Methods of screening compositions for potential insect control activity 机翻标题: 暂无翻译,请尝试点击翻译按钮。

公开号/公开日
US2005008714 A1 2005-01-13 [US20050008714]US7541155 B2 2009-06-02 [US7541155] / 2005-01-132009-06-02
申请号/申请日
2004US-10832022 / 2004-04-26
发明人
ENAN ESSAM;
申请人
TYRATECH;
主分类号
IPC分类号
A01N-027/00A01N-031/04A01N-031/08A01N-031/16A01N-035/02A01N-035/06A01N-037/44A01N-043/30A01N-049/00A01N-065/00G01N-033/53G01N-033/566G01N-033/567
摘要
(US7541155) The present invention comprises compositions, methods and cell lines related to controlling insects.  An embodiment of a composition comprises a plant essential oil and targets at least one receptor of insects chosen from tyramine receptor, Or83b olfactory receptor, and Or43a olfactory receptor, resulting in a change in the intracellular levels of cAMP, Ca2+, or both in the insects.
机翻摘要
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地址
代理人
代理机构
;
优先权号
2003US-60465320 2003-04-24 2003US-60532503 2003-12-24 2004US-10832022 2004-04-26
主权利要求
(US7541155) What is claimed is: 1.  A method of screening a composition for potential insect control activity, comprising: providing insect cells expressing olfactory receptor Or83b and a tyramine receptor;  adding said composition to the cells;measuring the binding affinity of said composition to the receptor;  and    selecting a composition having an affinity for either of said receptors, wherein said affinity is indicative of potential insect control activity. 2. A method of screening a composition for potential insect control activity comprising: providing insect cells expressing olfactory receptor Or83b and a tyramine receptor;  adding said composition to the cells;extracting intracellular cAMP or Ca2+ from the cells;measuring the intracellular cAMP or Ca2+ levels;comparing the intracellular cAMP or Ca2+ levels in cells treated with said composition to the intracellular cAMP or Ca2+ levels in untreated cells;  and    selecting a composition that causes a change in intracellular cAMP, Ca2+, or both via at least one of said receptors, wherein said change is indicative of potential insect control activity. 3. The method of claim 2, wherein the tyramine receptor is expressed from the nucleic acid sequence as set for the in SEQ ID NO:1. 4. The method of claim 2, wherein the olfactory receptor Or83b is expressed from the nucleic acid sequence as set forth in SEQ ID NO:5. 5. The method of claim 2, wherein intracellular cAMP is extracted from the cells and its levels are measured and compared. 6. The method of claim 2, wherein intracellular Ca2+ is extracted from the cells and its levels are measured and compared. 7. A method of screening a composition for potential insect control activity, comprising: providing insect cells expressing olfactory receptor 83b and a tyramine receptor;adding said composition to the cells;measuring a characteristic of the cells in the presence of the composition, wherein the characteristic results from an interaction between the composition and at least one of the said receptors and is indicative of a potential for insect control activity;  and    selecting a composition suitable for insect control based on the results of the measuring step. 8. The method of claim 7, wherein the characteristic is selected from the group consisting of: a binding affinity of the composition to the receptor;  a change in intracellular cAMP level;  and a change in intracellular Ca2+ level. 9. The method of claim 1, wherein the insect cells additionally express olfactory receptor 43a. 10. The method of claim 2, wherein the insect cells additionally express olfactory receptor 43a. 11. The method of claim 7, wherein the insect cells additionally express olfactory receptor 43a.
