源语言标题

(JP2017014255) 癌​の​予防​および​治療​の​ため​の​組成​物​および​方法

公开号/公开日

JP2017014255 A 2017-01-19 [JP2017014255] / 2017-01-19

申请号/申请日

2016JP-0159414 / 2016-08-16

发明人

PERE SANTAMARIA;

申请人

UTI PARTNERSHIP;

主分类号

IPC分类号

A61K-009/14A61K-039/00A61K-039/385A61K-047/02A61K-047/50A61P-035/00A61P-035/04A61P-043/00

摘要

(JP2017014255) PROBLEM TO BE SOLVED: To provide compositions and methods related to immunotherapy and medicine which expand tumor-specific T cells that can efficiently attack cancerous cells.SOLUTION: The invention provides a method of treating a tumor or cancer in a subject comprising administering to the subject a conjugate, consisting of nanoparticles coated with a tumor specific antigen-presenting MHC class I and/or class II molecule and a costimulatory molecule, in an amount sufficient to expand a population of antigen-specific anti-tumorigenic T cells specific to the tumor or cancer.  The antigen-specific anti-tumorigenic T cells include cytotoxic T cells, effector T cells, memory T cells, and helper T cells, which are necessary to initiate and maintain a substantial immune response against metastatic or non-metastatic cancerous, pre-cancerous, or neoplastic cells in vivo.  The method comprises a systemic approach targeting cancerous or pre-cancerous cells that are circulating cells in lymphomas and the like, migratory metastatic cells, and solid tumors.SELECTED DRAWING: Figure 2

机翻摘要

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地址

代理人

代理机构

;

优先权号

2010US-61413330 2010-11-12

主权利要求

法律状态

(JP2017014255) LEGAL DETAILS FOR JP2017014255  Actual or expected expiration date=2031-11-11    Legal state=ALIVE    Status=PENDING     Event publication date=2016-08-16  Event code=JP/APP  Event indicator=Pos  Event type=Examination events  Application details  Application country=JP JP2016159414  Application date=2016-08-16  Standardized application number=2016JP-0159414     Event publication date=2016-12-20  Event code=JP/A521  Event type=Restitution or restoration  Written amendment  Effective date of the event=2016-12-02  JAPANESE INTERMEDIATE CODE: A523     Event publication date=2017-01-19  Event code=JP/A  Event indicator=Pos  Event type=Examination events  Published application  Publication country=JP  Publication number=JP2017014255  Publication stage Code=A  Publication date=2017-01-19  Standardized publication number=JP2017014255     Event publication date=2017-04-21  Event code=JP/A521  Event type=Restitution or restoration  Written amendment  Effective date of the event=2017-04-21  JAPANESE INTERMEDIATE CODE: A523     Event publication date=2017-06-28  Event code=JP/A131  Event indicator=Neg  Event type=Examination events  Notification of reasons for refusal  Effective date of the event=2017-06-28  JAPANESE INTERMEDIATE CODE: A131

专利类型码

A

国别省市代码

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