Antibodies against immunogenic glycopeptides, composition comprising the same and use thereof 机翻标题: 暂无翻译,请尝试点击翻译按钮。

公开号/公开日
WO2015143123 A2 2015-09-24 [WO2015143123]WO2015143123 A3 2015-11-26 [WO2015143123] / 2015-09-242015-11-26
申请号/申请日
2015WO-US21413 / 2015-03-19
发明人
CHANG CHI-LONG;WU CHAO-CHIH;
申请人
DCB;MACKAY MEMORIAL HOSPITAL OF TAIWAN PRESBYTERIAN CHURCH & MACKAY MEMORIAL SOCIAL WORK FOUNDATION;
主分类号
IPC分类号
A61K-039/00A61K-039/40C07K-016/00
摘要
(WO2015143123) Disclosed herein are antibodies which specifically bind to at least one epitope defined by the immunogenic glycopeptide.  Other aspects of the present disclosure are pharmaceutical composition comprising the antibody; and method for preventing and/or treating Globo-H- positive cancer.
机翻摘要
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地址
代理人
代理机构
;
优先权号
2014US-61955216 2014-03-19
主权利要求
(WO2015143123)  1. An isolated anti-Globo H antibody or an antigen-binding portion thereof, comprising a humanized anti-Globo H antibody or an antigen-binding portion thereof, comprising at least one of a heavy chain complementarity determining region 1 (H-CDR1) consisting of the aminoacid residues of GFSLSTFDMGVG (SEQ ID NO: 1), GSSLSTFDVGVG (SEQ ID NO: 2), GFSLGTFDLGIG (SEQ ID NO: 3), GFSLSTFDLGIG (SEQ ID NO: 4) or a variant having aminoacid sequence with at least 80% identity to any of SEQ ID NOs: 1 to 4; a heavy chain CDR2 (H-CDR2) consisting of the aminoacid residues of HIWWDDDKYYNPA (SEQ ID NO:5), HIWGDDDKYYNPA (SEQ ID NO: 6) or a variant having aminoacid sequence with at least 80% identity to any of SEQ ID NOs: 5 and 6; and a heavy chain CDR3 (H-CDR3) consisting of the aminoacid residues of LYGNYLTSFYCDY (SEQ ID NO: 7), or LSGNYLTSFYCDY (SEQ ID NO: 8), LYGNYLRSYYCDY (SEQ ID NO: 9) or a variant having aminoacid sequence with at least 80% identity to any of SEQ ID NOs: 7 to 9; and at least one of a light chain CDR1 (L-CDR1) consisting of the aminoacid residues of SASSSVSYMH (SEQ ID NO: 10), SASSRVSYMH (SEQ ID NO: l l), SARSSVSYMH (SEQ ID NO: 12), RASSSVSYMH (SEQ ID NO: 13) or a variant having aminoacid sequence with at least 80% identity to any of SEQ ID NOs: 10 to 13; a light chain CDR2 (L-CDR2) consisting of the aminoacid residues of ATSNLAS (SEQ ID NO: 14), WTSDRYS (SEQ ID NO: 15), DTSKLAS (SEQ ID NO: 16) or a variant having aminoacid sequence with at least 80% identity to any of SEQ ID NOs: 14 to 16; and a light chain CDR3 (L-CDR3) consisting of the aminoacid residues QQWSSNPFT (SEQ ID NO: 17), QQWSSNPLT (SEQ ID NO: 18), QQHLHIPYT (SEQ ID NO: 19) or a variant having aminoacid sequence with at least 80% identity to any of SEQ ID NOs: 17 to 19; such that said isolated recombinant antibody or antigen-binding portion thereof binds to Globo H.
