Pest control compositions and methods 机翻标题: 暂无翻译,请尝试点击翻译按钮。

公开号/公开日
US2009099135 A1 2009-04-16 [US20090099135] / 2009-04-16
申请号/申请日
2008US-12009220 / 2008-01-16
发明人
ENAN ESSAM;
申请人
TYRATECH;
主分类号
IPC分类号
A01N-029/12A01N-043/12A01N-043/16A01N-043/40A01N-043/52A01N-043/56A01N-043/90A01N-047/12A01N-051/00A01N-053/06A01N-057/12A01N-057/14A01N-057/16A01N-065/00A01P-003/00A01P-007/02A01P-007/04
摘要
(US20090099135) Embodiments of the present invention provide compositions for controlling a target pest including a pest control product and at least one active agent, wherein: the active agent can be capable of interacting with a receptor in the target pest; the pest control product can have a first activity against the target pest when applied without the active agent and the compositions can have a second activity against the target pest; and the second activity can be greater than the first activity.
机翻摘要
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地址
代理人
代理机构
;
优先权号
2007US-60885214 2007-01-16 2007US-60885403 2007-01-17 2007US-60889259 2007-02-09 2008US-12009220 2008-01-16
主权利要求
(US20090099135) What is claimed is: 1.  A composition for controlling a target pest comprising a pest control product and at least one active agent, wherein: the active agent is capable of interacting with a receptor in the target pest;the pest control product has a first activity against the target pest when applied without the active agent and the composition has a second activity against the target pest;  and    the second activity is greater than the first activity. 2. The composition of claim 1, wherein the first and second activities are quantified by measuring concentration of the pest control product effective to control the target pest, and a concentration corresponding to the first activity is higher than a concentration corresponding to the second activity. 3. The composition of claim 1, wherein the first and second activities are quantified by measuring disablement effect of the target pest at a standard concentration of pest control product, and the composition exhibits a greater disablement effect than the pest control product applied without the active agent. 4. The composition of claim 1, wherein the first activity persists for a first period, the second activity persists for a second period, and the second period is longer than the first period. 5. The composition of claim 1, wherein the active agent comprises a synergistic combination of at least two receptor ligands. 6. The composition of claim 1, wherein the second activity reflects a synergistic interaction of the active agent and the pest control product. 7. The composition of claim 1, wherein the target pest is selected from the group consisting of a fungus, a plant, an animal, a moneran, and a protist. 8. The composition of claim 7, wherein the target pest is an arthropod species. 9. The composition of claim 8, wherein the arthropod is an insect, an arachnid, or an arachnoid. 10. The composition of claim 7, wherein the target pest is a species belonging to an animal order selected from: Acari, Anoplura, Araneae, Blattodea, Coleoptera, Collembola, Diptera, Grylloptera, Heteroptera, Homoptera, Hymenoptera, Isopoda, Isoptera, Lepidoptera, Mantodea, Mallophaga, Neuroptera, Odonata, Orthoptera, Psocoptera, Siphonaptera, Symphyla, Thysanura, and Thysanoptera. 11. The composition of claim 1, wherein the pest control product is a chlorphenoxy compound. 12. The composition of claim 11, wherein the pest control product is selected from the group consisting of 2,4-D Amine and 2,4D IBE. 13. The composition of claim 1, wherein the pest control product is a carbamate. 14. The composition of claim 13, wherein the pest control product is selected from the group consisting of methomyl, carbofuran, carbaryl, BPMC, carbendazim, carbosulfan, captan hydrochloride, and cartap. 15. The composition of claim 1, wherein the pest control product is an organophosphate. 16. The composition of claim 15, wherein the pest control product is selected from the group consisting of acephate, malathion, diazinon, chlorpyfiros, fenoxycab, edifenphos, febuconazole, chlorphenapyr, magnesium phosphide, metamidophos, and fenitrothion. 17. The composition of claim 1, wherein the pest control product is an organochlorine. 18. The composition of claim 17, wherein the pest control product is selected from the group consisting of DDT, DDE, and heptachlorepoxide. 19. The composition of claim 1, wherein the pest control product is a pyrethroid. 