Process for preparation of 2- (2-benzoila substituted) - 4- (oxi-substituted or uncle-substituted) - 1,3-ciclohexanodionas. 机翻标题: 暂无翻译,请尝试点击翻译按钮。

源语言标题
(BRPI8705524) Processo para preparação de 2-(2-benzoíla substituída)-4-(oxi-substituído ou tio-substituído)-1,3-ciclohexanodionas.
公开号/公开日
BR8705524 A 1988-05-24 [BR8705524]BRPI8705524 A1 1992-11-24 [BRPI8705524]BRPI8705524 B1 2018-03-20 [BRPI8705524] / 1988-05-241992-11-242018-03-20
申请号/申请日
1987BR-0005524 / 1987-10-15
发明人
LEE DAVID LOUIS;
申请人
STAUFFER CHEMICAL;
主分类号
IPC分类号
A01N-031/06A01N-035/06A01N-037/08A01N-037/22A01N-037/24A01N-037/34A01N-037/42A01N-041/06A01N-041/10A01N-047/02C07C-045/00C07C-045/54C07C-049/76C07C-067/00C07C-069/76C07C-069/92C07C-201/00C07C-205/45C07C-205/57C07C-213/00C07C-225/22C07C-229/54C07C-233/15C07C-233/33C07C-233/41C07C-233/43C07C-233/54C07C-253/00C07C-255/56C07C-311/15C07C-311/19C07C-313/00C07C-317/00C07C-317/14C07C-317/20C07C-317/24C07C-317/30C07C-317/36C07C-317/38C07C-317/44C07C-317/46C07C-317/48C07C-317/50C07C-323/03C07C-323/17C07C-323/22C07C-323/62C07C-323/65
摘要
(BRPI8705524) Compounds of the formula <CHEM> wherein X is oxy, thio, sulfinyl or sulfonyl; R is halogen; C1-C2 alkyl; C1-C2 alkoxy; trifluoromethoxy; difluoromethoxy; nitro; cyano; C1-C2 haloalkyl; R<a>SOn- wherein n is 0 or 2 and R<a> is C1-C2 alkyl, trifluoromethyl or difluoromethyl; R<1> is hydrogen, C1-C4 alkyl, phenyl or substituted phenyl; R<2> is hydrogen or C1-C4 alkyl; or R<1> and R<2> together are C2-C5 alkylene; R<3> is hydrogen, C1-C4 alkyl, phenyl or substituted phenyl with the proviso that R<1> and R<3> are not both phenyl or substituted phenyl; R<4> is hydrogen or C1-C4 alkyl; R<5> is hydrogen or C1-C4 alkyl; R<6> is hydrogen, C1-C4 alkyl, C1-C4 haloalkyl, or phenyl; R<7> and R<8> independently are (1) hydrogen; (2) halogen; (3) C1-C4 alkyl; (4) C1-C4 alkoxy; (5) trifluoromethoxy; (6) cyano; (7) nitro; (8) C1-C4 haloalkyl; (9) R<b>SOn- wherein n is the integer 0, 1 or 2; and R<b> is (a) C1-C4 alkyl; (b) C1-C4 alkyl substituted with halogen or cyano; (c) phenyl; or (d) benzyl; (10) -NR<c>R<d> wherein R<c> and R<d> independently are hydrogen or C1-C4 alkyl; (11) R<e>C(O)- wherein R<e> is C1-C4 alkyl or C1-C4 alkoxy; or (12) -SO2NR<c>R<d> wherein R<c> and R<d> are as defined; and (13) -N(R<c>)C(O)R<d> wherein R<c> and R<d> are as defined; and their salts.  (From EP0268795 A2)
机翻摘要
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地址
代理人
代理机构
;
优先权号
1986US-06919280 1986-10-16 1987US-07086268 1987-08-20
主权利要求
(BR8705524)  9. - -I al 41 44. - II if 04 in eisee P. EIVINDICA}COES 1. Process for composite preparation, dea formula 1. 0 where X is Oxi, uncle, sulfinila or sulfonila; R is halogenio; alquila in C 1 -0 2;  alceai in 0 1 - C 2; trifluormethi; difluormetOxi; nitro; cyan; haloalquila in C 1 -0 2; R If the n - that n the 0 or 2 and R it is alquila C 1 -0 2, trifluormetila or difluor =atila; R 1 is hydrogen; alquila C i - C 41 fe nila or fenila substituted; Cm R 2 is hydrogen or alquila C1-C4; 6. 48 8 60 GE 6899 stamps le, 19 e. e.e 0 of fi D Of and -I eme ID e  . e and Me to and the 864. 1 G Of 41. R 1 and R2 sao jointly alauile in C 2 - 3 C R the hidrogenia alquila C 1 - the 4 ' fenila or fenila substituted, on condition that 5. 