公开号/公开日

US2017029483 A1 2017-02-02 [US20170029483] / 2017-02-02

申请号/申请日

2016US-15267285 / 2016-09-16

发明人

PARKHURST MARIA R;MORGAN RICHARD A;ROSENBERG STEVEN A;ROSATI SHANNON FAITH;

申请人

US SECRETARY DEPT OF HEALTH & HUMAN SERV;

主分类号

IPC分类号

C07K-014/725G01N-033/574

摘要

(US20170029483) The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for NY-ESO-1.  Also provided are related polypeptides, proteins, nucleic acids, recombinant expression vectors, isolated host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions.  The invention further provides a method of detecting the presence of cancer in a mammal and a method of treating or preventing cancer in a mammal using the inventive TCRs or related materials.

机翻摘要

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地址

代理人

代理机构

;

优先权号

2012US-61650020 2012-05-22 2013WO-US42162 2013-05-22 2014US-14401893 2014-11-18 2016US-15267285 2016-09-16

主权利要求

(US20170029483) 28. A method of detecting the presence of cancer in a mammal, comprising: (a) contacting a sample comprising one or more cells from the mammal with an isolated host cell or a population thereof, thereby forming a complex, and (b) detecting the complex, wherein detection of the complex is indicative of the presence of cancer in the mammal, wherein the isolated host cell expresses a T-cell receptor (TCR) having antigenic specificity for NY-ESO-1 (SEQ ID NO: 1) and comprising a murine variable region, wherein the TCR comprises the aminoacid sequences of SEQ ID NOs: 3-8. 30. A method of treating or preventing cancer in a mammal, the method comprising administering to the mammal an isolated host cell or a population thereof to the mammal in an amount effective to treat or prevent cancer in the mammal wherein the isolated host cell expresses a T-cell receptor (TCR) having antigenic specificity for NY-ESO-1 (SEQ ID NO: 1) and comprising a murine variable region, wherein the TCR comprises the aminoacid sequences of SEQ ID NOs: 3-8.

法律状态

(US20170029483) LEGAL DETAILS FOR US2017029483  Actual or expected expiration date=2033-05-22    Legal state=ALIVE    Status=PENDING     Event publication date=2016-09-16  Event code=US/APP  Event indicator=Pos  Event type=Examination events  Application details  Application country=US US15267285  Application date=2016-09-16  Standardized application number=2016US-15267285     Event publication date=2016-09-16  Event code=US/EXMR  Event type=Administrative notifications  USPTO Examiner Name Primary Examiner: MARTINEZ, TARA L    Event publication date=2016-09-16  Event code=US/ART  Event type=Administrative notifications  USPTO Art Group  ART=1675     Event publication date=2016-09-16  Event code=US/DK  Event type=Examination events  Attorney Docket Number Docket Nbr: 726472 Customer Nbr: 45733    Event publication date=2016-09-16  Event code=US/ENT  Event type=Administrative notifications  Business Entity Status: UNDISCOUNTED    Event publication date=2016-09-16  Event code=US/AIA  Event type=Administrative notifications  First Inventor File Indicated:  AIA=No     Event publication date=2016-09-16  Event code=US/PTARDY  Event indicator=Pos  Event type=Examination events  Patent Term Adjustment - Ready for Examination    Event publication date=2016-09-16  Event code=US/IDS  Event type=Examination events  Event type=OAI  Information Disclosure Statement Filed    Event publication date=2016-09-16  Event code=US/ENTYSTA  Event type=Administrative notifications  Entity Status Set to Undiscounted    Event publication date=2016-10-26  Event code=US/DOCK  Event indicator=Pos  Event type=Examination events  Case Docketed to Examiner in GAU    Event publication date=2016-10-26  Event code=US/APPFILEREC  Event type=Administrative notifications  Event type=OAO  Filing Receipt    Event publication date=2017-02-02  Event code=US/A1  Event type=Examination events  Application published  Publication country=US  Publication number=US2017029483  Publication stage Code=A1  Publication date=2017-02-02  Standardized publication number=US20170029483     Event publication date=2017-02-02  Event code=US/PGPUBN  Event indicator=Pos  Event type=Examination events  Event type=OAO  PG-Pub Issue Notification    Event publication date=2017-03-30  Event code=US/IDS  Event type=Examination events  Event type=OAI  Information Disclosure Statement Filed    Event publication date=2017-04-28  Event code=US/CTNF  Event type=Examination events  Event type=OA  Event type=OAO  Non-Final Rejection    Event publication date=2017-05-10  Event code=US/IDS  Event type=Examination events  Event type=OAI  Information Disclosure Statement Filed

专利类型码

A1

国别省市代码

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