(JP6484641) The pesticide-a fungicide of a compound isoxaaolin 机翻标题: 暂无翻译,请尝试点击翻译按钮。

源语言标题
(JP6484641) The pesticide-a fungicide of a compound isoxaaolin
公开号/公开日
JP6484641 JP2016537415 / 2019-03-13 2016-12-01
申请号/申请日
JP2016552230 / 2014-10-30
发明人
CHARLES Q MENG
申请人
MERIAL
主分类号
IPC分类号
A01N-043/80 A01P-007/02 A01P-007/04 A61K-031/422 A61K-031/496 A61K-031/506 A61P-033/00 A61P-033/14 C07D-413/10 C07D-413/12
摘要
(JP6484641)
The present invention relates to novel and inventive isoxazoline of formula (I) and salts thereof: wherein variables D1, D2, D3, D4, D5, R1, B1, B2, B3, R2, R3, R4, R5, R6, Y, Z, L, a and b are described herein are as defined in the description. The invention also relates to parasiticidal and pesticidal compositions comprising the isoxazoline compounds of formula (I), processes for their preparation and their uses to prevent or treat parasitic infections or infestations in animals and as pesticides.
 (From US2015126523 A1)
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地址
代理人
(JP6484641) NISHIJIMA TAKAYOSHI Reg. Nb: 100086771 Takeshi Hisashi Reg. Nb: 100088694 TANAKA SHINICHIRO Reg. Nb: 100094569 Atsushi Hakoda Reg. Nb: 100084663 Kenji Asai Reg. Nb: 100093300 YAMAZAKI KAZUO Reg. Nb: 100119013 Satsuki Ichikawa Reg. Nb: 100123777 HATTORI HIRONOBU Reg. Nb: 100111796 Tashiro Gen Reg. Nb: 100137626
代理机构
优先权号
2013US-61898578 2014WO-US63074
主权利要求
(JP6484641)
1. (I) the formula:
 (I) of isoxazoline compound. [In the formula, D1, D3 and D2 are each independently C-A1 N or, and C FixedDocument_add A3 C-A2 and, D4 and D5 are each C-H and, R1 is halogen, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, cycloalkyl, halocycloalkyl, cycloalkylalkyl or alkylcycloalkyl and, each of which is not substituted, or 1 or more hydroxy, amino, alkyl-or di (alkyl) amino, alkoxy, haloalkoxy, alkylthio or haloalkylthio and substituted, A1, A2, A3, A4 and A5 is independently hydrogen, halogen, hydroxy, amino, alkyl-or di (alkyl) amino, alkyl, cycloalkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio, - CN or - NO2 and, B1, B3 and B2 is independently C-X, each X is independently hydrogen, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio, amino, alkylamino, haloalkylamino, dialkylamino, dihalo alkyl amino, hydroxyalkyl, alkoxyalkyl, alkylthioalkyl or thioalkyl, or - CN and - NO2, or two adjacent - CH=CH-CH=CH -X is by forming the carbon to which they are attached form a naphthalene ring together with the atoms, R2 is hydrogen, halogen, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, hydroxy, alkoxy, amino, alkyl-or dialkylamino, - CN or - NO2 and, R3, R4, R5 and R6 are each independently a hydrogen, halogen, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio, amino, alkylamino, haloalkylamino, dialkylamino, dihalo alkyl amino, hydroxyalkyl, alkoxyalkyl, in which the thioalkyl alkylthioalkyl or, r5 Or R6 and the carbon to which they are bound together to form together with the atoms to C=W, however, R6 and R5 together form C=W group and at least one of a condition, R7 and R8 is independently hydrogen, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, cycloalkyl, aryl, heteroaryl, heterocyclic, thioalkyl, thiohaloalkyl, alkylthioalkyl, hydroxyalkyl or alkoxyalkyl and, Y is hydrogen, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, cycloalkyl, alkylcycloalkyl, cycloalkylalkyl, aryl, heterocycle or heteroaryl, each of which is not substituted, or 1 one or more halogen, hydroxy, amino, alkyl-or di (alkyl) amino, alkyl, cycloalkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio or - CN and substituted, R7S(O) -, R7S(O) 2-,R7C(O) -, R7R8NC(O) -, R7OC(O) -, R7C(O) O-,R7C(O) NR8-, and Y Y-13 Y-1, Y-2, Y-3, Y-4, Y-5, Y-6, Y-7, Y-8, Y-9, Y-10,Y-11,Y-12 is or or, in the formula, and # means the position of the bond,
