(US9435808) Diagnostic tests for characterizing an individual's risk of developing or having a cardiovascular disease. In one embodiment the present diagnostic test comprises determining the level of myeloperoxidase (MPO) activity in a bodily sample obtained from the individual or test subject. In another embodiment, the diagnostic test comprises determining the level of MPO mass in a bodily sample obtained from the test subject. In another embodiment, the diagnostic test comprises determining the level of one or more select MPO-generated oxidation products in a bodily sample obtained from the test subject. The select MPO-generated oxidation products are dityrosine, nitrotyrosine, methionine sulphoxide or an MPO-generated lipid peroxidation products. Levels of MPO activity, MPO mass, or the select MPO-generated oxidation product in bodily samples from the test subject are then compared to a predetermined value that is derived from measurements of MPO activity, MPO mass, or the select MPO-generated oxidation product in comparable bodily samples obtained from the general population or a select population of human subjects. Such comparison characterizes the test subject's risk of developing CVD.
(US9435808) 1. A method for administering a lipid lowering agent to a human patient based on elevated levels of myeloperoxidase (MPO) comprising: (a) performing an immunological assay comprising contacting a serum or plasma sample with an anti-MPO antibod
(US9435808) LEGAL DETAILS FOR US2016109448 Actual or expected expiration date=2022-01-02 Legal state=ALIVE Status=GRANTED Event publication date=2015-12-30 Event code=US/APP Event indicator=Pos Event type=Examination events Application details Application country=US US14984072 Application date=2015-12-30 Standardized application number=2015US-14984072 Event publication date=2015-12-30 Event code=US/EXMR Event type=Administrative notifications USPTO Examiner Name Primary Examiner: ROGERS, JAMES L Event publication date=2015-12-30 Event code=US/ART Event type=Administrative notifications USPTO Art Group ART=1644 Event publication date=2015-12-30 Event code=US/DK Event type=Examination events Attorney Docket Number Docket Nbr: CCF-021719 US CON 3-1 Customer Nbr: 26294 Event publication date=2015-12-30 Event code=US/ENT Event type=Administrative notifications Business Entity Status: SMALL Event publication date=2015-12-30 Event code=US/AIA Event type=Administrative notifications First Inventor File Indicated: AIA=No Event publication date=2015-12-30 Event code=US/PTARDY Event indicator=Pos Event type=Examination events Patent Term Adjustment - Ready for Examination Event publication date=2015-12-30 Event code=US/PET Event type=APL Petition Entered Event publication date=2015-12-30 Event code=US/IDS Event type=Examination events Event type=OAI Information Disclosure Statement Filed Event publication date=2015-12-30 Event code=US/ENTYSTA Event type=Administrative notifications Entity Status Set to Undiscounted Event publication date=2016-01-12 Event code=US/SMALL Event type=Administrative notifications Appl Has Filed a Verified Statement of Micro to Small Entity Status Event publication date=2016-01-13 Event code=US/DOCK Event indicator=Pos Event type=Examination events Case Docketed to Examiner in GAU Event publication date=2016-01-14 Event code=US/APPFILEREC Event type=Administrative notifications Event type=OAO Filing Receipt Event publication date=2016-02-29 Event code=US/CTNF Event type=Examination events Event type=OA Event type=OAO Non-Final Rejection Event publication date=2016-03-29 Event code=US/DC Event type=Examination events Terminal Disclaimer Filed Event publication date=2016-04-06 Event code=US/DC Event type=Examination events Terminal Disclaimer Filed Event publication date=2016-04-21 Event code=US/A1 Event type=Examination events Application published Publication country=US Publication number=US2016109448 Publication stage Code=A1 Publication date=2016-04-21 Standardized publication number=US20160109448 Event publication date=2016-04-21 Event code=US/DC Event type=Examination events Terminal Disclaimer Filed Event publication date=2016-04-21 Event code=US/PGPUBN Event indicator=Pos Event type=Examination events Event type=OAO PG-Pub Issue Notification Event publication date=2016-05-05 Event code=US/DC Event type=Examination events Terminal Disclaimer Filed Event publication date=2016-05-23 Event code=US/NOAM Event indicator=Pos Event type=Examination events Event type=OAO Mail Notice of Allowance Event publication date=2016-08-05 Event code=US/APRDY Event indicator=Pos Event type=Examination events Application Is Considered Ready for Issue Event publication date=2016-08-17 Event code=US/ISSM Event indicator=Pos Event type=Examination events Event type=OAO Issue Notification Mailed Event publication date=2016-09-06 Event code=US/B2 Event indicator=Pos Event type=Event indicating In Force Granted patent as second publication Publication country=US Publication number=US9435808 Publication stage Code=B2 Publication date=2016-09-06 Standardized publication number=US9435808
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