Pharmaceutical Composition Containing Glimepiride and Metformin Hydrochloride 机翻标题: 暂无翻译,请尝试点击翻译按钮。

公开号/公开日
US2016051511 A1 2016-02-25 [US20160051511] / 2016-02-25
申请号/申请日
2015US-14727396 / 2015-06-01
发明人
LARA OCHOA JOSÉ MANUEL FRANCISCO;
申请人
SILANES;
主分类号
IPC分类号
A61K-031/155A61K-031/40A61K-031/64A61P-003/10C07C-303/40C07C-311/59C07D-207/26C07D-207/277C07D-241/24
摘要
(US20160051511) Pharmaceutical compositions of the active substances glimepiride with metformin or its salts such as hydrochloride, succinate, fumarate, etc. are useful to control blood glucose in patients with type 2 diabetes.  To prove the effectiveness of the combination, clinical studies were conducted that demonstrated the existence of not only an additive effect, but also a synergistic effect of the two drugs compared with monotherapy using only one of the drugs used in combination.  In consequence, the combination may be used as an effective and safe therapy to control blood glucose in patients with type 2 diabetes, using different proportions of the active substances in combinations suitable for the needs of different patients.
机翻摘要
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地址
代理人
代理机构
;
优先权号
2002WO-MX00003 2002-01-25 2005US-10502403 2005-06-20 2015US-14727396 2015-06-01
主权利要求
(US20160051511) 1-11. (canceled) 12. A solid pharmaceutical composition, comprising a synergistic combination of glimepiride and metformin hydrochloride, wherein the weight ratio of glimepiride and metformin hydrochloride is about 1/250, wherein the combination of glimepiride and metformin hydrochloride reduces blood glucose levels in a patient with type 2 diabetes greater than either glimepiride or metformin hydrochloride alone, and wherein the composition further comprises 18 mg to 36 mg of povidone, 3 mg to 6 mg of magnesium stearate, and 1.8 mg to 3.6 mg of colloidal silicon dioxide.
法律状态
(US20160051511) LEGAL DETAILS FOR US2016051511  Actual or expected expiration date=2016-06-07    Legal state=DEAD    Status=LAPSED     Event publication date=2015-06-01  Event code=US/APP  Event indicator=Pos  Event type=Examination events  Application details  Application country=US US14727396  Application date=2015-06-01  Standardized application number=2015US-14727396     Event publication date=2015-06-01  Event code=US/EXMR  Event type=Administrative notifications  USPTO Examiner Name Primary Examiner: LOVE, TREVOR M    Event publication date=2015-06-01  Event code=US/ART  Event type=Administrative notifications  USPTO Art Group  ART=1611     Event publication date=2015-06-01  Event code=US/DK  Event type=Examination events  Attorney Docket Number Docket Nbr: 2099.0090001/PAJ/LMB Customer Nbr: 26111    Event publication date=2015-06-01  Event code=US/ENT  Event type=Administrative notifications  Business Entity Status: UNDISCOUNTED    Event publication date=2015-06-01  Event code=US/AIA  Event type=Administrative notifications  First Inventor File Indicated:  AIA=No     Event publication date=2015-06-01  Event code=US/ENTYSTA  Event type=Administrative notifications  Entity Status Set to Undiscounted    Event publication date=2015-06-10  Event code=US/APPINC  Event type=Examination events  Event type=OAO  Notice Mailed--Application Incomplete--Filing Date Assigned    Event publication date=2015-06-10  Event code=US/APPFILEREC  Event type=Administrative notifications  Event type=OAO  Filing Receipt    Event publication date=2015-10-05  Event code=US/AS  Event type=Change of name or address  Event type=Reassignment  Assignment Owner: SILANES S.A. DE C.V., MEXICO  Effective date of the event=2005-06-03  ASSIGNMENT OF ASSIGNORS INTEREST ASSIGNOR:LARA OCHOA, JOSE MANUEL FRANCISCO REEL/FRAME:036729/0943     Event publication date=2015-10-05  Event code=US/AS  Event type=Change of name or address  Event type=Reassignment  Assignment  Effective date of the event=2005-06-03  ASSIGNMENT OF ASSIGNORS INTEREST ASSIGNOR:LARA OCHOA, JOSE MANUEL FRANCISCO REEL/FRAME:036729/0943     Event publication date=2015-11-10  Event code=US/IDS  Event type=Examination events  Event type=OAI  Information Disclosure Statement Filed    Event publication date=2015-11-10  Event code=US/PTARDY  Event indicator=Pos  Event type=Examination events  Patent Term Adjustment - Ready for Examination    Event publication date=2015-11-16  Event code=US/DOCK  Event indicator=Pos  Event type=Examination events  Case Docketed to Examiner in GAU    Event publication date=2015-11-16  Event code=US/RECEIPTUP  Event type=Administrative notifications  Event type=OAO  Filing Receipt - Updated    Event publication date=2015-12-02  Event code=US/CTNF  Event type=Examination events  Event type=OA  Event type=OAO  Non-Final Rejection    Event publication date=2016-02-25  Event code=US/A1  Event type=Examination events  Application published  Publication country=US  Publication number=US2016051511  Publication stage Code=A1  Publication date=2016-02-25  Standardized publication number=US20160051511     Event publication date=2016-02-25  Event code=US/PGPUBN  Event indicator=Pos  Event type=Examination events  Event type=OAO  PG-Pub Issue Notification    Event publication date=2016-06-07  Event code=US/ABNOA  Event indicator=Neg  Event type=Event indicating Not In Force  Event type=OAO  Abandoned -- Failure to Respond to an Office Action
专利类型码
A1
国别省市代码
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