shown in the formula, each of R9, R10 is independently hydrogen, alkyl, haloalkyl, thioalkyl, alkylthioalkyl, hydroxyalkyl, alkoxyalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, cycloalkyl, aryl, heteroaryl, and heterocyclic, R7S(O) -, R7S(O) 2-, R7C(O) -, R7R8NC(O) -, R7OC(O) -, R7C(O) O-,R7C(O) NR8-, each R11 is independently hydrogen, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio, amino, alkylamino, haloalkylamino, dialkylamino, dihalo alkyl amino, hydroxyalkyl, alkoxyalkyl, alkylthioalkyl and thioalkyl or, each of R12 and R13 is independently hydrogen, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio, amino, alkylamino, haloalkylamino, dialkylamino, dihalo alkyl amino, hydroxyalkyl, alkoxyalkyl, alkylthioalkyl and thioalkyl or, R13 and R12 or they are coupled together with the carbon atom and together form C=W, W, O Z and W1 are independently, NR7 or S and, directly bind L, - CR3R4-, or -O- and - NR8-, a is 1, or 3 and 2, b is 2 or 3 and, n is 4 and 1, 2, 3 or, and m is 0, 2 or 1 in]
2. D1, D2 And D3 are each C-A1, C-A3 C-A2 and in, a compound according to claim 1 of isoxaaolin.
3. B1, Is B2 and B3 is C FixedDocument_add H, according to claim 1 of isoxazoline compound.
4. X is - CH=CH-CH=CH - two form together with the carbon to which they are bound to form a ring together with the atom to naphthalene, of a compound according to claim 1 isoxaaolin.
5. D1, D2 And D3 are each C-A1, and C FixedDocument_add A3 C-A2 and, A2 is hydrogen, A1 and A3 are independently halogen or C1-C4 haloalkyl and in which, the compound according to claim 1 of isoxaaolin.
 6. A compound of the formula (IA) :  (IA) has the structure, in the formula, R1 represents halogen, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, cycloalkyl, halocycloalkyl, cycloalkylalkyl or alkylcycloalkyl and, each of which is not substituted, or 1 or more hydroxy, amino, alkyl-or di (alkyl) amino, alkoxy, haloalkoxy, alkylthio and substituted haloalkthio or, A1 and A3 is independently hydrogen, halogen, hydroxy, amino, alkyl-or di (alkyl) amino, alkyl, cycloalkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio, - CN and - NO2 or, B2 and B1 is independently C-X, each X is independently hydrogen, halogen, alkyl or haloalkyl and, or two adjacent 2 together form - CH=CH-CH=CH X such that they can be coupled to form a naphthalene ring together with the carbon atom, R2 is hydrogen, halogen, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, hydroxy, alkoxy, amino, alkyl-or dialkylamino, - CN or - NO2 and, R3, R4, R5 and R6 are each independently a hydrogen, halogen, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio, amino, alkylamino, haloalkylamino, dialkylamino, dihalo alkyl amino, hydroxyalkyl, alkoxyalkyl, alkylthioalkyl and thioalkyl or, R5 or R6 and the carbon to which they are bound together to form together with the atoms to C=W, however, at least one of the groups R6 and R5 together with the oxidized form under a condition of C=W, R7 and R8 is independently hydrogen, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, cycloalkyl, aryl, heteroaryl, heterocyclic, thioalkyl, thiohaloalkyl, alkylthioalkyl, hydroxyalkyl or alkoxyalkyl and, Y is hydrogen, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, cycloalkyl, alkylcycloalkyl, cycloalkylalkyl, aryl, heterocycle or heteroaryl, each of which is not substituted, or 1 one or more halogen, hydroxy, amino, alkyl-or di (alkyl) amino, alkyl, cycloalkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio