Method of treating degenerative disorders of the nervous system 机翻标题: 暂无翻译,请尝试点击翻译按钮。

公开号/公开日
US2012093812 A1 2012-04-19 [US20120093812]US8569242 B2 2013-10-29 [US8569242] / 2012-04-192013-10-29
申请号/申请日
2011US-13337504 / 2011-12-27
发明人
AKASSOGLOU KATERINA;
申请人
UNIVERSITY OF CALIFORNIA SAN DIEGO;
主分类号
IPC分类号
A01N-037/18A61K-039/395C07K-016/00
摘要
(US8569242) The invention herein related to methods and compositions for treating nervous system disorders.  The methods comprise administration of antibodies directed towards peptides that bind to receptors important in disease progression, thus attenuating the disease.
机翻摘要
暂无翻译结果,您可以尝试点击头部的翻译按钮。
地址
代理人
代理机构
;
优先权号
2005US-60720218 2005-09-23 2006WO-US37211 2006-09-25 2008US-12067792 2008-03-21 2010US-12896410 2010-10-01 2011US-13337504 2011-12-27
主权利要求
(US8569242) What is claimed is: 1.  A method for the treatment of a degenerative disorder of the nervous system comprising administering to a subject in need an effective amount of a composition comprising a pharmaceutically acceptable excipient and an antibody that binds a peptide consisting of an amino acid sequence at least 89% identical to SEQ ID NO: 1, wherein said antibody inhibits fibrin gamma 377-395 (SEQ ID NO:1) specific binding to Mac-1, wherein the degenerative disorder of the nervous system involves leakage of fibrinogen perivascularly in the brain. 2. The method of claim 1, wherein the antibody is a monoclonal antibody. 3. The method of claim 1, wherein the antibody is an antigen-binding fragment selected from the group consisting of Fab, Fab', F(ab')2 and F(v). 4. The method of claim 1, wherein the antibody is chimeric. 5. The method of claim 1, wherein the antibody is humanized. 6. The method of claim 1, wherein the degenerative disorder of the nervous system is selected from the group consisting of multiple sclerosis, spinal cord injury, stroke and Alzheimer's Disease. 7. The method of claim 1, wherein the amino acid sequence is at least 94% identical to SEQ ID NO:1. 8. The method of claim 1, wherein the amino acid sequence is shown in SEQ ID NO:1. 9. The method of claim 1, wherein the antibody is a human antibody.
法律状态
(US8569242) LEGAL DETAILS FOR US2012093812  Actual or expected expiration date=2026-09-25    Legal state=ALIVE    Status=GRANTED     Event publication date=2011-12-27  Event code=US/APP  Event indicator=Pos  Event type=Examination events  Application details  Application country=US US13337504  Application date=2011-12-27  Standardized application number=2011US-13337504     Event publication date=2011-12-27  Event code=US/EXMR  Event type=Administrative notifications  USPTO Examiner Name Primary Examiner: CHERNYSHEV, OLGA N    Event publication date=2011-12-27  Event code=US/ART  Event type=Administrative notifications  USPTO Art Group  ART=1649     Event publication date=2011-12-27  Event code=US/ENT  Event type=Administrative notifications  Entity Status Set to Undiscounted Business Entity Status: UNDISCOUNTED    Event publication date=2011-12-27  Event code=US/AIA  Event type=Administrative notifications  First Inventor File Indicated:  AIA=No     Event publication date=2011-12-27  Event code=US/DK  Event type=Examination events  Attorney Docket Number Docket Nbr: 24978-0120    Event publication date=2011-12-27  Event code=US/CUST  Event type=Examination events  Attorney/Agent Customer Number Customer Nbr: 29052    Event publication date=2011-12-27  Event code=US/DISCSEF  Event type=OAI  Electronic Information Disclosure Statement    Event publication date=2011-12-27  Event code=US/IDS  Event type=Examination events  Event type=OAI  Information Disclosure Statement Filed    Event publication date=2012-01-11  Event code=US/POAC  Event type=Change of name or address  Change in Power of Attorney (May Include Associate POA)    Event publication date=2012-01-11  Event code=US/APPFILEREC  Event type=Administrative notifications  Event type=OAO  Filing Receipt    Event publication date=2012-01-20  Event code=US/DOCK  Event indicator=Pos  Event type=Examination events  Case Docketed to Examiner    Event publication date=2012-04-19  Event code=US/A1  