法律状态
(US7541155) LEGAL DETAILS FOR US2005008714  Actual or expected expiration date=2025-09-27    Legal state=ALIVE    Status=GRANTED     Event publication date=2004-04-26  Event code=US/APP  Event indicator=Pos  Event type=Examination events  Application details  Application country=US US10832022  Application date=2004-04-26  Standardized application number=2004US-10832022     Event publication date=2004-04-26  Event code=US/EXMR  Event type=Administrative notifications  USPTO Examiner Name Primary Examiner: LANDSMAN, ROBERT S    Event publication date=2004-04-26  Event code=US/ART  Event type=Administrative notifications  USPTO Art Group  ART=1647     Event publication date=2004-04-26  Event code=US/ENT  Event type=Administrative notifications  Entity Status Set to Undiscounted Business Entity Status: UNDISCOUNTED    Event publication date=2004-04-26  Event code=US/AIA  Event type=Administrative notifications  First Inventor File Indicated:  AIA=No     Event publication date=2004-04-26  Event code=US/DK  Event type=Examination events  Attorney Docket Number Docket Nbr: 0088524-001US0    Event publication date=2004-04-26  Event code=US/CUST  Event type=Examination events  Attorney/Agent Customer Number Customer Nbr: 77238    Event publication date=2004-07-16  Event code=US/IDS  Event type=Examination events  Event type=OAI  Information Disclosure Statement Filed    Event publication date=2004-08-16  Event code=US/AS  Event type=Change of name or address  Event type=Reassignment  Assignment Owner: VANDERBILT UNIVERSITY, TENNESSEE  Effective date of the event=2004-05-11  ASSIGNMENT OF ASSIGNORS INTEREST ASSIGNOR:ENAN, ESSAM REEL/FRAME:014993/0333     Event publication date=2004-08-23  Event code=US/APE  Event type=Corrections  Preliminary amendments    Event publication date=2005-01-13  Event code=US/A1  Event type=Examination events  Application published  Publication country=US  Publication number=US2005008714  Publication stage Code=A1  Publication date=2005-01-13  Standardized publication number=US20050008714     Event publication date=2005-02-04  Event code=US/DOCK  Event indicator=Pos  Event type=Examination events  Case Docketed to Examiner    Event publication date=2005-06-28  Event code=US/DOCK  Event indicator=Pos  Event type=Examination events  Case Docketed to Examiner    Event publication date=2006-02-27  Event code=US/APE  Event type=Corrections  Preliminary amendments    Event publication date=2006-10-02  Event code=US/RESTREQ  Event type=Examination events  Event type=Corrections  Event type=OAO  Restriction/Election Requirement    Event publication date=2006-12-11  Event code=US/ELC  Event type=Examination events  Event type=OAI  Response to Election / Restriction Filed    Event publication date=2006-12-11  Event code=US/136G  Event type=OAO  Request for Extension of Time - Granted    Event publication date=2007-03-05  Event code=US/RESTREQ  Event type=Examination events  Event type=Corrections  Event type=OAO  Restriction/Election Requirement    Event publication date=2007-03-08  Event code=US/EXIN  Event type=Examination events  Event type=OAO  Event type=INT  Examiner Interview Summary Record (PTOL - 413)    Event publication date=2007-04-11  Event code=US/ELC  Event type=Examination events  Event type=OAI  Response to Election / Restriction Filed    Event publication date=2007-05-07  Event code=US/DOCK  Event indicator=Pos  Event type=Examination events  Case Docketed to Examiner    Event publication date=2007-05-16  Event code=US/CTNF  Event type=Examination events  Event type=OA  Event type=OAO  Non-Final Rejection    Event publication date=2007-08-08  Event code=US/POAC  Event type=Change of name or address  Change in Power of Attorney (May Include Associate POA)    Event publication date=2007-11-16  Event code=US/CTNFR  Event type=Examination events  Event type=OAI  Response after Non-Final Action    Event publication date=2007-11-16  Event code=US/136G  Event type=OAO  Request for Extension of Time - Granted    Event publication date=2008-01-07  Event code=US/IDS  Event type=Examination events  Event type=OAI  Information Disclosure Statement Filed    Event publication date=2008-01-24  Event code=US/CTNF  Event type=Examination events  Event type=OA  Event type=OAO  Non-Final Rejection    Event publication date=2008-04-30  Event code=US/EXIN  Event type=Examination events  Event type=OAO  Event type=INT  Examiner Interview Summary Record (PTOL - 413)    Event publication date=2008-07-25  Event code=US/CTNFR  Event type=Examination events  Event type=OAI  Response after Non-Final