The Multixenobiotic resistance system as a possible protective response triggered by microplastic ingestion in Mediterranean mussels (Mytilus galloprovincialis): Larvae and adult stages 机翻标题: 暂无翻译,请尝试点击翻译按钮。

来源
Comparative biochemistry and physiology. Toxicology & pharmacology: CBP
年/卷/期
2019 / 219 /
页码
50-58
ISSN号
1532-0456
作者单位
Univ Bologna, Dept Biol Geol & Environm Sci, Via S Alberto 163, I-48123 Ravenna, Italy;Univ Bologna, Dept Biol Geol & Environm Sci, Via S Alberto 163, I-48123 Ravenna, Italy;Univ Bologna, Dept Biol Geol & Environm Sci, Via S Alberto 163, I-48123 Ravenna, Italy;Univ Bologna, Dept Biol Geol & Environm Sci, Via S Alberto 163, I-48123 Ravenna, Italy;Univ Bologna, Dept Biol Geol & Environm Sci, Via S Alberto 163, I-48123 Ravenna, Italy;
作者
Franzellitti, Silvia;Capolupo, Marco;Wathsala, Rajapaksha H. G. R.;Valbonesi, Paola;Fabbri, Elena;
摘要
The emerging paradigm on plastic pollution in marine environments is that micronize particles (MPs) have far more subtle effects than bigger fragments, given their size range overlapping with that of particles ingested by filter-feeders. The impacts include gut blockage, altered feeding and energy allocation, with knock-on effects on widespread physiological processes. This study investigated whether ingestion of polystyrene MPs (PS-MPs) triggers protective processes in marine mussels. The Multixenobiotic resistance (MXR) system is a cytoprotective mechanism acting as an active barrier against harmful xenobiotics and a route of metabolite detoxification. Both larvae and adults were employed in laboratory experiments with different concentrations of 3-mu m PS-MPs (larvae), and 3-mu m and 45-mu m PS-MPs (adults) matching size range of planktonic food through the mussel lifecycle. Embryos grown in the presence of 3-mu m PS-MPs showed significant reduction of MXR activity and down-regulation of ABCB and ABCC transcripts encoding the two main MXR-related transporters P-glycoprotein and the Multidrug resistance-related protein, respectively. In adults, effects of PS-MPs were assessed in haemocytes and gills, which showed different modulation of MXR activity and ABCB/ABCC expression according to MP size (haemocyte and gills) or particle concentration (haemocyte). These data showed that modulation of MXR activity is part of a generalized response triggered by particle ingestion.
机翻摘要
暂无翻译结果,您可以尝试点击头部的翻译按钮。
关键词/主题词
Haemocytes;Gills;Embryos;ABC transporter;P-glycoprotein;Multidrug resistance-related protein;Marine mussels;Polystyrene microplastic;Gene transcription;Efflux activity;Feeding;
若您需要申请原文,请登录。

最新评论

暂无评论。

登录后可以发表评论

意见反馈
返回顶部