Invasive Infections Due to Trichosporon: Species Distribution, Genotyping, and Antifungal Susceptibilities from a Multicenter Study in China 机翻标题: 暂无翻译,请尝试点击翻译按钮。

来源
Journal of Clinical Microbiology
年/卷/期
2019 / 57 / 2
ISSN号
0095-1137
作者单位
Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Clin Lab, Beijing, Peoples R China;Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Clin Lab, Beijing, Peoples R China;Natl Taiwan Univ, Coll Med, Natl Taiwan Univ Hosp, Dept Lab Med & Internal Med, Taipei, Taiwan;Westerdijk Fungal Biodivers Inst, Utrecht, Netherlands;Radboud Univ Nijmegen, Med Ctr, Canisius Wilhelmina Hosp, Ctr Expertise Mycol, Nijmegen, Netherlands;Westerdijk Fungal Biodivers Inst, Utrecht, Netherlands;Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Clin Lab, Beijing, Peoples R China;Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Clin Lab, Beijing, Peoples R China;Univ Messina, Div Anim Prod, Dept Vet Sci, Messina, Italy;Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Clin Lab, Beijing, Peoples R China;Westerdijk Fungal Biodivers Inst, Utrecht, Netherlands;Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Clin Lab, Beijing, Peoples R China;
作者
Guo, Li-Na;Yu, Shu-Ying;Hsueh, Po-Ren;Al-Hatmi, Abdullah M. S.;Meis, Jacques F.;Hagen, Ferry;Xiao, Meng;Wang, He;Barresi, Cinzia;Zhou, Meng-Lan;de Hoog, G. Sybren;Xu, Ying-Chun;
摘要
A total of 133 clinical Trichosporon isolates were collected in the National China Hospital Invasive Fungal Surveillance Net (CHIF-NET) program in 2009 to 2016. Accurate identification was performed by sequencing of the intergenic spacer 1 (IGS1) region. Among these isolates, Trichosporon asahii (108 isolates (81.2%]) was the leading species, followed by Trichosporon dermatis (7 isolates [5.3%]), Trichosporon asteroides (5 isolates [3.8%]), Trichosporon inkin (5 isolates [3.8%]), Trichosporon dohaerlse (3 isolates [2.3%]), and 1 isolate (0.7%) each of Trichosporon faecale, Trichosporon jirovecii, Trichosporon mucoides, Trichosporon coremiiforme, and Trichosporon montevideense. Both the Vitek mass spectrometry (MS) (bioMerieux, Marcy l'Etoile, France) and Bruker Biotyper MS (Bruker Daltonics GmbH, Germany) platforms gave high levels (>97.5%) of correct identification when the species were present in the database. The geometric mean (GM) of amphotericin B MICs for T. asahii was 2-fold higher than that for non asahii Trichosporon. High fluconazole MICs (>= 8 mu g/ml) were observed for 25% of T. asahii isolates (27/108 isolates) and 16% of non asahii Trichosporon (4/25 isolates) isolates. Itraconazole MICs were .=0.5 mu g/ml for 89.5% of the isolates. Voriconazole was the most potent antifungal agent in vitro, with a GM of 0.09 mu g/ml. Genotyping of the isolates using IGS1 sequence alignment revealed that genotype 1 was most common (41.7%), followed by genotype 4 (31.5%), genotype 3 (23.1%), genotype 5 (0.9%), genotype 6 (0.9%), and genotype 7 (1.8%). Our data on species distribution, genotypes, and antifungal susceptibilities may contribute to a better understanding of the epidemiology of invasive Trichosporon infections throughout China.
机翻摘要
暂无翻译结果,您可以尝试点击头部的翻译按钮。
关键词/主题词
China;Trichosporon;genotype;invasive infection;susceptibility;
若您需要申请原文,请登录。

最新评论

暂无评论。

登录后可以发表评论

意见反馈
返回顶部