(EP2756757) Preparation and compositions of zero-valent sulphur having high bioavailability, and uses thereof 机翻标题: 暂无翻译,请尝试点击翻译按钮。

源语言标题
(EP2756757) Preparation and compositions of zero-valent sulphur having high bioavailability, and uses thereof
公开号/公开日
EP2756757EP2756757EP2756757 / 2019-04-242015-05-202014-07-23
申请号/申请日
EP12840653 / 2012-09-13
发明人
GOJON ROMANILLOS GABRIELGOJÓN ZORRILLA GABRIEL;
申请人
NUEVAS ALTERNATIVAS NATURALES;
主分类号
IPC分类号
A61K-033/04 A61K-033/06 A61K-045/06 A61P-039/00
摘要
(EP2756757) The present invention features sulfur-rich compositions and preparations thereof that are safe and effective as hydrogen sulfide prodrugs of high bioavailability. The invention also includes methods of treating pathological conditions associated with oxidative stress using sulfur-rich compositions. The invention further includes sulfur-rich compositions as antidotes and medical food for preserving and promoting general health.
机翻摘要
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地址
代理人
(EP2756757) Carpmaels & Ransford LLP ([GB]) Reg. Nb: 101299776
代理机构
;
优先权号
2011US-61534585 2012WO-MX00086
主权利要求
(EP2756757) 1. A composition comprising 90-99.9% (w/w) elemental alpha sulfur and 0.01-10% (w/w) highly polar components, and optionally comprising one or more pharmaceutically acceptable excipients, wherein said highly polar components are selected from the group consisting of sodium polythionate, potassium polythionate, ammonium polythionate, calcium polythionate, polythionic acids, sodium thiosulfate, potassium thiosulfate, ammonium thiosulfate, calcium thiosulfate, sodium sulfate, potassium sulfate, and ammonium sulfate, wherein the composition comprises at least 96% bioactive zerovalent sulfur that readily undergoes bioconversion into hydrogen sulfide. 2. The composition of claim 1, wherein said highly polar components are selected from sodium sulfate, sodium polythionate, and sodium thiosulfate. 3. A composition comprising an elemental alpha sulfur and one or more highly polar components in a ratio from 10 to 150 parts elemental alpha sulfur to 1 part highly polar components (w/w) for enteral, topical, or parenteral administration, wherein said highly polar components are selected from the group consisting of sodium polythionate, potassium polythionate, ammonium polythionate, calcium polythionate, polythionic acids, sodium thiosulfate, potassium thiosulfate, ammonium thiosulfate, calcium thiosulfate, sodium sulfate, potassium sulfate, and ammonium sulfate, wherein the composition comprises at least 96% bioactive zerovalent sulfur that readily undergoes bioconversion into hydrogen sulfide. 4. The composition of claim 3, wherein said composition is formulated for enteral administration and said elemental alpha sulfur and said highly polar components are present together in an amount of 400 mg. 5. The composition of claim 4, wherein said composition is a capsule. 6. The composition of claim 3, further comprising a third agent. 7. The composition of claim 6 wherein said third agent is a cardiovascular disease drug, an antiinflammatory drug, an anti-neurodegenerative drug, or an anticancer/anti-proliferative drug or wherein said elemental alpha sulfur, said highly polar components, and said third agent are present in an effective amount to treat a condition associated with oxidative stress. 8. The composition of claim 6, wherein said third agent is a dietary supplement or wherein said elemental alpha sulfur, said highly polar components, and said third agent are present in an effective amount to promote or maintain general health.
法律状态
GRANTED
专利类型码
B1A4A1
国别省市代码
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