20. The composition of claim 17, wherein the pest control product is selected from the group consisting of cypermethrin, cynmethylin+2,4-D IBE, lambdacyhalothrin, dazomet, cyfluthrin, betacypermethrin, pendimethlin, permethrin, deltamethrin, bifenethrin, alphacypermethrin, fenvalerate, propanil, and esfenvalerate. 21. The composition of claim 1, wherein the pest control product is a neonicotinoid. 22. The composition of claim 19, wherein the pest control product is thiomethoxam, fipronil, clothianidin, imidacloprid. 23. The composition of claim 1, wherein the pest control product comprises at least one of an avermectin, abamectin, spinosad, fluxastrobin, and indoxacarb. 24. The composition of claim 1, wherein the pest control product is a botanical product. 25. The composition of claim 24, wherein the pest control product is selected from the group consisting of: rotenone, nicotine, caffeine, a pyrethrum, an essential oil, and a fixed oil. 26. The composition of claim 1, wherein the pest control product is a fungicide, a nematicide, and insecticide, and acaricide, and a bactericide. 27. The composition of claim 1, wherein the receptor is a G protein-coupled receptor (GPCR). 28. The composition of claim 27, wherein the GPCR is a receptor of the insect olfactory cascade. 29. The composition of claim 28, wherein the receptor is selected from a tyramine receptor, an olfactory receptor Or43a, and an olfactory receptor Or83b. 30. The composition of claim 28, wherein the receptor is an octopamine receptor. 31. The composition of claim 28, wherein binding of the receptor by an ingredient of the composition results in a change in intracellular level of cAMP and/or calcium, and wherein the change is sufficient to permit control of the target pest. 32. The composition of claim 1, wherein control comprises a condition selected from the group consisting of: killing, knockdown, repellency, interference with reproduction, interference with feeding, and interference with a stage of a life cycle of the target pest. 33. A crop protected by the composition of claim 1. 34. A composition for controlling a target pest comprising a pest control product and at least one active agent, wherein: the active agent comprises a ligand of a GPCR of a target pest, wherein binding of the ligand to the GPCR causes a change in a level of cAMP or calcium that permits control of the target pest;the pest control product has a first activity against the target pest, the active agent has a second activity against the target pest, and the composition has a third activity against the target pest;  and    the third activity is greater than the first activity or the second activity. 35. The composition of claim 34, wherein the active agent comprises a synergistic combination of at least two GPCR ligands. 36. The composition of claim 34, wherein the third activity is indicative of synergy between the active agent and the pest control product. 37. A composition for pest control, comprising at least two active ingredients, wherein at least one active ingredient interacts with a G protein-coupled receptor (GPCR) of the pest and wherein at least one active ingredient does not interact with the GPCR, and wherein the at least two active ingredients in combination have a synergistic pest-control activity. 38. The composition of claim 37, wherein the pest is an insect and the GPCR is associated with olfaction, and further wherein the GPCR is absent from vertebrate animals. 39. The composition of claim 37, wherein the synergistic pest-control activity has a coefficient of synergy in excess of 1.5. 40. The composition of claim 37, wherein the synergistic pest-control activity exceeds additive effects of the active ingredients, as measured by the Colby calculation of synergy. 41. The composition of claim 37, wherein the GPCR has a high affinity for the active ingredient in a target organism and wherein the GPCR is absent or has a low affinity for the active ingredient in a non-target organism. 42. The composition of claim 41, wherein the non-target organism is a vertebrate animal. 43. The composition of claim 41, wherein the target organism is selected from a plant, an animal, a fungus, a protist, and a moneran, and the non-target organism is selected from a crop plant, a vertebrate animal, and a non-pest invertebrate. 