1 n eRnao are both femila or fenila substituted; R4 and hydrogen or alquila 0 1 -0 4; R 5 is hidrogenia or alquila 0 1 -0 4;  . the R6 and hydrogen, alquila C1- 0 4, haloalquila 0 1 - C 4 or fenila; R? e R 8 is independently (1) hydrogen; (2) halogenio; (3) alquila 0 1 -0 4; (4) al &5: d.01 - C 4 ' (5) trifluormettai; (6) cial2P; ()nitro;  (8) haloalquila in C 1 -0 4; (972 b If n - where n and the whole number, 1 or 2; e R b the (a) alquila 0 1 -0 4;  (b) alquila 0 1 -0 4 substituted by halogenio or eiano; (c) f enila; or (d) benzila; (10) - NR and R d that R c and R d is independently hidrogenia or alquila C i - C 4;  (11) R and C (0) - where R and alquila in 0 1 0 4 or alceai in C1 - C 4 ' or (12) -80 2 NR and R d where R and R d co is such me if defined; e (13) - U (R e) C (0) R d where 11 c and R d as is defined, the process being characterized pe lo fact of that it understands:  a) reacting diona with the formula  - 3 00 GIN GE CM.deg. COO ID of the 41 la EP 91. ,8. el and di ellee where R 1 6 R and X as are defined, with one rea people of benzoila substituted dea formula where R, R? e R 8 as is defined and Y is haloge nio, alquila - C (0) - C-C 1 - C 4, alcoxi - C (0) - 0-C 1 - 4 C or R.? - c-c ()) Y where R, 7 R and R 8 in this dea part cos molecule are idinti to those in the reagent shown above with for me 904. Co rn HOLLOW Blind person CO ID Calo&, M5 El CI fodi Me OMPOO 19. - 19 0011. COO go - Dethe in the one mol of a moderate base to form an intermediate ester enol dea formula 3. went et that R 8 R and X as is defined, and the stage (b) reaction of one mol deo to be enol intermediate with - 1 the 4 soft ones of a moderate base, and of 0,01 mol "about 0,5 moi or more than to a Zante of cianeto forming a dea compound formula 1. 5 where moderate base and R 8 R and X are in agreement of Clinked above. 2. Process for composite preparation, in accordance with claim 1, characterized for the fact of that X the halogenio, the base moderates dea trialquilamina 0 1 -0 61 piridina, carbonate me DG G GOGO  G@ ema @G @CO GDOM Olhe Glien @CG Gen G@ DOM such alkaline or fosfato of alkaline metal and the source of cianeto of alkaline metal, cianohidrinas of alquil metila O1-C4 ketones, cianohidrinas of benzaldeidn or aldehydes alifaticos-2 C 5 ' cianohidrinas, to ciar. 5. zinc grandson, cyanates of tri (alquila inferior) silila or cianeto of hydrogen. 3. Process for composite preparation, in accordance with claim 2, characterized for the fact of that X chlorine, trialquilamina the moderate base o 10. 0 1 - C 6, piridina, carbonate of aio or fosfato of sodium and the source of cianeto cianeto of potassium, cianohidrina of acetone or cianeto of hydrogen. 111. GO, 61 Une co - mia and Me II acts noa RE= DEA INVENZa0 Pioneer patent of "PROCESS Para RA PTLEPARA}C AND R ZC OF OC STC S". Composites of f6rmula  - ^ 7 ) (S. -4 \ \ r - 1. 0 where x is Oxi, uncle, sulfinila or sulfori went; R and halosecio; alquila in C 1 -0 2;  alocizi in C l - C 2; trifluor=et6xi; dinuormet&d; nitro; pipe; halcgencalquila in 0 1 -0 2; R the SO, - it was that n C or 2 and R it is alquila en 0 1 - C 22 trifluormetilaou difluor=etila; P the hid-NREN. - alquila .deg.2 C. - C fenila or fenila substituted;  - 2 - to . the ring 0,0 pe IS Me R' the hidrogenia cu alquila in C l - Ch; or pl and R c are jointly alquile in en C - 3 Cr- 2. 