting of a solution KEMAMIDE, wherein the composition.  2. Wherein the preservation solution, Celsior solution, a composition according to claim 1.  3. Wherein the preservation solution, Krebs, Henseleit solution, a composition according to claim 1.  4. Is Neureguliii, comprising the amino acid sequence of SEQ ID NO:1, a composition according to claim 1.  5. Is Neureguliii, 10-20 nm is at a concentration, a composition according to claim 1.  6. Is Neureguliii, present in a concentration of 14 nm, of the composition according to claim 1.  7. Method of organ preservation for transplantation, organ comprising contacting Neureguliii emphasizer, method.  8. Wherein the organ, a heart, wherein 7method.  9. 1 Comprises the amino acid sequence of SEQ Neureguliii, wherein 7method.  10. Is Neureguliii, AKT signaling pathway in an amount sufficient to activate the subjected, wherein 7method.
法律状态
(JP5421916) LEGAL DETAILS FOR JP2010539107  Actual or expected expiration date=2028-09-12    Legal state=ALIVE    Status=GRANTED     Event publication date=2008-09-12  Event code=JP/APP  Event indicator=Pos  Event type=Examination events  Application details  Application country=JP JP2010524335  Application date=2008-09-12  Standardized application number=2010JP-0524335     Event publication date=2010-12-16  Event code=JP/A  Event type=Examination events  Published application  Publication country=JP  Publication number=JP2010539107  Publication stage Code=A  Publication date=2010-12-16  Standardized publication number=JP2010539107     Event publication date=2011-09-09  Event code=JP/A521  Event type=Restitution or restoration  Written amendment  Effective date of the event=2011-09-08  JAPANESE INTERMEDIATE CODE: A523     Event publication date=2011-09-09  Event code=JP/A621  Event indicator=Pos  Event type=Examination events  Written request for application examination  Effective date of the event=2011-09-08  JAPANESE INTERMEDIATE CODE: A621     Event publication date=2013-02-18  Event code=JP/A977  Event type=Examination events  Report on retrieval  Effective date of the event=2013-02-18  JAPANESE INTERMEDIATE CODE: A971007     Event publication date=2013-03-12  Event code=JP/A131  Event indicator=Neg  Event type=Examination events  Notification of reasons for refusal  Effective date of the event=2013-03-12  JAPANESE INTERMEDIATE CODE: A131     Event publication date=2013-06-14  Event code=JP/A602  Event type=Examination events  Written permission of extension of term  Effective date of the event=2013-06-13  JAPANESE INTERMEDIATE CODE: A602     Event publication date=2013-09-12  Event code=JP/A521  Event type=Restitution or restoration  Written amendment  Effective date of the event=2013-09-11  JAPANESE INTERMEDIATE CODE: A523     Event publication date=2013-10-29  Event code=JP/A01  Event indicator=Pos  Event type=Event indicating In Force  Written decision to grant a patent or to grant a registration (utility model)  Effective date of the event=2013-10-29  JAPANESE INTERMEDIATE CODE: A01     Event publication date=2013-11-28  Event code=JP/A61  Event indicator=Pos  Event type=Event indicating In Force  First payment of annual fees (during grant procedure)  Effective date of the event=2013-11-22  JAPANESE INTERMEDIATE CODE: A61     Event publication date=2014-02-19  Event code=JP/B2  Event indicator=Pos  Event type=Event indicating In Force  Published granted patent (Second level)  from 01-03-1996 onwards (Published examined patent application (Second level) 1971-1996)  Publication country=JP  Publication number=JP5421916  Publication stage Code=B2  Publication date=2014-02-19  Standardized publication number=JP5421916     Event publication date=2016-08-04  Event code=JP/S531  Event type=Change of name or address  Written request for registration of change of domicile JAPANESE INTERMEDIATE CODE: R313531     Event publication date=2016-08-04  Event code=JP/S533  Event type=Change of name or address  Written request for registration of change of name JAPANESE INTERMEDIATE CODE: R313533     Event publication date=2016-08-15  Event code=JP/R350  Event type=Change of name or address  Event type=Reassignment  Written notification of registration of transfer JAPANESE INTERMEDIATE CODE: R350     Event publication date=2016-11-01  Event code=JP/R250  Event indicator=Pos  Event type=Payment or non-payment notifications  Receipt of annual fees JAPANESE INTERMEDIATE CODE: R250     Event publication date=2017-11-07  Event code=JP/R250  Event indicator=Pos  Event type=Payment or non-payment notifications  Receipt of annual fees JAPANESE INTERMEDIATE CODE: R250
专利类型码
AB2
国别省市代码
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