Event type=Examination events  Application published  Publication country=US  Publication number=US2012093812  Publication stage Code=A1  Publication date=2012-04-19  Standardized publication number=US20120093812     Event publication date=2012-04-19  Event code=US/PGPUBN  Event indicator=Pos  Event type=Examination events  Event type=OAO  PG-Pub Issue Notification    Event publication date=2012-07-13  Event code=US/AS  Event type=Change of name or address  Event type=Reassignment  Assignment Owner: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF  Effective date of the event=2012-07-02  CONFIRMATORY LICENSE ASSIGNOR:UNIVERSITY OF CALIFORNIA SAN DIEGO REEL/FRAME:028553/0768     Event publication date=2013-01-16  Event code=US/CTNF  Event type=Examination events  Event type=OA  Event type=OAO  Non-Final Rejection    Event publication date=2013-04-05  Event code=US/CTNFR  Event type=Examination events  Event type=OAI  Response after Non-Final Action    Event publication date=2013-05-07  Event code=US/CTFR  Event type=Examination events  Event type=OA  Event type=OAO  Final Rejection    Event publication date=2013-06-18  Event code=US/INVSUM  Event type=Examination events  Event type=OAI  Event type=INT  Interview Summary- Applicant Initiated    Event publication date=2013-06-18  Event code=US/INVSUM  Event type=Examination events  Event type=OAI  Event type=INT  Interview Summary- Applicant Initiated    Event publication date=2013-07-01  Event code=US/CTFAR  Event type=Examination events  Event type=OAI  Response after Final Action    Event publication date=2013-07-09  Event code=US/NOAM  Event indicator=Pos  Event type=Examination events  Event type=OAO  Mail Notice of Allowance    Event publication date=2013-07-09  Event code=US/DOCK  Event indicator=Pos  Event type=Examination events  Case Docketed to Examiner    Event publication date=2013-07-30  Event code=US/ENT  Event type=Administrative notifications  Entity Status Set to Undiscounted    Event publication date=2013-09-28  Event code=US/APRDY  Event indicator=Pos  Event type=Examination events  Application Is Considered Ready for Issue    Event publication date=2013-10-09  Event code=US/PAT  Event indicator=Pos  Event type=Event indicating In Force  Patented Case    Event publication date=2013-10-09  Event code=US/ISSM  Event indicator=Pos  Event type=Examination events  Event type=OAO  Event type=Restitution or restoration  Issue Notification Mailed    Event publication date=2013-10-29  Event code=US/B2  Event indicator=Pos  Event type=Event indicating In Force  Granted patent as second publication  Publication country=US  Publication number=US8569242  Publication stage Code=B2  Publication date=2013-10-29  Standardized publication number=US8569242     Event publication date=2013-10-29  Event code=US/354  Event indicator=Pos  Event type=Extension of term of duration of protection  Patent term extended under  35 U.S.C 154(b) until/for Delays (A,B,C): 0  Overlap Delays: 0  Non Overlap Delays: 0   PTO Office Delays: 0  Applicant Delays: 0  Adjustment total:  Number of days of extension=0    Event publication date=2013-12-10  Event code=US/CC  Event type=Corrections  Event type=Restitution or restoration  Certificate of Correction - Post Issue Communication    Event publication date=2013-12-16  Event code=US/AS  Event type=Change of name or address  Event type=Reassignment  Assignment Owner: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF  Effective date of the event=2013-11-19  CONFIRMATORY LICENSE ASSIGNOR:UNIVERSITY OF CALIFORNIA SAN DIEGO REEL/FRAME:031820/0254     Event publication date=2016-11-08  Event code=US/NMFP  Event type=Payment or non-payment notifications  Publication of First Notice of Maintenance Fees Payable. PAYMENT NOTICE YEAR:  Year of payment of annual fees=3     Event publication date=2017-05-01  Event code=US/FPAY  Event indicator=Pos  Event type=Event indicating In Force  Event type=Payment or non-payment notifications  Fee payment recorded   Annual fees payment date=2017-05-01     Year of payment of annual fees=4
专利类型码
A1B2
国别省市代码
若您需要申请原文,请登录。

最新评论

暂无评论。

登录后可以发表评论

意见反馈
返回顶部