44. A low-resistance pest-control composition, comprising at least a first active ingredient and a second active ingredient, wherein the first active ingredient interacts with a first molecular target under genetic control within a selected pest, and wherein the second active ingredient interacts with a second molecular target under genetic control within the selected pest, and wherein the ingredients in the composition act together in a complementary manner upon the target pest, and wherein resistance to the composition in an individual target pest requires two separate genetic lesions divergent from a non-resistant population of the pest. 45. The composition of claim 44, wherein the first and second molecular targets comprise two separate molecules encoded or controlled by separate genetic elements. 46. The composition of claim 44, wherein the complementary manner comprises an additive effect of each agent acting separately. 47. The composition of claim 44, wherein the complementary manner comprises a synergistic effect as compared with each agent acting separately. 48. The composition of claim 44, wherein the first molecular target is a GPCR, and wherein the second molecular target is not the same as the first molecular target. 49. A pest-control composition exhibiting high potency against an invertebrate target pest and low toxicity against a vertebrate animal, the composition comprising a synergistic combination of active agents, wherein each active agent interacts with a molecular target with high affinity in the target pest and that is absent form, or present with low affinity, from the vertebrate. 50. The pest control composition of claim 49, wherein at least one active agent is a ligand of a selected GPCR, and wherein at least one active agent is not a ligand of the selected GPCR. 51. The pest-control composition of claim 49, wherein the high target potency and low vertebrate toxicity is expressed as a ratio of LD50(target) versus LD50(vertebrate animal), and wherein the ratio is less than 100:1. 52. A method of pest control comprising contacting a target pest with the composition of claim 1, resulting in control of the pest. 53. The method of claim 52, wherein the receptor is a GPCR. 54. The method of claim 53, wherein the GPCR is a receptor of the insect olfactory cascade. 55. The method of claim 54, wherein the receptor is selected from a tyramine receptor, an olfactory receptor Or43a, and an olfactory receptor Or83b 56.  The method of claim 54, wherein the receptor is an octopamine receptor. 57. The method of claim 54, wherein binding of the receptor by an ingredient of the composition results in a change in intracellular level of cAMP and/or calcium, and wherein the change is sufficient to permit control of the target pest. 58. A method of pest control comprising applying a composition to a target pest or to a substrate associated with a target pest, wherein the composition comprises a pesticide and an active agent comprising at least one receptor ligand, and wherein the pest control comprises affecting a physiological condition of the pest associated with a function of the pesticide while also affecting a function of the receptor associated with the receptor ligand. 59. The method of claim 58, wherein the receptor is a GPCR. 60. The method of claim 59, wherein the GPCR is a receptor of the insect olfactory cascade. 61. The method of claim 60, wherein the receptor is selected from a tyramine receptor, an olfactory receptor Or43a, and an olfactory receptor Or83b. 62. The method of claim 60, wherein the receptor is an octopamine receptor. 63. The method of claim 60, wherein binding of the receptor by an ingredient of the composition results in a change in intracellular level of cAMP and/or calcium, and wherein the change is sufficient to permit control of the target pest. 64. The method of claim 58, wherein the pesticide is selected from a chlorphenoxy compound, a carbamate, an organophosphate, an organochlorine, a pyrethroid, a neonicotinoid, a botanical product, a fungicide, a nematicide, and insecticide, and acaracide, a bactericide. and an avermectin. 65. The method of claim 58, wherein the substrate is a crop plant. 66. The method of claim 58, wherein the substrate is a soil. 67. The method of claim 58, wherein the target pest is selected from the group consisting of wherein the target pest is selected from the group consisting of a fungus, a plant, an animal, a moneran, and a protist. 68. The composition of claim 67, wherein the target pest is an arthropod species. 69. The composition of claim 68, wherein the arthropod is an insect, an arachnid, or an arachnoid. 70. The composition of claim 69, wherein the target pest is a species belonging to an animal order selected from: Acari, Anoplura, Araneae, Blattodea, Coleoptera, Collembola, Diptera, Grylloptera, Heteroptera, Homoptera, Hymenoptera, Isopoda, Isoptera, Lepidoptera, Mantodea, Mallophaga, Neuroptera, Odonata, Orthoptera, Psocoptera, Siphonaptera, Symphyla, Thysanura, and Thysanoptera. 