(EP2663193) Solution of carbon monoxide for treatment of disease, including sickle cell disease 机翻标题: 暂无翻译,请尝试点击翻译按钮。

源语言标题
(EP2663193) Solution of carbon monoxide for treatment of disease, including sickle cell disease
公开号/公开日
EP2663193 EP2663193 EP2663193 / 2019-05-08 2015-06-10 2013-11-20
申请号/申请日
EP12734547 / 2012-01-10
发明人
GOMPERTS EDWARD D FORMAN HENRY J
申请人
LOS ANGELES CHILDRENS HOSPITAL
主分类号
IPC分类号
A01N-059/04 A61K-009/00 A61K-009/107 A61K-033/00 A61K-047/42 A61K-047/44 A61K-047/46
摘要
(EP2663193)
The invention provides compositions and methods for delivering carbon monoxide (CO) to subjects suffering from inflammatory, cardiovascular, Sickle Cell, and other disease. The compositions are liquids, including Newtonian and non-Newtonian liquids, such as pastes, gels, foams, emulsions, and other non-gaseous compositions, in which CO is dissolved at an amount that, when administered to a patient, provides a therapeutically or prophylactically effective amount of CO to the patient. The compositions can be provided in many forms, including in bottles or cans.
机翻摘要
暂无翻译结果,您可以尝试点击头部的翻译按钮。
地址
代理人
(EP2663193) FRKelly ([IE]) Reg. Nb: 101394806
代理机构
优先权号
2011US-61432843 2011US-61434639 2012WO-US20710
主权利要求
(EP2663193)
1. A liquid composition comprising dissolved gaseous, or entrapped gaseous bubbles of carbon monoxide (CO) in an amount of 30 mg/l or more for use in treating a subject suffering from or at risk of developing a disease that is treatable with CO; the use comprising administering the liquid composition to the subject by way of the gastrointestinal (GI) tract, wherein the amount of CO is an amount sufficient to reduce or eliminate at least one clinical symptom of the disease, prevent development or recurrence of the disease, limit morbidities from the disease, or cure the disease, wherein the disease is a hematologic disease.
2. A liquid composition comprising dissolved gaseous, or entrapped gaseous bubbles of, carbon monoxide (CO) in an amount of 30 mg/l or more for use according to Claim 1, wherein the hematological disease is caused by an abnormal hemoglobin.
3. A liquid composition comprising dissolved gaseous, or entrapped gaseous bubbles of, carbon monoxide (CO) in an amount of 30 mg/l or more for use according to Claim 2, wherein the disease is Sickle Cell Disease, Hemoglobin C Disease, Hemoglobin SC Disease, or Hemoglobin S beta-thalassemia.
4. A liquid composition comprising dissolved gaseous, or entrapped gaseous bubbles of, carbon monoxide (CO) in an amount of 30 mg/l or more for use according to any one of Claims 1-3, further comprising at least one of: protein, lipid, fat, triglyceride, complex carbohydrate, sugar, artificial sugar substitute, fruit juice, carbohydrate, cellulose, fiber, citric acid, artificial flavoring, natural flavoring, gum, pectin, ascorbic acid, preservative, saponin, oil, oil emulsion, and a salt.
5. A liquid composition comprising dissolved gaseous, or entrapped gaseous bubbles of, carbon monoxide (CO) in an amount of 30 mg/l or more for use according to any one of Claims 1-4, wherein the liquid comprises water, ethanol, or both.
6. A liquid composition comprising dissolved gaseous, or entrapped gaseous bubbles of, carbon monoxide (CO) in an amount of 30 mg/l or more for use according to any one of Claims 1-5, wherein administration is by oral ingestion.
7. A liquid composition comprising dissolved gaseous, or entrapped gaseous bubbles of, carbon monoxide (CO) in an amount of 30 mg/l or more for use according to any one of Claims 1-6, wherein the volume of the liquid composition administered per day is 2 liters or less.
8. A liquid composition comprising dissolved gaseous, or entrapped gaseous bubbles of, carbon monoxide (CO) in an amount of 30 mg/l or more for use according to any one of Claims 1-6, wherein the volume of the liquid composition administered per day is 1 liter or less.
9. A liquid composition comprising dissolved gaseous, or entrapped gaseous bubbles of, carbon monoxide (CO) in an amount of 75 mg/l to 4000 mg/l for use according to any one of Claims 1-8.
10. A liquid composition comprising dissolved gaseous, or entrapped gaseous bubbles of, carbon monoxide (CO) in an amount of 50 mg/l to 400 mg/l for use according to any one of Claims 1-8.
法律状态
GRANTED
专利类型码
B1 A4 A1
国别省市代码
若您需要申请原文,请登录。

最新评论

暂无评论。

登录后可以发表评论


意见反馈
返回顶部