2 ' 2. the hydrogen, alquila in C l - C, fenila cu fenila substitul.de, on condition that R - and 1,1, - "are not both fenila or fenila substitdda; R4 R 6 hidrogenia or alquila in 1 - 6 4. C" R 5 hidrogenia or alauila in 0 C. - R and the hidrogenia alquila in C i - C, halogenoalquila.em - C 1 -0 4.ou fenila;  e R - I sweat (1) hidrogenia independently; (2) halogenio; (5) alquila in C i - C 4; (4) alcomi in 0 1 -0 4; (5) trifluormetomi; (6) top of a mountain; (7) nitro; (s) halogencalquila in C 7 - C h; (9) R b aC n - where n to namero entire, 1 or 2; e R b 6 (a) alqui la in C l - C 4; (b) alquila en C l - C 4 substituted to per ha logenio or cirno; (c) fenila; or (d) benzila; (10)  - NR c R d where and d they are independently hidrogenia or alquila e= C 1 -0 4; (11) R and C (C) - where R and 6 ai quits in C i - C cu alcomi in C i - C 4; or (12) - SC 2 NR c R d where and .deg. and R d they are such eats if it defined; e (15) - Net () C (C) R d where R c and R d is as if defined;  its you leave. 11606. 41 66 G6 OGG4 GO G 499. 6 6 540. 5 32 4 - 9 66 9 9 6: : 6- 966 CE661 . EP is in... 06 cm H N and eR. P 1,0 9/qG Nj5 To the 24 1143 Pg (1! ) ' " 4900/) (fil. F L YOU itself s R the c, Euro . ; w - 0 5-5; 29 Descriptive Report dea Patent of In vencao of "PROCESS FOR PREPARATION 2- (2-HENSOILA SU  BSTITUIDA) - 4- (OXI-SUBSTITUIDO OR TIO-SUBSTITUIDO) - 1,3 CICLOHEXANODIONAS ". The order of Patent EP 135.191; EP 186. 118; EP 186,119 and EP 186,120 mention certain herbicidas composites to it that can have the following formula of 2 structure R R 1 C>, b R C \ to the OR where R R 5, R 7 is substantially as if of they finish below and R it is alquila in C 1 - C 4. Description of the Invention the present invention mentions a2- (2-ben zoila substituted) - 4- (substituted Oxi or uncle substitutes of) - 1,3-ciclohexanodionas and to its use as herbici of. One form of present dea accomplishment in vencao consists of a herbicida composition that ompreen m 'et VO: 1, 1 u 86,8 CLAIMS 1. Process for preparation of 2- (2 - SUBSTITUTED BENZOILA) - 4- (OXI-SUBSTITUIDO OR TIO-SUBSTI TUIDO) - 1,3 CICLOHEXANODIONAS ", dea 2 formula R R 1 o 1. 0 where x is oxi, uncle, sulfinila or sulfoni went; R is halogenio; alquila in C I - C 2 alcoxi in C 1 - C 2; trifluormetoxi; difluormetoxi; ni tro; cyan; haloalquila in C 1 - C 2; R SO n - that n is  or 2 and R it 1 - C 2, trifluormetila or difluor is alquila C metila;  it is. R1 and hydrogen; alquila C l - C 4, fenila or fenila substituted; 2. R and hydrogen or alquila C l - C 4; OR 1. t.)