71. The method of claim 58, wherein use of the composition permits an improvement of control of the pest as compared with use of the pesticide alone or the active agent alone. 72. The method of claim 71, wherein the improvement comprises a synergistic interaction of the pest control product with the active agent. 73. The method of claim 71, wherein the improvement comprises an improved result with use of a substantially similar amount of the pest control product. 74. The method of claim 73, wherein the improved result is at least one of: increased killing of the target pest;  increased interference with reproduction by the target pest;  and prolonged effectiveness of the pest control product. 75. The method of claim 71, wherein the improvement comprises a substantially similar result with use of a substantially lower amount of the pest control product and/or the active agent. 76. The method of claim 75, wherein use of the composition permits an agricultural improvement selected from the group consisting of: increased crop yield;  reduced frequency of application of pest control product;  reduced phytotoxicity associated with the pesticide;  and reduced cost or increased value associated with at least one environmental factor. 77. The method of claim 76, wherein the environmental factor is selected from: air quality, water quality, soil quality, detectable pesticide residue, safety or comfort of workers;  and a collateral effect on a non-target organism. 78. A method of developing a composition for pest control, comprising: providing a cell line expressing at least one of: a tyramine receptor, an olfactory receptor Or43a, or an olfactory receptor Or83b, wherein binding of a ligand to any of the receptors causes a change in a level of intracellular cAMP or calcium, and wherein the change is indicative of a potential for invertebrate pest control;contacting the cell with a candidate ligand;detecting a change in the level of cAMP and/or calcium in the cell;identifying the candidate ligand as an active compound for control of an invertebrate pest;  and    combining the active compound with a pesticide to form a composition for pest control, wherein the pesticide does not bind to a receptor bound by the active compound, and wherein a combined effect of the active compound and the pesticide comprises an effect against a target pest that is greater than the effect of either the active compound alone or the pesticide alone. 79. The method of claim 78, wherein the composition further comprises a second active compound capable of binding at least one of the receptors. 80. The method of claim 79, wherein the active compounds cooperate to cause a synergistic change in the level of cAMP and/or calcium in the cell line and/or in a target pest. 81. The method of claim 78, wherein the combined effect of the active compound and the pesticide is synergistic. 82. The method of claim 78, wherein the combined effect is determined by at least one condition selected from the group consisting of: killing, knockdown, repellency, interference with reproduction, interference with feeding, and interference with a stage of a life cycle of the target pest. 83. A method of pest control, comprising, providing a composition comprising at a first and a second active ingredient, wherein the first active ingredient interacts with a receptor of a target pest, and wherein the second active ingredient is a pesticide that does not interact with the receptor of the first active ingredient;  and    contacting the pest with the composition, wherein the contacting results in synergistic pest control. 84. The method of claim 83, wherein the composition further comprises a third active ingredient, wherein the third active ingredient interacts with a receptor of the target pest, and wherein at least the first and third active ingredients in combination synergistically interact to permit control of the target pest. 85. The method of claim 84, wherein the first and third active ingredients bind the same receptor. 86. The method of claim 84, wherein the first and third active ingredients do not bind the same receptor. 87. The method of claim 84, wherein the first, second, and third active ingredients in combination have a synergistic effect that is greater than the effect of any single ingredient and is also greater than the synergistic effect of the first and third ingredients in combination. 