(US10703741) Covalent inhibitors of PAD4 机翻标题: 暂无翻译,请尝试点击翻译按钮。

源语言标题
(US10703741) Covalent inhibitors of PAD4
公开号/公开日
US10703741US20190276432 / 2020-07-072019-09-12
申请号/申请日
US16/319,006 / 2017-07-27
发明人
Beaumont Edward JeanDevraj RajeshKerry Philip StephenKumaravel GnanasambandamLoke Pui LengMeniconi MircoPalfrey Jordan JohnNorth CarlLecci CristinaTye Heather;
申请人
PADLOCK THERAPEUTICS;
主分类号
IPC分类号
C07D-401/14 C07D-471/04
摘要
(US10703741) The present invention provides compounds of formula I useful as inhibitors of PAD4, compositions thereof, and methods of treating PAD4-related disorders.
机翻摘要
暂无翻译结果,您可以尝试点击头部的翻译按钮。
地址
代理人
(US10703741) Liu Hong
代理机构
;
优先权号
2016US-62367389 2017US-16319006 2017WO-US44194
主权利要求
(US10703741) We claim: 1. A compound of formula I  or a pharmaceutically acceptable salt thereof, wherein:   G is  each R4 is independently selected from  R1 is hydrogen or C1-6 aliphatic;   R2 is hydrogen or C1-10 aliphatic;   X is selected from N or CH;   R3 is R, or OR; and   each R is independently hydrogen or C1-6 aliphatic optionally substituted with 1-3 fluorine atoms. 2. The compound according to claim 1, wherein G is 3. The compound according to claim 1, wherein G is 4. The compound according to claim 1, wherein G is selected from 5. The compound according to claim 1, wherein R1 is methyl. 6. The compound according to claim 1, wherein R2 is C1-10 aliphatic. 7. The compound according to claim 6, wherein R2 is —CH2-cyclopropyl. 8. The compound according to claim 1, wherein X is N. 9. The compound according to claim 1, wherein X is CH. 10. The compound according to claim 1, wherein said compound is selected from  or a pharmaceutically acceptable salt thereof. 11. A pharmaceutically acceptable composition comprising the compound according to claim 1, and a pharmaceutically acceptable carrier, adjuvant, or vehicle. 12. The composition according to claim 11, in combination with an additional therapeutic agent. 13. A method of inhibiting PAD4 in a subject or in a biological sample comprising the step of contacting the PAD4 with a compound according to claim 1.
法律状态
GRANTED
专利类型码
B2A1
国别省市代码
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