and - NO2, R7S(O) -, R7S(O) 2-,R7C(O) -, R7R8NC(O) -, R7OC(O) -, R7C(O) O-,R7C(O) NR8-,-CN or substituted, or is Y Y-13 Y-1, Y-2, Y-3, Y-4, Y-5, Y-6, Y-7, Y-8, Y-9, Y-10,Y-11,Y-12 or (in the formula, # is the position of binding) and,  shown in the formula, each of R9, R10 is independently hydrogen, alkyl, haloalkyl, thioalkyl, alkylthioalkyl, hydroxyalkyl, alkoxyalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, cycloalkyl, aryl, heteroaryl, heterocyclic, R7S(O) -, R7S(O) 2-, R7C(O) -, R7R8NC(O) -, R7OC(O) -, R7C(O) O-,R7C(O) NR8-and, each R11 is independently hydrogen, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio, amino, alkylamino, haloalkylamino, dialkylamino, dihalo alkyl amino, hydroxyalkyl, alkoxyalkyl, in which the thioalkyl or alkylthioalkyl, each of R12 and R13 is independently hydrogen, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio, amino, alkylamino, haloalkylamino, dialkylamino, dihalo alkyl amino, hydroxyalkyl, alkoxyalkyl, alkylthioalkyl and thioalkyl or, R13 and R12 or they are coupled together with the carbon atom and together form C=W, W, and W1 are independently a O Z, s is NR7 or, directly bind L, - CR3R4-, or -O- and - NR8-, a is 1, 2 or 3 and, b is 2 or 3 and, n is 4 and 1, 2, 3 or, and m is 0, 2 or 1 in which, the compound according to claim 1 of isoxaaolin.
 7. (IB) of the formula:  (IB) of isoxazoline compound. [In the formula, R1 is alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, and haloalkynyl, A1 and A3 is independently hydrogen, halogen, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl or haloalkynyl and, B2 and B1 is independently C-X, each X is independently hydrogen, halogen, alkyl or haloalkyl and, or two adjacent groups are combined to form - CH=CH-CH=CH X by which they are attached form a naphthalene ring together with the carbon atom, R2 is hydrogen, halogen, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl or haloalkynyl, R3,R4,R3',R4', R5,R6,R5'and R6 and' are each independently a hydrogen, halogen, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl or haloalkynyl and, R3 and R3 or R4 and/or 'and R4' to which they are bound form together with the carbon atoms C=W, and/or R5 and R6 and/or R5 'and R6' to which they are bound form together with the carbon atoms C=W, however, R4 and R3, R3 'and R4', R6 and R5, or R5 'and R6' at least one of the carbon to which they are attached form a C=W group together with the atoms to condition, R7 and R8 is independently hydrogen, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, cycloalkyl, aryl, heteroaryl, heterocyclic, thioalkyl, thiohaloalkyl, alkylthioalkyl, in which a hydroxyalkyl or alkoxyalkyl and, Y is hydrogen, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, cycloalkyl, alkylcycloalkyl, cycloalkylalkyl, aryl, heterocycle or heteroaryl, each of which is not substituted, or 1 one or more halogen, hydroxy, amino, alkyl-or di (alkyl) amino, alkyl, cycloalkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio, R7S(O) -, R7S(O) 2-,R7C(O) -, and - NO2 R7R8NC(O) -, R7OC(O) -, R7C(O) O-,R7C(O) NR8-,-CN or substituted, or is Y Y-1, Y-2, Y-3, Y-4, Y-5, Y-6, Y-7, Y-8, Y-9, Y-10,Y-11,Y-12 Y-13 and or, in the formula, # is the binding of the display location,  shown in the formula, each of R9, R10 is independently hydrogen, alkyl, haloalkyl, thioalkyl, alkylthioalkyl, hydroxyalkyl, alkoxyalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, cycloalkyl, aryl, heteroaryl, heterocyclic, R7S(O) -, R7S(O) 2-, R7C(O) -, R7R8NC(O) -, R7OC(O) -, R7C(O) O-,R7C(O) NR8-and, each R11 is independently hydrogen, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio, amino, alkylamino, haloalkylamino, dialkylamino, dihalo