Fungus-specific imaging agents 机翻标题: 暂无翻译,请尝试点击翻译按钮。

公开号/公开日
WO2007134229 A2 2007-11-22 [WO2007134229]WO2007134229 A3 2008-10-02 [WO2007134229] / 2007-11-222008-10-02
申请号/申请日
2007WO-US68766 / 2007-05-11
发明人
LI CHUN;KONTOYIANNIS DIMITRIOS P;
申请人
UNIVERSITY OF TEXAS;
主分类号
IPC分类号
A01N-037/18A61K-038/00
摘要
(WO2007134229) The disclosure relates to an imaging composition including a fungus-specific peptide and an imaging material.  Another imaging composition includes a fungus-specific peptide and a chelator able to chelate a radionuclide.  The disclosure also provides to a method of detecting a fungal infection.  The method includes administering an imaging agent to a patient.  The imaging agent comprises a fungus-specific peptide and an imaging material.  Then one may detect the imaging agent in the patient.  Detecting retained imaging agent in a tissue or organ indicates fungal infection of the tissue or organ.
机翻摘要
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地址
代理人
代理机构
;
优先权号
2006US-60747044 2006-05-11
主权利要求
(WO2007134229) 1. CLAIMS 1. An imaging composition comprising: a fungus-specific peptide comprising at least a portion having the sequence of CGGRLGPFC (SEQ. ID. NO: 1) or CWGHSRDEC (SEQ . ID .NO: 2) ; and an imaging material . 2. A composition according to Claim 1, wherein the peptide comprises cyclic CGGRLGPFC (SEQ. ID. NO: 1) or cyclic CWGHSRDEC (SEQ. ID. NO: 2) . 3. A composition according to Claim 1, wherein the imaging material comprises a radionuclide. 4. A composition according to Claim 1, further comprising a chelator. 5. A composition according to Claim 1, further comprising a linker molecule. 6. A composition according to Claim 1, further comprising a polymer. 7. A composition according to Claim 1, further comprising a therapeutic agent. 8. A composition according to Claim 1, further comprising aminobenzyl-DTPA and succinic acid, and wherein the peptide comprises cyclic CGGRLGPFC (SEQ. ID.NO: 1) and the imaging material comprises111In. 9. A composition according to Claim 1, wherein the wherein the peptide comprises cyclic CGGRLGPFC (SEQ. ID. NO: 1) and the imaging material comprises68Ga, further comprising DOTA. 10. An imaging composition comprising: a fungus-specific peptide comprising at least a portion having the sequence of CGGRLGPFC (SEQ. ID. NO: 1) or CWGHSRDEC (SEQ . ID . NO : 2 ) ; and a chelator able to chelate a radionuclide. 11. A composition according to Claim 10, wherein the peptide comprises cyclic CGGRLGPFC (SEQ. ID. NO: 1) or cyclic CWGHSRDEC (SEQ . ID .NO : 2) . 12. A composition according to Claim 10, further comprising a linker molecule. 13. A composition according to Claim 10, further comprising a polymer. 14. A composition according to Claim 10, further comprising a therapeutic agent. 15. A composition according to Claim 10, wherein the peptide comprises cyclic CGGRLGPFC (SEQ. ID. NO: 1) the chelator comprises aminobenzyl-DTPA, and the radionuclide comprises111In, further comprising succinic acid. 16. A composition according to Claim 10, wherein the wherein the peptide comprises cyclic CGGRLGPFC (SEQ. ID.NO:1) , the chelator comprises DOTA, and the imaging material comprises68Ga. 17. A method of detecting a fungal infection comprising: administering an imaging agent to a patient, wherein the imaging agent comprises a fungus-specific peptide comprising at least a portion having the sequence of CGGRLGPFC (SEQ . ID . NO: 1) or CWGHSRDEC (SEQ . ID .NO : 2) and an imaging material; and detecting the imaging agent in the patient, wherein detecting retained imaging agent in a tissue or organ indicates fungal infection of the tissue or organ. 18. A method according to Claim 17, wherein the infection is an Aspergillus or Rhizopus infection. 19. A method according to Claim 17, wherein the infection is in a lung of the patient. 20. A method according to Claim 17, wherein detection includes gamma scintography or μ-PET.
法律状态
(WO2007134229) LEGAL DETAILS FOR WO2007134229  Actual or expected expiration date=2009-11-11    Legal state=DEAD    Status=LAPSED     Event publication date=2007-05-11  Event code=WO/APP  Event indicator=Pos  Event type=Examination events  Application details  Application country=WO WOUS2007068766  Application date=2007-05-11  Standardized application number=2007WO-US68766     Event publication date=2007-11-22  Event code=WO/A2  Event type=Examination events  International application published without international search report  Publication country=WO  Publication number=WO2007134229  Publication stage Code=A2  Publication date=2007-11-22  Standardized publication number=WO2007134229     Event publication date=2008-10-02  Event code=WO/A3  Event indicator=Pos  Event type=Examination events  Later publication of ISR with revised front page  Publication country=WO  Publication number=WO2007134229  Publication stage Code=A3  Publication date=2008-10-02  Standardized publication number=WO2007134229     Event publication date=2009-11-11  Event code=WO/EETL  Event type=Event indicating Not In Force  PCT Application validity period expired. LEGAL DETAILS FOR DESIGNATED STATE DE  Actual or expected expiration date=2008-11-12    Legal state=DEAD    Status=LAPSED   Corresponding cc:  Designated or member state=DE     Event publication date=2008-11-12  Event code=WO/NENP  Event type=Event indicating Not In Force  Non-entry into the national phase in: Corresponding cc:  Designated or member state=DE  LEGAL DETAILS FOR DESIGNATED STATE US2010034739  Actual or expected expiration date=2011-05-10    Legal state=DEAD    Status=LAPSED   Corresponding cc:  Designated or member state=US Corresponding appl: US22715507  Application date in the designated or member state=2007-05-11   Application number in the designated or member state=2007US-12227155 Corresponding cc:  Designated or member state=US Corresponding pat: US2010034739  Publication stage code in the designated or member state=A1  Publication date in the designated or member state=2010-02-11   Publication number in the designated or member state=US20100034739    Event publication date=2008-11-07  Event code=WO/WWE  Event indicator=Pos  Event type=Entry into national phase  Wipo information: entry into national phase Corresponding cc:  Designated or member state=US     Event publication date=2011-05-10  Event code=US/STCHG  Patent Status changed by the national office Corresponding cc:  Designated or member state=US
专利类型码
A2A3
国别省市代码
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