来源

Journal of Biotechnology

年/卷/期

2016 / 222 /

页码

117-142

ISSN号

0168-1656

作者单位

Univ Montpellier, CNRS, ENSCM, IEM European Inst Membranes,UMR 5635, Pl E Bataillon, F-34095 Montpellier, France;Univ Montpellier, CNRS, ENSCM, IEM European Inst Membranes,UMR 5635, Pl E Bataillon, F-34095 Montpellier, France;Univ Montpellier, CNRS, ENSCM, IEM European Inst Membranes,UMR 5635, Pl E Bataillon, F-34095 Montpellier, France;Univ Montpellier, CNRS, ENSCM, IEM European Inst Membranes,UMR 5635, Pl E Bataillon, F-34095 Montpellier, France;Univ Montpellier, CNRS, ENSCM, IEM European Inst Membranes,UMR 5635, Pl E Bataillon, F-34095 Montpellier, France;

作者

Soussan, Laurence;Pen, Nakry;Belleville, Marie-Pierre;Marcano, Jose Sanchez;Paolucci-Jeanjean, Delphine;

摘要

Alkanes constitute one of the vastest reserves of raw materials for the production of fine chemicals. This paper focuses on recent advances in alkane biohydroxylation, i.e. the bioactivation of alkanes into their corresponding alcohols. Enzyme and whole-cell biocatalysts have been reviewed. Process considerations to implement such biocatalysts in bioreactors at large scale by coupling the bioconversion with cofactor regeneration and product removal are also discussed. (c) 2016 Elsevier B.V. All rights reserved.

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关键词/主题词

Alkanes;Biohydroxylation;Biocatalysts;Bioreactors;Cofactor regeneration;Alcohol removal;

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