alkyl amino, hydroxyalkyl, alkoxyalkyl, thioalkyl and or alkylthioalkyl, each of R12 and R13 is independently hydrogen, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio, amino, alkylamino, haloalkylamino, dialkylamino, dihalo alkyl amino, hydroxyalkyl, alkoxyalkyl, alkylthioalkyl and thioalkyl or, R12 or R13 and the carbon to which they are bound form together with the atoms to C=W, W, and W1 are independently a O Z, NR7 and S or, directly bind L, - CR3R4-, or -O- and - NR8-, n is 4 and 1, 2, 3 or, and m is 0, 2 or 1 in]
 8. (IC) formula:  (IC) of isoxazoline compound. [In the formula, R1 is alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, and haloalkynyl, A1 and A3 is independently hydrogen, halogen, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl or haloalkynyl and, B2 and B1 is independently C-X, each X is independently hydrogen, halogen, alkyl or haloalkyl and, or two adjacent groups taken together are - CH=CH-CH=CH X by forming the carbon to which they are attached form a naphthalene ring together with the atoms, R2 is hydrogen, halogen, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl or haloalkynyl and, R3, R4, R5, R6, R5 'and R6' are each independently a hydrogen, halogen, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl or haloalkynyl and, R5 or R6 and the carbon to which they are bound form together with the atoms to C=W, and/or R5 'and R6' to which they are bound form together with the carbon atoms C=W, however, R5 or R5 and R6 'and R6' at least one of the carbon to which they are attached form a C=W group together with the atoms to condition, R7 and R8 is independently hydrogen, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, cycloalkyl, aryl, heteroaryl, heterocyclic, thioalkyl, thiohaloalkyl, alkylthioalkyl, hydroxyalkyl or alkoxyalkyl and, Y is hydrogen, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, cycloalkyl, alkylcycloalkyl, cycloalkylalkyl, aryl, heterocycle or heteroaryl, each of which is not substituted, or 1 one or more halogen, hydroxy, amino, alkyl-or di (alkyl) amino, alkyl, cycloalkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio and - NO2, R7S(O) -, R7S(O) 2-,R7C(O) -, R7R8NC(O) -, R7OC(O) -, R7C(O) O-,R7C(O) NR8-,-CN or substituted, y is Y-13 Y-1, Y-2, Y-3, Y-4, Y-5, Y-6, Y-7, Y-8, Y-9, Y-10,Y-11,Y-12 or and or, in the formula, # is the binding of the display location,  shown in the formula, each of R9, R10 is independently hydrogen, alkyl, haloalkyl, thioalkyl, alkylthioalkyl, hydroxyalkyl, alkoxyalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, cycloalkyl, aryl, heteroaryl, heterocyclic, R7S(O) -, R7S(O) 2-, R7C(O) -, R7R8NC(O) -, R7OC(O) -, R7C(O) O-,R7C(O) NR8-and, each R11 is independently hydrogen, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio, amino, alkylamino, haloalkylamino, dialkylamino, dihalo alkyl amino, hydroxyalkyl, alkoxyalkyl, thioalkyl and or alkylthioalkyl, each of R12 and R13 is independently hydrogen, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio, amino, alkylamino, haloalkylamino, dialkylamino, dihalo alkyl amino, hydroxyalkyl, alkoxyalkyl, alkylthioalkyl and thioalkyl or, R12 or R13 and the carbon to which they are bound form together with the atoms to C=W, W, O Z and independently W1, NR7 and S or, directly bind L, - CR3R4-, or -O- and - NR8-, n is 4 and 1, 2, 3 or, and m is 0, 2 or 1 in]