... GIN cm 11 : : 7 - i i i i i . The HOLLOW MAC O* OF the 0 CO 45061 1 and R 1 and R2 is jointly alquile in C - C R 3. is hydrogen, 2 alquila C I - C 4 ' fenila or fenila substituted, on condition that R 1 and R 3 are not both fenila or fenila substitutes of; R 4 hydrogen or alquila C l - C 4; R 5 hydrogen or alquila C 1 - C 4; R 6 hydrogen, alquila C 1 - C 4, haloalquila C 1 - C 4 or fenila; 7. R and R 8 is independently (1) hydrogen; (2) halogenio; (3) alquila C 1 - C 4; (4) al coxi C 1 - C 4; (5) trifluormetoxi; (6) cyan; (7) nitro;  (8) haloalquila in C 1 - C 4; (9) R b SC n - where n is whole number 0, 1 or 2; R b is (a) alquila C 1 - C 4, (b) alquila C 1 - C 4 substituted by cyan halogenio or; (c) fenila; or (d) benzila; (10) - NR c xd that R and R d are independently hydrogen or alquila C 1 - C 4; (11) R and C (0) - where R and is alquila in C l - C 4 or alcoxi in C 1 - C 4; or (12) - 2 S0 NRc R d where R c and R d co is such me if defined; e (13) - N (R c) C (0) R d where R c and R d as is defined, the process being characterized pe lo fact of that it understands:  a) reacting diona with the formula and eee Of Gee ee HOLLOW COMPACT DISC ee miemo you I: II and HOLLOW GO and and * M and Me the j)) 0. ee ebe cm and Dee it where R 1 6 R and X as is defined, with rea people of benzoila substituted dea formula fl where R, 7 R and R 8 as are defined and Y is haloge river, alquila - C (0) - 0-C l - C 4, alcoxi - C (0) - 0-C 1 - 0 C 4 or 1. -0-C (0) where R, 7 R and R 8 in this dea part cos molecule is identi to those in the reagents shown above with for me in the one mol of a moderate base forming one ester enol intermediate dea formula where R 8 R and X as is defined, and the stage (b) reaction of one mol deo intermediate ester enol with 1 the 4 soft ones of a moderate base, and of 0,01 mol about 0,5 mol or more than a source of cianeto Para in the one in the o in the one in the o, * 1. " , CDID, 8. " ,9 i 115. l i t 8. r I \ l and, ra to form a dea compound formula c where moderate base and R 8 R and X in agreement of are finidos above. 2. Process, in accordance with reivindi dogfish 1, characterized for the fact of that X is halogenio, the moderate base is trialquilamina C 1 - C 6, piridina, to car bonato of alkaline metal or fosfato of alkaline metal and the source of cianeto of alkaline metal, alifaticos cianohidrinas of alquil metila C1-C4 ketones, cianohidrinas of ben zaldeido or aldehydes C 9 -0 5; cianohidrinas, cianeto of zinc, cianetos of tri (alquila inferior) itself lila or cianeto of hydrogen. 3. Process, in accordance with reivindi dogfish 2, characterized for the fact of that X is chlorine, the moderate base is trialquilamina C 1 - C 6, born piridina, carbo of sodium or fosfato of sodium and the source of cianeto are cianeto of potassium, cianohidrina of acetone or cia hydrogen grandson. j). i. ) nes me the,1 XIV I t hr; 1. 4 4: 1:  e. 1 THE 198 NIIII IDO@. 1:4 - 14 MOI; SUMMARY DEA INVENTION Pioneer patent of "PROCESS FOR PREPARATION OF 2- (2-BENZOILA SUBSTITUTED) - 4- (OXI-SUBSTI TU/DE OR the TIO-SUBSTITUIDO) - 1,3 CICLOHEXANODIONAS". Composites of formula 1. 