(WO201916377) Lipophilic macrocyclic ligands, complexes thereof, and uses of same 机翻标题: 暂无翻译,请尝试点击翻译按钮。

源语言标题
(WO201916377) Lipophilic macrocyclic ligands, complexes thereof, and uses of same
公开号/公开日
WO2019016377 / 2019-01-24
申请号/申请日
WOEP2018069784 / 2018-07-20
发明人
ROUSSEAUX OLIVIERFOUGERE OLIVIERCATOEN SARAH;
申请人
GUERBET;
主分类号
IPC分类号
A61K-049/00 A61K-051/00 A61P-035/00 C07D-257/02
摘要
(WO201916377) The present invention relates to novel lipophilic macrocyclic ligands, the complexes thereof, in particular radioactive complexes, and the uses of same in medical imaging and/or in therapy, in particular in interventional radiology.
机翻摘要
暂无翻译结果,您可以尝试点击头部的翻译按钮。
地址
代理人
(WO201916377) BLOT, Philippe et al. ([FR])
代理机构
;
优先权号
2017FR-0056932
主权利要求
(WO201916377) 1. CLAIMS 1. Compound of general formula (I) below:   wherein:   - R1is methyl or (the C6-C10) aryl;   - R3, R is4and R5are selected independently of one another from the group consisting of: hr, (the C1-C20) alkyl, (the C2-C20) alkenyl, (the C2-C20) alkynyl, (the C6-C10) aryl, (the C1-C20) alkylene - (the C6-C10) aryl, (the C2-C20) alkenylene - (the C6-C10) aryl and (the C2-C20) alkynylene - (the C6-C10) aryl;   said alkyl groups, alkenyl, alkynyl, alkylene, alkenylene and alkynylene radicals R is3, R is4and R5which may optionally comprise one or more (the C6-C10) arylene (sec) and/or one or more (the C5-C10) cycloalkylene (sec) in their chain; and   said alkyl groups, alkenyl, alkynyl, aryl, alkylene, alkenylene and alkynylene radicals R is3, R is4and R5is optionally substituted (sec) by one or more substituents (sec) selected from the group consisting of:   halogen, halo (the C1-C20) alkyl, (the C1-C20) alkyl, (the C2-C20) alkenyl, (the C2-C20) alkynyl; groups are alkyl, alkenyl and alkynyl, which may optionally comprise one or more (the C6-C10) arylene (sec) in their chain; - a is a group - (CH2)n- which may optionally comprise one or more (the C6-C10) arylene (sec) in its chain;   n is an integer from 0 to 15; and   m is an integer from 1 to 10; or a pharmaceutically acceptable salt thereof or an optical isomer thereof or a geometrical isomer thereof or a tautomer thereof or a solvate thereof. 2. Compound of formula (I) according to claim 1, wherein when R is1is methyl, then n is an integer ranging from 4 to 8. 3 of. Compound according to claim 1, of general formula (- I-1) below:   wherein:   - R1, R is3, R is5, n and m are as defined in claim 1, with n being preferably equal to 6 or equal to 8;   B is a bond, an (the C1-C20) alkylene, an (the C2-C20) alkenylene or (the C2-C20) alkynylene; and   - R6, R is7and R8are chosen, independently of each other, selected from H and (the C1- C20) alkyl. 4. Compound according to claim 1, of general formula (- I-2) or (- I-3) below:   in which R3, R is4, R is5and m are as defined in claim 1. 5. Compound of formula (I) according to claim 1, selected from the group consisting of the following compounds:   or a pharmaceutically acceptable salt thereof. 6. Complex of a compound of formula (I) or a salt thereof according to any one of claims 1 to 5, with M; M being a chemical element, preferably a radioelement. 7. Complex according to claim 6, for use in the treatment of cancers, in particular cancers of the liver. 8. Pharmaceutical composition comprising a compound according to any one of claims 1 to 5 or a complex according to any one of claims 6 to 7 and optionally one or more excipient (sec) pharmaceutically acceptable (sec). 9. Pharmaceutical composition according to claim 8, further comprising an oil iodine, iodinated oil comprising in particular an ethyl esters of iodinated fatty acids of poppyseed oil.
法律状态
PENDING
专利类型码
A1
国别省市代码
若您需要申请原文,请登录。

最新评论

暂无评论。

登录后可以发表评论

意见反馈
返回顶部