Composition for oral delivery of living thing activator 机翻标题: 暂无翻译,请尝试点击翻译按钮。

源语言标题
(JP2016539170) 生物​活性​剤​の​経口​送達​用​組成​物
公开号/公开日
JP2016539170 A 2016-12-15 [JP2016539170] / 2016-12-15
申请号/申请日
2016JP-0536783 / 2014-11-20
发明人
;
申请人
ADVANCED BIO NUTRITION;
主分类号
IPC分类号
A61K-009/10A61K-009/14A61K-009/52A61K-039/00A61K-045/00A61K-047/32A61K-047/36A61K-047/38A61K-047/44A61K-047/48
摘要
(JP2016539170) A process for selective transvinylation of a reactant carboxylic acid with a reactant vinyl ester to give a product vinyl ester and the corresponding acid of the reactant vinyl ester in the presence of one or more ruthenium catalysts, wherein a) the reactant vinyl ester, the reactant carboxylic acid and the ruthenium catalyst are supplied to a reactor, wherein b) the molar ratio of reactant vinyl ester to reactant carboxylic acid is 1:3 to 3:1, and c) the transvinylation reaction is conducted, d) on completion of the transvinylation reaction, the reactant vinyl ester and the corresponding acid are separated from the reaction mixture by distillation, e) the product vinyl ester is separated by distillation from the bottom product of the distillation, and f) the remaining reaction mixture is recycled into the reactor.  (From US2016296469 A1)
机翻摘要
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地址
代理人
代理机构
;
优先权号
2013US-61912958 2013-12-06 2014WO-US66510 2014-11-20
主权利要求
(JP2016539170)  1. Aquatic or being the composition for oral administration of the living thing activator to terrestrial kind, it includes the particle which includes the living thing activator where particle each one is dispersed in the guttulate, the aforementioned guttulate, is dispersed in the matrix which includes the intestinal *** coating polymer, or is coated by the matrix which includes the intestinal *** coating polymer, here, each one of the aforementioned particle, furthermore includes the mucous membrane adhesion polymer, the composition. 2. The aforementioned intestinal *** coating polymer has built a bridge, in claim 1 the composition of statement. 3. The building a bridge medicine for the aforementioned intestinal *** coating polymer, is the metal cation of two value, in claim 2 the composition of statement. 4. The aforementioned mucous membrane adhesion polymer has built a bridge, either of the claim 1-3 in 1 sections the composition of statement. 5. Building a bridge in the aforementioned mucous membrane adhesion polymer, is formed by the assembly of the Tripoli phosphoric acid, in claim 4 the composition of statement. 6. The aforementioned mucous membrane adhesion polymer, is dispersed in the aforementioned guttulate, either of the claim 1-5 in 1 sections the composition of statement. 7. The aforementioned mucous membrane adhesion polymer and the living thing activator have connected, in claim 6 the composition of statement. 8. The aforementioned particle, is diameter of 50 .micro.m or more, either of the claim 1-7 in 1 sections the composition of statement. 9. The aforementioned living thing activator is the immunogen, either of the claim 1-8 in 1 sections the composition of statement. 10. The aforementioned mucous membrane adhesion polymer, [karaginan] and the Quito sun, hyaluronic acid, alginic acid, the optional these derivatives or decoration ones, is the polymer of one or more which is selected from the group which consists of the carboxylic acid functionality polymer, the sulfuric acid functionality polymer, and the amine functionality polymer, either of the claim 1-9 in 1 sections the composition of statement. 11. The aforementioned intestinal *** coating polymer, is the polymer of one or more which is selected from the group which consists of poly- (meta) acrylic acid, alginic acid, the pectin, the carboxymethyl cellulose, the methyl cellulose, and the acetic acid phthalic acid cellulose, either of the claim 1-10 in 1 sections the composition of statement. 12. The aforementioned intestinal *** coating polymer matrix, low viscosity class alginic acid, low includes the methoxy pectin, or those blends, either of the claim 1-11 in 1 sections the composition of statement. 13. The oil, is selected from the group which consists of the fat, the oil, and the wax, either of the claim 1-12 in 1 sections the composition of statement. 14. The aforementioned oil, is the vegetable oil or the animal oil, in claim 13 the composition of statement. 15. To manufacture the composition of statement in claim 1 being method in order, the aforementioned method, in order process below: (A) It was dispersed or to make the water blend form which includes the living thing activator which is melted;   (B) Process (a) converting the aforementioned water blend homogeneously in the oil, it makes the emulsion of the water blend produce in the aforementioned oil;   (C) In the aqueous solution, the intestinal *** coating polymer is included, process (b) the slurry of production ones is made to form;  And (D1) In the aqueous solution which includes the building a bridge medicine for the aforementioned intestinal *** coating polymer, process (c) spraying it does the aforementioned slurry, drips, or fills, makes the particle form, process (a) the aforementioned water blend, furthermore includes the mucous membrane adhesion polymer here, or (D2) Process (c) the particle is made to form from the aforementioned slurry, process (b), the liquid drop of the emulsion is made to form here in the water mucous membrane adhesion polymer, and the aforementioned mucous membrane adhesion polymer builds a bridge, the fact that the intermediate field particle is made to form furthermore is included Thing is included, method. 16. Process (d1) is done, in claim 15 method of statement. 17. Process (d2) is done, in claim 15 method of statement. 18. The process which makes the aforementioned particle form, process (c) making freeze making aforementioned production ones dry, and the fact that it pulverizes is included, in claim 17 method of statement. 19. The process which makes the aforementioned particle form, process (c) includes the fact that spraying it makes dry aforementioned production ones, in claim 17 method of statement. 20. Being delivery method to after the stomach of the living thing activator to the animal, it includes the process which prescribes the composition of statement to claim 9 orally in the aforementioned animal, method. 21. Aquatic or being vaccination method of terrestrial kind, aforementioned aquatically or terrestrial kind, either of the claim 1-14 it includes the process which prescribes the composition of statement to 1 sections orally, here, the aforementioned composition, is the delivery vehicle for the vaccine, method.
法律状态
(JP2016539170) LEGAL DETAILS FOR JP2016539170  Actual or expected expiration date=2034-11-20    Legal state=ALIVE    Status=PENDING     Event publication date=2014-11-20  Event code=JP/APP  Event indicator=Pos  Event type=Examination events  Application details  Application country=JP JP2016536783  Application date=2014-11-20  Standardized application number=2016JP-0536783     Event publication date=2016-12-15  Event code=JP/A  Event indicator=Pos  Event type=Examination events  Published application  Publication country=JP  Publication number=JP2016539170  Publication stage Code=A  Publication date=2016-12-15  Standardized publication number=JP2016539170
专利类型码
A
国别省市代码
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