Drug delivery carrier for targeted and controlled drug release is very important but challenging. In this work, a nano-sized metal-organic frameworks (MOFs)-based magnetic core-shell nanoparticles (NPs) has been designed for targeted drug delivery. Fe3O4@MIL-100(Fe) magnetic NPs were successfully prepared by a facile step-by-step assembly method. By the combination of the high porosity of MOFs shell and the magnetic characteristics of Fe3O4 core, making Fe3O4@MIL-100(Fe) magnetic NPs as an excellent drug delivery system. Significantly, the anti-inflammatory drug Ibuprofen (IBU) was effectively loaded on the magnetic NPs with a loading capacity of 0.31gg(-1), and it took as long as 70h to release IBU completely in PBS buffer solution at 37 degrees C. This work demonstrates that the nano-sized MOFs-based magnetic NPs are promising candidates for targeted drug delivery applications.