Rational synthesis of magnetic Fe_3O_4@MOF nanoparticles for sustained drug delivery 机翻标题: 暂无翻译,请尝试点击翻译按钮。

来源
Journal of porous materials
年/卷/期
2019 / 26 / 3
页码
813-818
ISSN号
1380-2224
作者单位
Univ Sci & Technol China, Dept Pharm, Affiliated Hosp 1, Hefei 230031, Peoples R China|Anhui Prov Canc Hosp, Hefei 230031, Peoples R China;Hefei Ctr Dis Control & Prevent, Hefei 230022, Anhui, Peoples R China;Anhui Agr Univ, Dept Appl Chem, Hefei 230036, Anhui, Peoples R China;Anhui Agr Univ, Dept Appl Chem, Hefei 230036, Anhui, Peoples R China;Anhui Agr Univ, Dept Appl Chem, Hefei 230036, Anhui, Peoples R China;
作者
Ke, Xiang;Song, Xiaoqiong;Qin, Nianqiao;Cai, Yingrun;Ke, Fei;
摘要
Drug delivery carrier for targeted and controlled drug release is very important but challenging. In this work, a nano-sized metal-organic frameworks (MOFs)-based magnetic core-shell nanoparticles (NPs) has been designed for targeted drug delivery. Fe3O4@MIL-100(Fe) magnetic NPs were successfully prepared by a facile step-by-step assembly method. By the combination of the high porosity of MOFs shell and the magnetic characteristics of Fe3O4 core, making Fe3O4@MIL-100(Fe) magnetic NPs as an excellent drug delivery system. Significantly, the anti-inflammatory drug Ibuprofen (IBU) was effectively loaded on the magnetic NPs with a loading capacity of 0.31gg(-1), and it took as long as 70h to release IBU completely in PBS buffer solution at 37 degrees C. This work demonstrates that the nano-sized MOFs-based magnetic NPs are promising candidates for targeted drug delivery applications.
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关键词/主题词
Metal-organic frameworks;Porous materials;Magnetic nanoparticles;Core-shell;Drug delivery;
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