(JP2019077720) Hydroxyapatite derivative aggregate 机翻标题: 暂无翻译,请尝试点击翻译按钮。

源语言标题
(JP2019077720) Hydroxyapatite derivative aggregate
公开号/公开日
JP2019077720 / 2019-05-23
申请号/申请日
JP2019014457 / 2019-01-30
发明人
FURUZONO TSUTOMUAZUMA YOSHINAOKOKAYU YASUMITSUKAWABE KARL KAZUSHIGE;
申请人
KINKI UNIVERSITY SOFSERA;
主分类号
IPC分类号
A01N-025/00 A01N-025/08 A01N-059/16 A01P-003/00 A61K-006/033 A61K-006/04 A61L-027/04 A61L-027/12 C01B-025/32 C01B-025/45 C01B-025/455
摘要
(JP2019077720) PROBLEM TO BE SOLVED: To provide a hydroxyapatite derivative aggregate comprising hydroxyapatite derivative particles, which has mild antibacterial activity that has little adverse effect on healthy tissue while maintaining functions of HAp such as excellent biocompatibility, stickiness or adhesion to biological tissues, and low biodegradable and absorptive property. SOLUTION: As an antibacterial material, there is used the hydroxyapatite aggregate, comprising: antibacterial hydroxyapatite derivative particles where at least a part of calcium ions in the crystalline structure of hydroxyapatite are substituted with silver ions; or antibacterial hydroxyapatite derivative particles where at least a part of hydroxide ions in the crystalline structure of hydroxyapatite are substituted with fluoride ions. SELECTED DRAWING: None COPYRIGHT: (C)2019,JPO&INPIT
机翻摘要
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地址
代理人
(JP2019077720) ITOH, Atsushi Reg. Nb: 100105315
代理机构
;
优先权号
2019JP-0014457
主权利要求
(JP2019077720) 1. The crystal structure of the hydroxyapatite at least a portion of calcium ions in the hydroxyapatite is substituted by silver ions from the particle derivative and the anti-microbial, anti-microbial particles of hydroxyapatite and hydroxyapatite derivatives XRD crystal phase is quantified by 90% or more and a purity, the particle size of the hydroxyapatite derivative microbial 10nm-1,000nm is within the range, of the particles of the hydroxyapatite derivative microbial a-axis length of 9. 424Å or more and, hydroxyapatite derivative particles of the particle group. 2. And one of a predetermined microorganism / μl 5.0x104, wherein a concentration of at least 2.47mmol/L in terms of silver ions in the antimicrobial hydroxyapatite particles and derivatives, coexist to prepare a dispersion liquid, the dispersion medium is used to obtain, after 37°C in a 90% ratio is 1 or more McFaiiand and sterilization, wherein the predetermined microorganism, which is Escherichia coli, particles of the particle group according to claim 1 hydroxyapatite derivatives. 3. Wherein the antimicrobial particles of the hydroxyapatite derivative, characterized in that the sintering and hydroxyapatite derivative particles, particles of the particle group according to claim 1 or 2 hydroxyapatite derivatives. 4. The anti-microbial a-axis length of the hydroxyapatite derivative particles of less than or equal to 9. 442Å, the particles of the hydroxyapatite derivative recited in any one of claims 1-3 group.
法律状态
PENDING
专利类型码
A
国别省市代码
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