Myeloperoxidase, a risk indicator for cardiovascular disease 机翻标题: 暂无翻译,请尝试点击翻译按钮。

公开号/公开日
US2016109448 A1 2016-04-21 [US20160109448]US9435808 B2 2016-09-06 [US9435808] / 2016-04-212016-09-06
申请号/申请日
2015US-14984072 / 2015-12-30
发明人
HAZEN STANLEY L;ZHANG RENLIANG;
申请人
CLEVELAND CLINIC;
主分类号
IPC分类号
A61K-031/616C12N-001/28C12Q-001/28G01N-033/573G01N-037/00G06F-019/00G06Q-050/22
摘要
(US9435808) Diagnostic tests for characterizing an individual's risk of developing or having a cardiovascular disease.  In one embodiment the present diagnostic test comprises determining the level of myeloperoxidase (MPO) activity in a bodily sample obtained from the individual or test subject.  In another embodiment, the diagnostic test comprises determining the level of MPO mass in a bodily sample obtained from the test subject.  In another embodiment, the diagnostic test comprises determining the level of one or more select MPO-generated oxidation products in a bodily sample obtained from the test subject.  The select MPO-generated oxidation products are dityrosine, nitrotyrosine, methionine sulphoxide or an MPO-generated lipid peroxidation products.  Levels of MPO activity, MPO mass, or the select MPO-generated oxidation product in bodily samples from the test subject are then compared to a predetermined value that is derived from measurements of MPO activity, MPO mass, or the select MPO-generated oxidation product in comparable bodily samples obtained from the general population or a select population of human subjects.  Such comparison characterizes the test subject's risk of developing CVD.
机翻摘要
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地址
代理人
代理机构
;
优先权号
2001US-60259340 2001-01-02 2001US-60283432 2001-04-12 2002US-10039753 2002-01-02 2007US-11753799 2007-05-25 2015US-14591381 2015-01-07 2015US-14984072 2015-12-30
主权利要求
(US9435808) 1. A method for administering a lipid lowering agent to a human patient based on elevated levels of myeloperoxidase (MPO) comprising: (a) performing an immunological assay comprising contacting a serum or plasma sample with an anti-MPO antibod
法律状态
(US9435808) LEGAL DETAILS FOR US2016109448  Actual or expected expiration date=2022-01-02    Legal state=ALIVE    Status=GRANTED     Event publication date=2015-12-30  Event code=US/APP  Event indicator=Pos  Event type=Examination events  Application details  Application country=US US14984072  Application date=2015-12-30  Standardized application number=2015US-14984072     Event publication date=2015-12-30  Event code=US/EXMR  Event type=Administrative notifications  USPTO Examiner Name Primary Examiner: ROGERS, JAMES L    Event publication date=2015-12-30  Event code=US/ART  Event type=Administrative notifications  USPTO Art Group  ART=1644     Event publication date=2015-12-30  Event code=US/DK  Event type=Examination events  Attorney Docket Number Docket Nbr: CCF-021719 US CON 3-1 Customer Nbr: 26294    Event publication date=2015-12-30  Event code=US/ENT  Event type=Administrative notifications  Business Entity Status: SMALL    Event publication date=2015-12-30  Event code=US/AIA  Event type=Administrative notifications  First Inventor File Indicated:  AIA=No     Event publication date=2015-12-30  Event code=US/PTARDY  Event indicator=Pos  Event type=Examination events  Patent Term Adjustment - Ready for Examination    Event publication date=2015-12-30  Event code=US/PET  Event type=APL  Petition Entered    Event publication date=2015-12-30  Event code=US/IDS  Event type=Examination events  Event type=OAI  Information Disclosure Statement Filed    Event publication date=2015-12-30  Event code=US/ENTYSTA  Event type=Administrative notifications  Entity Status Set to Undiscounted    Event publication date=2016-01-12  Event code=US/SMALL  Event type=Administrative notifications  Appl Has Filed a Verified Statement of Micro to Small Entity Status    Event publication date=2016-01-13  Event code=US/DOCK  Event indicator=Pos  Event type=Examination events  Case Docketed to Examiner in GAU    Event publication date=2016-01-14  Event code=US/APPFILEREC  Event type=Administrative notifications  Event type=OAO  Filing Receipt    Event publication date=2016-02-29  Event code=US/CTNF  Event type=Examination events  Event type=OA  Event type=OAO  Non-Final Rejection    Event publication date=2016-03-29  Event code=US/DC  Event type=Examination events  Terminal Disclaimer Filed    Event publication date=2016-04-06  Event code=US/DC  Event type=Examination events  Terminal Disclaimer Filed    Event publication date=2016-04-21  Event code=US/A1  Event type=Examination events  Application published  Publication country=US  Publication number=US2016109448  Publication stage Code=A1  Publication date=2016-04-21  Standardized publication number=US20160109448     Event publication date=2016-04-21  Event code=US/DC  Event type=Examination events  Terminal Disclaimer Filed    Event publication date=2016-04-21  Event code=US/PGPUBN  Event indicator=Pos  Event type=Examination events  Event type=OAO  PG-Pub Issue Notification    Event publication date=2016-05-05  Event code=US/DC  Event type=Examination events  Terminal Disclaimer Filed    Event publication date=2016-05-23  Event code=US/NOAM  Event indicator=Pos  Event type=Examination events  Event type=OAO  Mail Notice of Allowance    Event publication date=2016-08-05  Event code=US/APRDY  Event indicator=Pos  Event type=Examination events  Application Is Considered Ready for Issue    Event publication date=2016-08-17  Event code=US/ISSM  Event indicator=Pos  Event type=Examination events  Event type=OAO  Issue Notification Mailed    Event publication date=2016-09-06  Event code=US/B2  Event indicator=Pos  Event type=Event indicating In Force  Granted patent as second publication  Publication country=US  Publication number=US9435808  Publication stage Code=B2  Publication date=2016-09-06  Standardized publication number=US9435808
专利类型码
A1B2
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