 9. (ID) formula:  (ID) of isoxazoline compound. [In the formula, A1 and A3 are independently halogen or C1-C4 haloalkyl, B2 and B1 are independently C-X and, each X is independently hydrogen, halogen, alkyl or haloalkyl, or two adjacent groups are combined to form - CH=CH-CH=CH X by which they are attached form a naphthalene ring together with the carbon atom, R2 is C1-C4 alkyl or C1-C4 haloalkyl, R4 and R3 is independently hydrogen, C1-C4 alkyl, C1-C4 haloalkyl or halogen, R3 or R4 and the carbon to which they are bound to form a C=O group together with the atom to, Y is hydrogen, C1-C4 alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, cycloalkyl, alkylcycloalkyl, cycloalkylalkyl, aryl, heterocycle or heteroaryl, each of which is not substituted, or 1 one or more halogen, hydroxy, amino, alkyl-or di (alkyl) amino, alkyl, cycloalkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio and - NO2, R7S(O) -, R7S(O) 2-, R7C(O) -,R7R8NC(O) -, R7OC(O) -,R7C(O) O-,R7C(O) NR8-,-CN or substituted, and is Y-13 Y-1, Y-2, Y-3, Y-4, Y-5, Y-6, Y-7, Y-8, Y-9, Y-10,Y-11,Y-12 or Y or, in the formula, # is the point of attachment to display,  shown in the formula, R7 and R8 is independently hydrogen, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, cycloalkyl, aryl, heteroaryl, heterocyclic, thioalkyl, thiohaloalkyl, alkylthioalkyl, hydroxyalkyl or alkoxyalkyl and, R9 and R10 is independently hydrogen, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkyl or - C1-C4-alkylthio alkyl thio and - C1 FixedDocument_add C4-, each R11 is independently hydrogen, C1-C4 alkyl or C1-C4 haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio, amino, alkylamino, haloalkylamino, dialkylamino, dihalo alkyl amino, hydroxyalkyl, alkoxyalkyl, thioalkyl and or alkylthioalkyl, each of R12 and R13 is independently hydrogen or C1-C4 alkyl, and W1 is O W and, directly bind L, - CR3R4-, or -O- and - NR8-, n is 4 or is 1, 2, 3, m is 0 and, which is 1 or 2]
 10. (IE) formula:  (IE) of isoxazoline compound. [In the formula, C1-C4 or A1 and A3 are independently haloalkyl halogen, B2 and B1 is independently C-X, each X is independently hydrogen, halogen, alkyl or haloalkyl, or two adjacent - CH=CH-CH=CH X together to form a carbon to which they are attached form a naphthalene ring together with the atoms, R2 is hydrogen, C1-C4 alkyl or C1-C4 haloalkyl, R4 and R3 is independently hydrogen, C1-C4 alkyl, C1-C4 haloalkyl or halogen, R3 or R4 and the carbon to which they are bound to form a C=O group together with the atoms, Y is hydrogen, C1-C4 alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, cycloalkyl, alkylcycloalkyl, cycloalkylalkyl, aryl, heterocycle or heteroaryl, each of which is not substituted, or 1 one or more halogen, hydroxy, amino, alkyl-amino or di (alkyl), alkyl, cycloalkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio and - NO2, R7S(O) -, R7S(O) 2-, R7C(O) -,R7R8NC(O) -, R7OC(O) -,R7C(O) O-,R7C(O) NR8-,-CN or substituted, or is Y Y-1, Y-2, Y-3, Y-4, Y-5, Y-6, Y-7, Y-8, Y-9, Y-10,Y-11,Y-12 Y-13 and or, in the formula, # is the binding of the display location,  ˜C, R7 and R8 is independently hydrogen, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, cycloalkyl, aryl, heteroaryl, heterocyclic, thioalkyl, thiohaloalkyl, alkylthioalkyl, hydroxyalkyl or alkoxyalkyl and, R9 and R10 is independently hydrogen, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkylthio-C1-C4-alkyl or - C1 FixedDocument_add C4-thio alkyl, each R11 is independently hydrogen, C1-C4 alkyl or C1-C4 haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio, amino, alkylamino, haloalkylamino, dialkylamino, dihalo alkyl amino, hydroxyalkyl, alkoxyalkyl, thioalkyl and or alkylthioalkyl, each of R12 and R13 is independently hydrogen or C1-C4 alkyl, and W1 is O W and, directly bind L, - CR3R4-, or -O- and - NR8-, n is 4 or is 1, 2, 3, m is 0 and, which is 1 or 2]