法律状态
(WO2015143123) LEGAL DETAILS FOR WO2015143123  Actual or expected expiration date=2017-09-19    Legal state=ALIVE    Status=PENDING     Event publication date=2015-03-19  Event code=WO/APP  Event indicator=Pos  Event type=Examination events  Application details  Application country=WO WOUS2015021413  Application date=2015-03-19  Standardized application number=2015WO-US21413     Event publication date=2015-09-24  Event code=WO/A2  Event type=Examination events  International application published with declaration under Article 17 (2) (a)  Publication country=WO  Publication number=WO2015143123  Publication stage Code=A2  Publication date=2015-09-24  Standardized publication number=WO2015143123     Event publication date=2015-11-26  Event code=WO/A3  Event indicator=Pos  Event type=Examination events  Later publication of ISR with revised front page  Publication country=WO  Publication number=WO2015143123  Publication stage Code=A3  Publication date=2015-11-26  Standardized publication number=WO2015143123  LEGAL DETAILS FOR DESIGNATED STATE AU2015231256  Actual or expected expiration date=2035-03-19    Legal state=ALIVE    Status=PENDING   Corresponding cc:  Designated or member state=AU Corresponding appl: AU2015231256  Application date in the designated or member state=2015-03-19   Application number in the designated or member state=2015AU-0231256 Corresponding cc:  Designated or member state=AU Corresponding pat: AU2015231256  Publication stage code in the designated or member state=A1  Publication date in the designated or member state=2016-09-22   Publication number in the designated or member state=AU2015231256    Event publication date=2016-09-22  Event code=WO/ENP  Event type=Entry into national phase  Entry into the national phase in: Corresponding cc:  Designated or member state=AU  LEGAL DETAILS FOR DESIGNATED STATE CA2943333  Actual or expected expiration date=2035-03-19    Legal state=ALIVE    Status=PENDING   Corresponding cc:  Designated or member state=CA Corresponding appl: CA2943333  Application date in the designated or member state=2015-03-19   Application number in the designated or member state=2015CA-2943333 Corresponding cc:  Designated or member state=CA Corresponding pat: CA2943333  Publication stage code in the designated or member state=A1  Publication date in the designated or member state=2015-09-24   Publication number in the designated or member state=CA2943333    Event publication date=2016-09-13  Event code=WO/ENP  Event type=Entry into national phase  Entry into the national phase in: Corresponding cc:  Designated or member state=CA  LEGAL DETAILS FOR DESIGNATED STATE CN106456766  Actual or expected expiration date=2035-03-19    Legal state=ALIVE    Status=PENDING   Corresponding cc:  Designated or member state=CN Corresponding appl: CN201580014575  Application date in the designated or member state=2015-03-19   Application number in the designated or member state=2015CN-80014575 Corresponding cc:  Designated 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European phase Corresponding cc:  Designated or member state=EP     Event publication date=2016-11-02  Event code=WO/121  Event type=Designated states  EP: The EPO has been informed by wipo that ep was designated in this application Corresponding cc:  Designated or member state=EP     Event publication date=2017-06-28  Event code=EP/STCHG  Patent Status changed by the national office Corresponding cc:  Designated or member state=EP  LEGAL DETAILS FOR DESIGNATED STATE IL  Actual or expected expiration date=2034-03-19    Legal state=ALIVE    Status=PENDING   Corresponding cc:  Designated or member state=IL Corresponding appl: IL247659    Event publication date=2016-09-06  Event code=WO/WWE  Event indicator=Pos  Event type=Entry into national phase  Wipo information: entry into national phase Corresponding cc:  Designated or member state=IL  LEGAL DETAILS FOR DESIGNATED STATE JP2017518958  Actual or expected expiration date=2035-03-19    Legal state=ALIVE    Status=PENDING   Corresponding cc:  Designated or member state=JP Corresponding appl: JP2016556306  Application date in the designated or member state=2015-03-19   Application number in the designated or member state=2016JP-0556306 Corresponding cc:  Designated or member state=JP Corresponding pat: JP2017518958  Publication stage code in the designated or member state=A  Publication date in the designated or member state=2017-07-13   Publication number in the designated or member state=JP2017518958    Event publication date=2016-09-06  Event code=WO/ENP  Event type=Entry into national phase  Entry into the national phase in: Corresponding cc:  Designated or member state=JP  LEGAL DETAILS FOR DESIGNATED STATE KR20170003912  Actual or expected expiration date=2035-03-19    Legal state=ALIVE    Status=PENDING   Corresponding cc:  Designated or member state=KR Corresponding appl: KR20167028309  Application date in the designated or member state=2015-03-19   Application number in the designated or member state=2016KR-7028309 Corresponding cc:  Designated or member state=KR Corresponding pat: KR20170003912  Publication stage code in the designated or member state=A  Publication date in the designated or member state=2017-01-10   Publication number in the designated or member state=KR20170003912    Event publication date=2016-10-12  Event code=WO/ENP  Event type=Entry into national phase  Entry into the national phase in: Corresponding cc:  Designated or member state=KR  LEGAL DETAILS FOR DESIGNATED STATE MX2016012124  Actual or expected expiration date=2035-03-19    Legal state=ALIVE    Status=PENDING   Corresponding cc:  Designated or member state=MX Corresponding appl: MX2016012124  Application date in the designated or member state=2015-03-19   Application number in the designated or member state=2016MX-PA12124 Corresponding cc:  Designated or member state=MX Corresponding pat: MX2016012124  Publication stage code in the designated or member state=A  Publication date in the designated or member state=2017-04-06   Publication number in the designated or member state=MX2016012124 LEGAL DETAILS FOR DESIGNATED STATE US2017107297  Actual or expected expiration date=2035-03-19    Legal state=ALIVE    Status=PENDING   Corresponding cc:  Designated or member state=US Corresponding appl: US15126945  Application date in the designated or member state=2015-03-19   Application number in the designated or member state=2015US-15126945 Corresponding cc:  Designated or member state=US Corresponding pat: US2017107297  Publication stage code in the designated or member state=A1  Publication date in the designated or member state=2017-04-20   Publication number in the designated or member state=US20170107297    Event publication date=2016-09-16  Event code=WO/WWE  Event indicator=Pos  Event type=Entry into national phase  Wipo information: entry into national phase Corresponding cc:  Designated or member state=US
专利类型码
A2A3
国别省市代码
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