Department of Chemistry, School of Science, Alzahra University, Vanak, Tehran, Iran;Department of Chemistry, School of Science, Alzahra University, Vanak, Tehran, Iran;Department of Chemistry, School of Science, Alzahra University, Vanak, Tehran, Iran;Department of Chemistry, School of Science, Alzahra University, Vanak, Tehran, Iran;
Mahzad Dehghani;Vahideh Zadsirjan;Manijheh Ghanbarian;Majid M. Heravi;
Background: Alkynes are actually basic chemicals, serving as privileged synthons for planning neworganic reactions for assemblage of a reactive motif, which easily undergoes a further desirable transformation.Name reactions, in organic chemistry are referred to those reactions which are well-recognized and reached tosuch status for being called as their explorers, discoverers or developers. Alkynes have been used in variousname reactions. In this review, we try to underscore the applications of alkynes as privileged synthons in prevalentname reactions such as Huisgen 1,3-dipolar cycloaddtion via Click reaction, Sonogashira reaction, andHetero Diels-Alder reaction.Objective: In this review, we try to underscore the applications of alkynes as privileged synthons in theformation of heterocycles, focused on the selected reactions of alkynes as a synthon or impending utilization insynthetic organic chemistry, which have reached such high status for being included in the list of namereactions in organic chemistry.Conclusion: Alkynes (including acetylene) are an unsaturated hydrocarbon bearing one or more triple C-Cbond. Remarkably, alkynes and their derivatives are frequently being used as molecular scaffolds for planningnew organic reactions and installing reactive functional group for further reaction. It is worth mentioning thatin general, the terminal alkynes are more useful and more frequently being used in the art of organic synthesis.Remarkably, alkynes have found different applications in pharmacology, nanotechnology, as well as beingknown as appropriate starting precursors for the total synthesis of natural products and biologically activecomplex compounds. They are predominantly applied in various name reactions such as Sonogashira, Glaserreaction, Friedel-crafts reaction, Castro-Stephens coupling, Huisgen 1.3-dipolar cycloaddtion reaction via Clickreaction, Sonogashira reaction, hetero-Diels-Alder reaction. In this review, we tried to impress the readers bypresenting selected name reactions, which use the alkynes as either stating materials or precursors. We disclosedthe applications of alkynes as a privileged synthons in several popular reactions, which reached to suchhigh status being classified as name reactions. They are thriving and well known and established name reactionsin organic chemistry such as Regioselective, 1,3-dipolar Huisgen cycloaddtion reaction via Click reaction,Sonogashira reaction and Diels-Alder reaction.