88. The method of claim 83, wherein the receptor is a GPCR. 89. The method of claim 88, wherein the receptor is selected from the group consisting of a tyramine receptor, olfactory receptor Or43a, and olfactory receptor Or83b. 90. The method of claim 83, wherein pest control is associated with a receptor-activated alteration in a level of cAMP and/or calcium within the pest. 91. The method of claim 90, wherein the alteration persists for at least about 60 seconds. 92. A method of pest control, comprising: providing a composition comprising at least two active ingredients, wherein at least one active ingredient interacts with a GPCR of a target pest, the composition produces a first level of at least one of intracellular calcium and cyclic AMP in a cell expressing the GPCR on exposure to the cell, and the first level is higher than a second level produced when the cell is contacted with any single active ingredient;  and    contacting the pest with the composition, wherein the contacting results in synergistic pest control. 93. A method for controlling a target pest comprising use of a pest control composition, the composition comprising a pest control product and at least one active agent, wherein: the active agent comprises a ligand of a GPCR of a target pest, wherein binding of the ligand to the GPCR causes a change in a level of cAMP or calcium that permits control of the target pest;the pest control product has a first activity against the target pest, the active agent has a second activity against the target pest, and the composition has a third activity against the target pest;  and    the third activity is greater than the first activity or the second activity. 94. A method of pest control, comprising use of a pest control composition, wherein the composition comprises at least two active ingredients, wherein at least one active ingredient interacts with a G protein-coupled receptor (GPCR) of the pest and wherein at least one active ingredient does not interact with the GPCR, and wherein the at least two active ingredients in combination have a synergistic pest-control activity. 95. A method of pest control permitting low-resistance in a target pest, comprising administering a pest-control composition, the composition comprising at least a first active ingredient and a second active ingredient, wherein the first active ingredient interacts with a first molecular target under genetic control within a selected pest, and wherein the second active ingredient interacts with a second molecular target under genetic control within the selected pest, and wherein the ingredients in the composition act together in a complementary manner upon the target pest, and wherein resistance to the composition in an individual target pest requires two separate genetic lesions divergent from a non-resistant population of the pest. 96. A pest control composition comprising, in combination, a blend of lilac flower oil, D-limonene, thyme oil, and further comprising a pesticide. 97. The composition of claim 96, wherein the pesticide is clothianidin. 98. The composition of claim 96, the blend comprising 10-80% lilac flower oil, 5-60% D-limonene, and 10-80% thyme oil. 99. The composition of claim 96, the blend comprising 20-60% lilac flower oil, 10-45% D-limonene, and 20-60% thyme oil. 100. The composition of claim 96, the blend comprising 42.6% w/w lilac flower oil, 27.35% w/w D-limonene, and 30.08% w/w thyme oil white.
法律状态
(US20090099135) LEGAL DETAILS FOR US2009099135  Actual or expected expiration date=2014-07-28    Legal state=DEAD    Status=LAPSED     Event publication date=2008-01-16  Event code=US/APP  Event indicator=Pos  Event type=Examination events  Application details  Application country=US US922008  Application date=2008-01-16  Standardized application number=2008US-12009220     Event publication date=2008-01-16  Event code=US/EXMR  Event type=Administrative notifications  USPTO Examiner Name Primary Examiner: WAX, ROBERT A    Event publication date=2008-01-16  Event code=US/ART  Event type=Administrative notifications  USPTO Art Group  ART=1615     Event publication date=2008-01-16  Event code=US/ENT  Event type=Administrative notifications  Entity Status Set to Undiscounted Business Entity Status: UNDISCOUNTED    Event publication date=2008-01-16  Event code=US/AIA  Event type=Administrative notifications  First Inventor File Indicated:  AIA=No     Event publication date=2008-01-16  Event code=US/CUST  Event type=Examination events  Attorney/Agent Customer Number Customer Nbr: 36257    Event publication date=2008-03-17  Event code=US/INCD  Event type=Examination events  Event type=OAO  Notice