11. R1 CF3 In which, claim 1, 6, 8 or 7 wherein any one of the compounds isoxaaolin 1.
12. B1 And B2 in which the C FixedDocument_add H, either claim 1 1 11 from said isoxazoline compound.
13. B1 And B2 and where C-X, in this case, each X together to form - CH=CH-CH=CH -, the carbon to which they are bound to form a ring together with the atom to naphthalene, of any one of the claim 1 1 12 from said isoxazoline compound.
14. A1 And A3 are independently chloro, fluoro or in the CF3, 1 of any one of the claim 1 from 13 said isoxazoline compound.
15. R2 Is methyl, 1 is any one of claim 1 from 14 said isoxazoline compound.
16. Y is, methyl, ethyl, propyl, 1-l-methylethyl, butyl, 1-methylpropyl, 2-methylpropyl or 1, 1-dimethylethyl in, any one of claim 1 1 15 from said isoxazoline compound.
17. Y is or - CF2CF2CF2CF3 CF3,-CH2CF3,-CF2CF3,-CH2CH2CF3,-CH2CF2CF3,-CF2CF2CF3,-CH2CH2CH2CF3,-CH2CH2CF2CF3,-CH2CF2CF2CF3 is, from 1 to 14 wherein any of the claim 1 of isoxazoline compound.
18. A1 And A3 are independently chloro, fluoro or CF3 and, B2 and B1 and is C FixedDocument_add H, R2 is hydrogen, methyl or CF3 and, R3 and R4 is hydrogen, - NH - and is bonded to or L, - CF2CF2CF2CF3 Y CF3,-CH2CF3,-CF2CF3,-CH2CH2CF3,-CH2CF2CF3,-CF2CF2CF3,-CH2CH2CH2CF3,-CH2CH2CF2CF3,-CH2CF2CF2CF3 is is or and, wherein any of the claims 1 or 6 1 10 from said isoxazoline compound.
19. A1 And A3 are independently chloro, fluoro or CF3 and, B2 and B1 and is C FixedDocument_add X, X together are - CH=CH-CH=CH to which they are bound to form a together with the carbon atoms to form a naphthalene ring, R2 is hydrogen, methyl or CF3 and, R3 and R4 is hydrogen, - NH - and is bonded to or L, - CF2CF2CF2CF3 Y CF3,-CH2CF3,-CF2CF3,-CH2CH2CF3,-CH2CF2CF3,-CF2CF2CF3,-CH2CH2CH2CF3,-CH2CH2CF2CF3,-CH2CF2CF2CF3 or is in and, of any one of the claims 1 or 6 1 10 from said isoxazoline compound.
20. (I) according to claim 1 Eqs compound isoxaaolin of, an infection or infestation of parasites in an animal of a composition for the treatment or prevention.
21. (I) according to claim 1 of formula a compound isoxaaolin, grains, plants, plant propagation material or the wood material has been produced from a composition for the protection from pests.
22. (I) a non-human animal according to claim 1 isoxaaolin of formula which comprises administering a compound, a non-human animal parasites infection or a method for the treatment or prevention of an infestation.
23. Plants, the plants or the soil or water growth, a compound of the formula according to claim 1 (I) comprising contacting isoxaaolin, from attack or infestation by animal pests are growing cereal and a method for protecting plants.
24. Wherein the parasite is a non-human animal in the treatment or prevention of an infection or infestation of a compound according to claim 1 (I) the use of isoxaaolin Eqn.
25. An infection or infestation of parasites of animals for the treatment or prevention of formula in the manufacture of medicaments according to claim 1 (I) the use of the compounds of isoxaaolin.
 26. Having the following structure, isoxazoline compound.
法律状态
GRANTED
专利类型码
B2 A
国别省市代码
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