(EP3097783) Colicin m for the control of ehec 机翻标题: 暂无翻译,请尝试点击翻译按钮。

源语言标题
(EP3097783) Colicin m for the control of ehec
公开号/公开日
EP3097783EP3097783 / 2019-11-132016-11-30
申请号/申请日
EP15181133 / 2015-08-14
发明人
GIRITCH ANATOLIHAHN SIMONESCHULZ STEVESTEPHAN ANETTGLEBA YURIJARCZOWSKI FRANZISKA;
申请人
NOMAD BIOSCIENCE;
主分类号
IPC分类号
A01N-063/02 A01P-001/00
摘要
(EP3097783) The invention provides a method of preventing or reducing contamination of an object such as food with enterohaemorrhagic E . coli (EHEC), comprising contacting said object with colicin M or a derivative thereof.
机翻摘要
暂无翻译结果,您可以尝试点击头部的翻译按钮。
地址
代理人
(EP3097783) Blodig, Wolfgang ; Wächtershäuser & Hartz ([DE]) Reg. Nb: 101167774
代理机构
;
优先权号
2015US-62166379
主权利要求
(EP3097783) 1. Use of colicin M or a derivative thereof for preventing or reducing contamination of an object with enterohaemorrhagic E. coli (EHEC), wherein said object is contacted with said colicin M or said derivative; wherein   (A) said colicin M or its derivative has an N-terminal translocation domain as follows:    the N-terminal translocation domain has amino acid residues 1 to 35 of SEQ ID NO: 1, or    has 1 amino acid substitution, insertion, addition or deletion compared to amino acid residues 1 to 35 of SEQ ID NO: 1, or    has an amino acid sequence identity of at least 97 % to the N-terminal translocation domain of SEQ ID NO: 1, or    has an amino acid sequence similarity of at least 97 % to the N-terminal translocation domain SEQ ID NO: 1;   (B) said colicin M or its derivative comprises a central receptor-binding domain as follows:    the receptor-binding domain has residues 36 to 140 of colicin M of SEQ ID NO: 1, or    has a domain having from 1 to 3 amino acid substitutions, insertions, additions or deletions compared to residues 36 to 140 of SEQ ID NO: 1, or    has an amino acid sequence identity of at least 97 % to the receptor-binding domain of SEQ ID NO: 1, or    has an amino acid sequence similarity of at least 97 % to the receptor-binding domain SEQ ID NO: 1; and   (C) said colicin M or its derivative comprises a C-terminal activity domain as follows:    the activity domain is of residues 141 to 271 of SEQ ID NO: 1, or    the activity domain has from 1 to 5 amino acid residue substitutions, insertions, additions or deletions compared to amino acid residues 141 to 271 of SEQ ID NO: 1, or    the activity domain has an amino acid sequence identity of at least 97% to the activity domain of SEQ ID NO: 1;    wherein contamination of an object with any one or all of the following E. coli serotypes is prevented or reduced: serotype O26:H11, serotype O45:H2, serotype 0103:H11, serotype O111:H8, serotype O157:H7, serotype O145:NM, and serotype O104:H4, and    wherein the use does not comprise treatment of the human or animal body by surgery or therapy. 2. The use according to claim 1, wherein contamination of an object with any one or all of the following E. coli serotypes is prevented or reduced: serotype O26:H11, serotype O45:H2, serotype O103:H11, serotype O111:H8, serotype O145:NM, O157:H7, and O104:H4. 3. The use according to claim 1, wherein said object is contacted with an aqueous solution containing colicin M or its derivative by spraying with said aqueous solution or by dipping said object into said aqueous solution. 4. The use according to any one of claims 1 to 3, wherein said object is food. 5. The use according to claim 4, wherein said food is immersed for at least 10 seconds into an aqueous solution of colicin M or its derivative. 6. The use according to claim 1, wherein said colicin M or its derivative is produced by expression in a plant or in plant cells, followed by removing undesired components from said plant or said plant cells. 7. The use according to claim 4, wherein said food is meat, raw fruit or raw vegetable. 8. The use according to claim 1, which uses colicin M.
法律状态
GRANTED
专利类型码
B1A1
国别省市代码
若您需要申请原文,请登录。

最新评论

暂无评论。

登录后可以发表评论

意见反馈
返回顶部