(JP5421916) The invention relates to a composition for perfusion, preservation or reperfusion of an organ for transplantation, comprising a preservation solution and an effective amount of neuregulin. The invention further relates to the use of neuregulin for preserving an organ for transplantation, increasing the relaxation speed of heart and treating chronic heart failure in a subject. (From EP2586305 A1)
(JP5421916) 1. And the preservative solution comprises Neureguliii, perfusion of the organ for transplantation, storage, or the composition for reperfusion in, the preservation solution, Celsior solution, Krebs, Henseleit solution, normal saline, University of Wisconsin solution, St, 2 liquid first thomas, Collins solution, and is selected from the group consisting of a solution KEMAMIDE, wherein the composition. 2. Wherein the preservation solution, Celsior solution, a composition according to claim 1. 3. Wherein the preservation solution, Krebs, Henseleit solution, a composition according to claim 1. 4. Is Neureguliii, comprising the amino acid sequence of SEQ ID NO:1, a composition according to claim 1. 5. Is Neureguliii, 10-20 nm is at a concentration, a composition according to claim 1. 6. Is Neureguliii, present in a concentration of 14 nm, of the composition according to claim 1. 7. Method of organ preservation for transplantation, organ comprising contacting Neureguliii emphasizer, method. 8. Wherein the organ, a heart, wherein 7method. 9. 1 Comprises the amino acid sequence of SEQ Neureguliii, wherein 7method. 10. Is Neureguliii, AKT signaling pathway in an amount sufficient to activate the subjected, wherein 7method.
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