0 where X is oxi, uncle, sulfinila or sulfonila;  R is halogenio; alquila in C 1 - C 2; alcoxi in C 1 - C 2; trifluormetoxi; difluormetoxi; nitro; cyan;  halogenoalquila in C 1 - C 2; R SO n - where n is or the 2 and - R and alquila in C 1 - C 2, trifluormetila or difluormetila; R 1 is hydrogen; alquila in C1C 4, feni la or fenila substituted; 2. R and hydrogen or alquila in C 1 - C 4; or R 1 and R 2 are jointly alquileno in Know. fil MI Oure is. R3 and hydrogen, alquila in C 1 - C 4, feni la or fenila substituted, on condition that R i and R 3 fenila or fenila is not both substituted;  it is. R4 and hydrogen or alquila in C 1 - C 4;  r and hydrogen or alquila in C are 5 1 - C 4;  it is. R6 and hydrogen, alquila in C 1 - C 4, ha logencalquila in C 1 - C 4 or fenila; 7. R and R 8 hi is independently (1) drogenio; (2) halogenio; (3) alquila in C 1 - C 4; (4) al cenci in C 1 - C 4; (5) trifluormetoxi; (6) cyan; (7) ni tro; (8) halogencalquila in C 1 - C 4; (9) R b SO n - where n is the whole number, 1 or 2; R b is (a) alquila in C 1 - C 4 (b) alquila in C1-C4 substituted for cyan halogenio or; (c) fenila; or (d) benzila; (10) - NR c R d where R c and R d is independently hydrogen or alqui la in C 1 - C; (11) R and C - where R, is alquila in (0) C 1 - C 4 or alcoxi in C 1 - C 4; or (12) - S0 2 NR c R d where R c and R d is as if defined; e (13) - N (R .deg.) C (0) R d where R c and R d is as if defined; e its you leave.  Machine Translated
法律状态
(BRPI8705524) LEGAL DETAILS FOR BR8705524  Actual or expected expiration date=2007-10-15    Legal state=DEAD    Status=EXPIRED     Event publication date=1987-10-15  Event code=BR/APP  Event indicator=Pos  Event type=Examination events  Application details  Application country=BR BR8705524  Application date=1987-10-15  Standardized application number=1987BR-0005524     Event publication date=1988-05-24  Event code=BR/A  Event type=Examination events  Published application  Publication country=BR  Publication number=BR8705524  Publication stage Code=A  Publication date=1988-05-24  Standardized publication number=BR8705524     Event publication date=1992-11-24  Event code=BR/A1  Event indicator=Pos  Event type=Examination events  Published application  Publication country=BR  Publication number=BRPI8705524  Publication stage Code=A1  Publication date=1992-11-24  Standardized publication number=BRPI8705524     Event publication date=2000-12-26  Event code=BR/PC  Event type=Change of name or address  Event type=Reassignment  Transfer Transferencia deferida ZENECA AG PRODUCTS INC. (US)     Event publication date=2007-10-15  Event code=BR/EEDX  Event indicator=Neg  Event type=Event indicating Not In Force  Patent has expired    Event publication date=2008-07-29  Event code=BR/B21A  Event indicator=Neg  Event type=Event indicating Not In Force  Expiry acc. art. 78, item i of ipl- expiry of the term of protection Extincao de patente e certificado de adicao de invencao: extincao - art. 78 inciso i da lpi PATENTE EXTINTA EM 15/10/2002     Event publication date=2018-03-20  Event code=BR/B1  Event indicator=Pos  Event type=Event indicating In Force  Granted patent / Granted pipeline patent  Publication country=BR  Publication number=BRPI8705524  Publication stage Code=B1  Publication date=2018-03-20  Standardized publication number=BRPI8705524     Event publication date=2018-03-20  Event code=BR/B15K  Event type=Examination events  Others concerning applications: alteration of classification Outros referentes a pedidos: alteracao de classificacao IPC: C07C 321/00 (2006.01), A01N 35/06 (2006.01), A01N
专利类型码
AA1B1
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