Mailed--Application Incomplete--Filing Date Assigned    Event publication date=2008-03-17  Event code=US/APPFILEREC  Event type=Administrative notifications  Event type=OAO  Filing Receipt    Event publication date=2008-05-22  Event code=US/AS  Event type=Change of name or address  Event type=Reassignment  Assignment  Effective date of the event=2008-04-23  ASSIGNMENT OF ASSIGNORS INTEREST ASSIGNOR:ENAN, ESSAM REEL/FRAME:020999/0183     Event publication date=2008-06-05  Event code=US/RECEIPTUP  Event type=Administrative notifications  Event type=OAO  Filing Receipt - Updated    Event publication date=2008-08-19  Event code=US/RECEIPTUP  Event type=Administrative notifications  Event type=OAO  Filing Receipt - Updated    Event publication date=2008-10-30  Event code=US/DOCK  Event indicator=Pos  Event type=Examination events  Case Docketed to Examiner    Event publication date=2008-12-09  Event code=US/AS  Event type=Change of name or address  Event type=Reassignment  Assignment  Effective date of the event=2008-04-23  ASSIGNMENT OF ASSIGNORS INTEREST ASSIGNOR:ENAN, ESSAM REEL/FRAME:021955/0912     Event publication date=2009-01-26  Event code=US/POAC  Event type=Change of name or address  Change in Power of Attorney (May Include Associate POA)    Event publication date=2009-04-16  Event code=US/A1  Event type=Examination events  Application published  Publication country=US  Publication number=US2009099135  Publication stage Code=A1  Publication date=2009-04-16  Standardized publication number=US20090099135     Event publication date=2009-04-16  Event code=US/PGPUBN  Event indicator=Pos  Event type=Examination events  Event type=OAO  PG-Pub Issue Notification    Event publication date=2010-11-08  Event code=US/RESTREQ  Event type=Examination events  Event type=Corrections  Event type=OAO  Restriction/Election Requirement    Event publication date=2011-03-24  Event code=US/EXIN  Event type=Examination events  Event type=OAO  Event type=INT  Examiner Interview Summary Record (PTOL - 413)    Event publication date=2011-05-12  Event code=US/ELC  Event type=Examination events  Event type=OAI  Response to Election / Restriction Filed    Event publication date=2011-05-12  Event code=US/136G  Event type=OAO  Request for Extension of Time - Granted    Event publication date=2011-06-16  Event code=US/CTNF  Event type=Examination events  Event type=OA  Event type=OAO  Non-Final Rejection    Event publication date=2011-10-20  Event code=US/INVSUM  Event type=Examination events  Event type=OAI  Event type=INT  Interview Summary- Applicant Initiated    Event publication date=2011-10-20  Event code=US/EXIN  Event type=Examination events  Event type=OAO  Event type=INT  Examiner Interview Summary Record (PTOL - 413)    Event publication date=2011-10-24  Event code=US/CTNFR  Event type=Examination events  Event type=OAI  Response after Non-Final Action    Event publication date=2011-10-24  Event code=US/136G  Event type=OAO  Request for Extension of Time - Granted    Event publication date=2011-12-16  Event code=US/CTFR  Event type=Examination events  Event type=OA  Event type=OAO  Final Rejection    Event publication date=2012-06-21  Event code=US/IDS  Event type=Examination events  Event type=OAI  Information Disclosure Statement Filed    Event publication date=2012-06-21  Event code=US/RCEX  Event type=Examination events  Event type=RCE  Event type=OAI  Request for Continued Examination (RCE)    Event publication date=2012-06-21  Event code=US/136G  Event type=OAO  Request for Extension of Time - Granted    Event publication date=2012-06-28  Event code=US/DRCECAP  Event type=RCE  Event type=OAO  Disposal for a RCE / CPA / R129    Event publication date=2012-10-10  Event code=US/IDS  Event type=Examination events  Event type=OAI  Information Disclosure Statement Filed    Event publication date=2013-06-12  Event code=US/IDS  Event type=Examination events  Event type=OAI  Information Disclosure Statement Filed    Event publication date=2013-11-26  Event code=US/CTFR  Event type=Examination events  Event type=OA  Event type=OAO  Final Rejection    Event publication date=2014-05-29  Event code=US/136G  Event type=OAO  Request for Extension of Time - Granted    Event publication date=2014-06-19  Event code=US/DOCK  Event indicator=Pos  Event type=Examination events  Case Docketed to Examiner    Event publication date=2014-07-28  Event code=US/ABNOA  Event indicator=Neg  Event type=Event indicating Not In Force  Event type=OAO  Abandoned -- Failure to Respond to an Office Action
专利类型码
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