Action    Event publication date=2008-08-25  Event code=US/136G  Event type=OAO  Request for Extension of Time - Granted    Event publication date=2008-10-03  Event code=US/IDS  Event type=Examination events  Event type=OAI  Information Disclosure Statement Filed    Event publication date=2008-10-09  Event code=US/CTFR  Event type=Examination events  Event type=OA  Event type=OAO  Final Rejection    Event publication date=2008-12-01  Event code=US/POAC  Event type=Change of name or address  Change in Power of Attorney (May Include Associate POA)    Event publication date=2008-12-12  Event code=US/EXIN  Event type=Examination events  Event type=OAO  Event type=INT  Examiner Interview Summary Record (PTOL - 413)    Event publication date=2009-01-08  Event code=US/DOCK  Event indicator=Pos  Event type=Examination events  Case Docketed to Examiner    Event publication date=2009-01-08  Event code=US/EXAC  Event type=Examination events  Event type=OAO  Examiner's Amendment Communication    Event publication date=2009-01-15  Event code=US/NOAM  Event indicator=Pos  Event type=Examination events  Event type=OAO  Mail Notice of Allowance    Event publication date=2009-02-12  Event code=US/ANA  Event type=Corrections  Event type=OAI  Amendment after Notice of Allowance (Rule 312)    Event publication date=2009-02-24  Event code=US/N271  Event type=Examination events  Event type=OAO  Response to Amendment under Rule 312    Event publication date=2009-04-01  Event code=US/AS  Event type=Change of name or address  Event type=Reassignment  Assignment Owner: TYRATECH, INC., FLORIDA  Effective date of the event=2007-05-23  MERGER ASSIGNOR:TYRATECH, LLC REEL/FRAME:022484/0916     Event publication date=2009-04-03  Event code=US/AS  Event type=Change of name or address  Event type=Reassignment  Assignment Owner: TYRATECH, LLC, FLORIDA  Effective date of the event=2007-05-01  ASSIGNMENT OF ASSIGNORS INTEREST ASSIGNOR:VANDERBILT UNIVERSITY REEL/FRAME:022503/0399     Event publication date=2009-04-10  Event code=US/ENT  Event type=Administrative notifications  Entity Status Set to Undiscounted    Event publication date=2009-04-13  Event code=US/APRDY  Event indicator=Pos  Event type=Examination events  Application Is Considered Ready for Issue    Event publication date=2009-05-13  Event code=US/PAT  Event indicator=Pos  Event type=Event indicating In Force  Patented Case    Event publication date=2009-05-13  Event code=US/ISSM  Event indicator=Pos  Event type=Examination events  Event type=OAO  Event type=Restitution or restoration  Issue Notification Mailed    Event publication date=2009-06-02  Event code=US/B2  Event indicator=Pos  Event type=Event indicating In Force  Granted patent as second publication  Publication country=US  Publication number=US7541155  Publication stage Code=B2  Publication date=2009-06-02  Standardized publication number=US7541155     Event publication date=2009-06-02  Event code=US/354  Event indicator=Pos  Event type=Extension of term of duration of protection  Patent term extended under  35 U.S.C 154(b) until/for Delays (A,B,C): 768  Overlap Delays: 0  Non Overlap Delays: 768   PTO Office Delays: 0  Applicant Delays: 249  Adjustment total:  Number of days of extension=519    Event publication date=2009-12-01  Event code=US/CC  Event type=Corrections  Event type=Restitution or restoration  Certificate of Correction - Post Issue Communication    Event publication date=2012-06-12  Event code=US/NMFP  Event type=Payment or non-payment notifications  Publication of First Notice of Maintenance Fees Payable. PAYMENT NOTICE YEAR:  Year of payment of annual fees=3     Event publication date=2012-11-20  Event code=US/FPAY  Event indicator=Pos  Event type=Event indicating In Force  Event type=Payment or non-payment notifications  Fee payment recorded   Annual fees payment date=2012-11-20     Year of payment of annual fees=4     Event publication date=2015-04-06  Event code=US/POAC  Event type=Change of name or address  Change in Power of Attorney (May Include Associate POA)    Event publication date=2016-06-14  Event code=US/NMFP  Event type=Payment or non-payment notifications  Publication of First Notice of Maintenance Fees Payable. PAYMENT NOTICE YEAR:  Year of payment of annual fees=7     Event publication date=2016-11-21  Event code=US/FPAY  Event indicator=Pos  Event type=Event indicating In Force  Event type=Payment or non-payment notifications  Fee payment recorded   Annual fees payment date=2016-11-21     Year of payment of annual fees=8
专利类型码
A1B2
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