High-Speed Couplings and Cleavages in Microwave-Heated,Solid-Phase Reactions at High Temperatures 机翻标题: 暂无翻译,请尝试点击翻译按钮。

来源
European Journal of Organic Chemistry
年/卷/期
2001 / / N.5
页码
919-925
作者单位
Institute of Chemistry,Karl-Franzens-University Graz,Heinrichstrasse 28,8010 Graz,Austria;
作者
Alexander Stadler;
摘要
A rapid and efficient procedure of flash heating by microwave irradiation is described for the attachment of aromatic and aliphatic carboxylic acids to chloromethylated polystyrene resins via their cesium salts.Significant rate accelerations and higher loadings are observed when the microwaveassisted protocol is compared with the conventional thermal method.Reaction times are reduced from 12-48 h with conventionalheating at 80degC to 5-15 min with microwave flash heating at temperatures up to 200degC.All transformations were carried out in a purpose-built microwave reactor with on-line temperature,pressure,and microwave power control.Kinetic comparison studies have shown that the observed rate enhancements can be attributed to the rapid direct heaing of the solvent (NMP) by microwaves rather than to a specific nonthermal microwave effect.Furthermore,a microwave-assisted cleavage that allows acidolysis of the Merrifield linker with standard trifluoroacetic acid reagents has been developed.
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正文
Alexander Stadler; Institute of Chemistry,Karl-Franzens-University Graz,Heinrichstrasse 28,8010 Graz,Austria; European Journal of Organic Chemistry; N.5 2001; 919-925
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