Methods, kits and devices for promoting cardiac regeneration 机翻标题: 暂无翻译,请尝试点击翻译按钮。

公开号/公开日
US2016326250 A1 2016-11-10 [US20160326250] / 2016-11-10
申请号/申请日
2016US-15147178 / 2016-05-05
发明人
TZAHOR ELDAD;D'UVA GABRIELE MATTEO;SARIG RACHEL;AHARONOV ALLA;HARVEY RICHARD PAUL;UMANSKY KFIR BARUCH;
申请人
VICTOR CHANG CARDIAC RESEARCH INSTITUTE;YEDA RESEARCH & DEVELOPMENT;
主分类号
IPC分类号
A61K-038/18A61K-039/395C07K-016/28G01N-033/50
摘要
(US20160326250) A method of potentiating cardiac regeneration with neuregulin treatment in a subject in need thereof.  The method comprising administering to the subject a therapeutic effective amount of an agent which upregulates activity or expression of ErbB-2, thereby potentiating cardiac regeneration with neuregulin treatment.
机翻摘要
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地址
代理人
代理机构
;
优先权号
2015US-62158111 2015-05-07 2016US-15147178 2016-05-05
主权利要求
(US20160326250) 1. A method of potentiating cardiac regeneration with neuregulin treatment in a subject in need thereof, the method comprising administering to the subject a therapeutic effective amount of an agent which upregulates activity or expression of ErbB-2, thereby potentiating cardiac regeneration with neuregulin treatment. 2. A method of regenerating a cardiac tissue in a subject in need thereof, the method comprising administering to the subject a therapeutic effective amount of an agent which upregulates activity or expression of ErbB-2, wherein said agent is not neuregulin, thereby regenerating the cardiac tissue. 3. A kit for cardiac repair comprising: (i) an agent which upregulates activity or expression of ErbB-2; and (ii) neuregulin. 4. An implantable device for cardiac repair comprising an agent which upregulates activity or expression of ErbB-2. 7. A method of identifying an agent useful in cardiac regeneration, the method comprising: (a) contacting the agent with postnatal cardiomyocytes that do not express ErbB-2; (b) measuring an activity or expression of said ErbB-2 in said cardiomyocytes, wherein an upregulation in said ErbB-2 activity or expression following said contacting is indicative that the agent is useful cardiac tissue regeneration.
法律状态
(US20160326250) LEGAL DETAILS FOR US2016326250  Actual or expected expiration date=2036-05-05    Legal state=ALIVE    Status=PENDING     Event publication date=2016-05-05  Event code=US/APP  Event indicator=Pos  Event type=Examination events  Application details  Application country=US US15147178  Application date=2016-05-05  Standardized application number=2016US-15147178     Event publication date=2016-05-05  Event code=US/EXMR  Event type=Administrative notifications  USPTO Examiner Name Primary Examiner: GAMETT, DANIEL C    Event publication date=2016-05-05  Event code=US/ART  Event type=Administrative notifications  USPTO Art Group  ART=1647     Event publication date=2016-05-05  Event code=US/DK  Event type=Examination events  Attorney Docket Number Docket Nbr: 65911 Customer Nbr: 67801    Event publication date=2016-05-05  Event code=US/ENT  Event type=Administrative notifications  Business Entity Status: SMALL    Event publication date=2016-05-05  Event code=US/AIA  Event type=Administrative notifications  First Inventor File Indicated:  AIA=Yes     Event publication date=2016-05-05  Event code=US/PTARDY  Event indicator=Pos  Event type=Examination events  Patent Term Adjustment - Ready for Examination    Event publication date=2016-05-05  Event code=US/ENTYSTA  Event type=Administrative notifications  Entity Status Set to Undiscounted    Event publication date=2016-05-12  Event code=US/SMALL  Event type=Administrative notifications  Appl Has Filed a Verified Statement of Micro to Small Entity Status    Event publication date=2016-05-13  Event code=US/APPFILEREC  Event type=Administrative notifications  Event type=OAO  Filing Receipt    Event publication date=2016-06-14  Event code=US/IDS  Event type=Examination events  Event type=OAI  Information Disclosure Statement Filed    Event publication date=2016-06-15  Event code=US/DOCK  Event indicator=Pos  Event type=Examination events  Case Docketed to Examiner in GAU    Event publication date=2016-07-28  Event code=US/AS  Event type=Change of name or address  Event type=Reassignment  Assignment Owner: YEDA RESEARCH AND DEVELOPMENT CO. LTD., ISRAEL ASSIGNMENT OF ASSIGNORS INTEREST ASSIGNORS:TZAHOR, ELDAD D'UVA, GABRIELE MATTEO SARIG, RACHEL AND OTHERS SIGNING DATES FROM 20160508 TO 20160518 REEL/FRAME:039277/0193     Event publication date=2016-07-28  Event code=US/AS  Event type=Change of name or address  Event type=Reassignment  Assignment Owner: VICTOR CHANG CARDIAC RESEARCH INSTITUTE, AUSTRALIA  Effective date of the event=2016-07-26  ASSIGNMENT OF ASSIGNORS INTEREST ASSIGNOR:HARVEY, RICHARD PAUL REEL/FRAME:039493/0888     Event publication date=2016-11-10  Event code=US/A1  Event type=Examination events  Application published  Publication country=US  Publication number=US2016326250  Publication stage Code=A1  Publication date=2016-11-10  Standardized publication number=US20160326250     Event publication date=2016-11-10  Event code=US/PGPUBN  Event indicator=Pos  Event type=Examination events  Event type=OAO  PG-Pub Issue Notification    Event publication date=2017-05-18  Event code=US/CTNF  Event type=Examination events  Event type=OA  Event type=OAO  Non-Final Rejection
专利类型码
A1
国别省市代码
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