Chimeric neuregulins and method of making and use thereof 机翻标题: 暂无翻译,请尝试点击翻译按钮。

公开号/公开日
US2015183844 A1 2015-07-02 [US20150183844] / 2015-07-02
申请号/申请日
2015US-14594821 / 2015-01-12
发明人
FORD BYRON D;
申请人
BRAIN GEN BIOTECH;
主分类号
IPC分类号
A61K-038/18A61K-038/48A61K-045/06A61K-047/48C07K-014/475
摘要
(US20150183844) Composition containing a chimeric neuregulin polypeptides and method of making such polypeptides are disclosed.  The chimeric neuregulin comprises a first moiety of at least 10 amino acids, wherein the first moiety is derived from a first polypeptide; and a second moiety of at least 5 amino acids, wherein the second moiety is derived from a second polypeptide; wherein the first polypeptide is a neuregulin and the chimeric neuregulin exhibits an enhanced binding affinity to integrin, Erb 3, or Erb 4 comparing to that of the first neuregulin.
机翻摘要
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地址
代理人
代理机构
;
优先权号
2012US-13627555 2012-09-26 2013US-13865812 2013-04-18 2015US-14594821 2015-01-12
主权利要求
(US20150183844) 1. A chimeric neuregulin polypeptide having an integrin domain that binds to an integrin and an Erb3/4 binding domain that binds to Erb3 and/or Erb4, said chimeric neuregulin polypeptide comprising: a neuregulin backbone derived from a native neuregulin polypeptide; and a donor fragment of at least one aminoacid, wherein said donor fragment (1) replaces a target fragment in said native neuregulin polypeptide, wherein said donor fragment differs from said target fragment by at least one aminoacid, or (2) is inserted into an insertion site of said neuregulin polypeptide; and wherein said donor fragment forms at least a portion of said integrin binding domain and/or at least a portion of said Erb3/4 binding domain of said chimeric neuregulin polypeptide. 11. A chimeric neuregulin, comprising: a first moiety of at least 10 amino acids, wherein said first moiety is derived from a first polypeptide; and a second moiety of at least 5 amino acids, wherein said second moiety is derived from a second polypeptide; wherein said first polypeptide is a first neuregulin, and wherein said chimeric neuregulin exhibits an enhanced binding affinity to integrin, Erb 3, or Erb 4 comparing to that of said first neuregulin.
法律状态
(US20150183844) LEGAL DETAILS FOR US2015183844  Actual or expected expiration date=2032-09-26    Legal state=ALIVE    Status=PENDING     Event publication date=2015-01-12  Event code=US/APP  Event indicator=Pos  Event type=Examination events  Application details  Application country=US US14594821  Application date=2015-01-12  Standardized application number=2015US-14594821     Event publication date=2015-01-12  Event code=US/EXMR  Event type=Administrative notifications  USPTO Examiner Name Primary Examiner: FONTAINHAS, AURORA M    Event publication date=2015-01-12  Event code=US/ART  Event type=Administrative notifications  USPTO Art Group  ART=1649     Event publication date=2015-01-12  Event code=US/DK  Event type=Examination events  Attorney Docket Number Docket Nbr: 1074-023 CONT Customer Nbr: 38598    Event publication date=2015-01-12  Event code=US/ENT  Event type=Administrative notifications  Business Entity Status: SMALL    Event publication date=2015-01-12  Event code=US/AIA  Event type=Administrative notifications  First Inventor File Indicated:  AIA=No     Event publication date=2015-01-12  Event code=US/ENTYSTA  Event type=Administrative notifications  Entity Status Set to Undiscounted    Event publication date=2015-01-14  Event code=US/SMALL  Event type=Administrative notifications  Appl Has Filed a Verified Statement of Micro to Small Entity Status    Event publication date=2015-01-21  Event code=US/APPFILEREC  Event type=Administrative notifications  Event type=OAO  Filing Receipt    Event publication date=2015-01-21  Event code=US/APPINC  Event type=Examination events  Event type=OAO  Notice Mailed--Application Incomplete--Filing Date Assigned    Event publication date=2015-03-20  Event code=US/AS  Event type=Change of name or address  Event type=Reassignment  Assignment Owner: BRAIN-GEN BIOTECH, GEORGIA  Effective date of the event=2015-03-19  ASSIGNMENT OF ASSIGNORS INTEREST ASSIGNOR:FORD, BYRON D. REEL/FRAME:035212/0412     Event publication date=2015-03-20  Event code=US/PTARDY  Event indicator=Pos  Event type=Examination events  Patent Term Adjustment - Ready for Examination    Event publication date=2015-03-24  Event code=US/IDS  Event type=Examination events  Event type=OAI  Information Disclosure Statement Filed    Event publication date=2015-03-27  Event code=US/RECEIPTUP  Event type=Administrative notifications  Event type=OAO  Filing Receipt - Updated    Event publication date=2015-04-01  Event code=US/DOCK  Event indicator=Pos  Event type=Examination events  Case Docketed to Examiner in GAU    Event publication date=2015-07-02  Event code=US/A1  Event type=Examination events  Application published  Publication country=US  Publication number=US2015183844  Publication stage Code=A1  Publication date=2015-07-02  Standardized publication number=US20150183844     Event publication date=2015-07-02  Event code=US/PGPUBN  Event indicator=Pos  Event type=Examination events  Event type=OAO  PG-Pub Issue Notification    Event publication date=2016-06-09  Event code=US/CTNF  Event type=Examination events  Event type=OA  Event type=OAO  Non-Final Rejection    Event publication date=2016-10-28  Event code=US/CTFR  Event type=Examination events  Event type=OA  Event type=OAO  Final Rejection    Event publication date=2017-01-24  Event code=US/RCEX  Event type=Examination events  Event type=RCE  Event type=OAI  Request for Continued Examination (RCE)    Event publication date=2017-01-26  Event code=US/DRCECAP  Event type=RCE  Event type=OAO  Disposal for a RCE / CPA / R129    Event publication date=2017-08-03  Event code=US/EXAC  Event type=Examination events  Event type=OAO  Examiner's Amendment Communication    Event publication date=2017-08-16  Event code=US/NOAM  Event indicator=Pos  Event type=Examination events  Event type=OAO  Mail Notice of Allowance
专利类型码
A1
国别省市代码
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