公开号/公开日

US2003147858 A1 2003-08-07 [US20030147858]US7749494 B2 2010-07-06 [US7749494] / 2003-08-072010-07-06

申请号/申请日

2001US-10275706 / 2001-05-11

发明人

RENAUD MICHEL;BERNALIER ANNICK;

申请人

ID PHARMA;

主分类号

IPC分类号

A01N-063/00A01N-063/02A23L-001/30A61K-035/74A61K-045/00A61P-001/04C12N-001/20C12Q-001/68

摘要

(US7749494) The invention concerns the use of non-pathogenic hydrogenotrophic acetogenic bacterial strains for preparing a composition for treating or preventing gastrointestinal disorders associated with productions of digestive gases and/or for modulating the microbial balance of the digestive ecosystem in a mammal.  The invention also concerns said pharmaceutical or food compositions, and the methods for monitoring and preparing said strains.

机翻摘要

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地址

代理人

代理机构

;

优先权号

2000FR-0006009 2000-05-11 2001WO-FR01426 2001-05-11

主权利要求

(US7749494) The invention claimed is: 1.  A method of treating gastrointestinal disorders related to the production of hydrogen in the gastrointestinal tract in a mammal, the method comprising administering to a mammal in need thereof a composition comprising Ruminococcus hydrogenotrophicus wherein said method does not remove any existing enteric microbial flora prior to administering said composition orally or rectally and wherein said composition modulates the balance of the microbial flora in the colon and reduces the amount of gaseous hydrogen produced by the existing flora. 2. The method of claim 1, wherein Ruminococcus hydrogenotrophicus remains active in the colon. 3. The method of claim 1, wherein the composition also comprises a pharmaceutically acceptable carrier. 4. The method of claim 1, wherein said mammal is human, canine or feline. 5. The method of claim 1, wherein said gastrointestinal disorder is selected from the group consisting of irritable bowel syndrome, excessive flatulence, meteorism, bloating and abdominal pain.

法律状态

(US7749494) LEGAL DETAILS FOR US2003147858  Actual or expected expiration date=2023-12-08    Legal state=ALIVE    Status=GRANTED     Event publication date=2003-02-06  Event code=US/APP  Event indicator=Pos  Event type=Examination events  Application details  Application country=US US10275706  Application date=2003-02-06  Standardized application number=2001US-10275706     Event publication date=2003-02-06  Event code=US/EXMR  Event type=Administrative notifications  USPTO Examiner Name Primary Examiner: SRIVASTAVA, KAILASH C    Event publication date=2003-02-06  Event code=US/ART  Event type=Administrative notifications  USPTO Art Group  ART=1657     Event publication date=2003-02-06  Event code=US/ENT  Event type=Administrative notifications  Entity Status Set to Undiscounted Business Entity Status: UNDISCOUNTED    Event publication date=2003-02-06  Event code=US/AIA  Event type=Administrative notifications  First Inventor File Indicated:  AIA=No     Event publication date=2003-02-06  Event code=US/DK  Event type=Examination events  Attorney Docket Number Docket Nbr: 029440.00004    Event publication date=2003-02-06  Event code=US/CUST  Event type=Examination events  Attorney/Agent Customer Number Customer Nbr: 4372    Event publication date=2003-02-06  Event code=US/IDS  Event type=Examination events  Event type=OAI  Information Disclosure Statement Filed    Event publication date=2003-04-08  Event code=US/M905  Event type=Examination events  Event type=OAO  Notice of DO/EO Missing Requirements Mailed    Event publication date=2003-04-22  Event code=US/M903  Event indicator=Pos  Event type=Examination events  Event type=OAO  Notice of DO/EO Acceptance Mailed    Event publication date=2003-05-07  Event code=US/DOCK  Event indicator=Pos  Event type=Examination events  Case Docketed to Examiner    Event publication date=2003-08-07  Event code=US/A1  Event type=Examination events  Application published  Publication country=US  Publication number=US2003147858  Publication stage Code=A1  Publication date=2003-08-07  Standardized publication number=US20030147858     Event publication date=2003-10-28  Event code=US/AS  Event type=Change of name or address  Event type=Reassignment  Assignment  Effective date of the event=2003-10-01  ASSIGNMENT OF ASSIGNORS INTEREST ASSIGNORS:RENAUD, MICHEL BERNALIER, ANNICK REEL/FRAME:014635/0863     Event publication date=2003-10-28  Event code=US/AS  Event type=Change of name or address  Event type=Reassignment  Assignment  Effective date of the event=2003-10-01  ASSIGNMENT OF ASSIGNORS INTEREST ASSIGNORS:RENAUD, MICHEL BERNALIER, ANNICK REEL/FRAME:014635/0863     Event publication date=2005-06-28  Event code=US/DOCK  Event indicator=Pos  Event type=Examination events  Case Docketed to Examiner    Event publication date=2005-08-08  Event code=US/RESTREQ  Event type=Examination events  Event type=Corrections  Event type=OAO  Restriction/Election Requirement    Event publication date=2005-09-30  Event code=US/ELC  Event type=Examination events  Event type=OAI  Response to Election / Restriction Filed    Event publication date=2005-09-30  Event code=US/136G  Event type=OAO  Request for Extension of Time - Granted    Event publication date=2005-12-12  Event code=US/CTNF  Event type=Examination events  Event type=OA  Event type=OAO  Non-Final Rejection    Event publication date=2006-05-19  Event code=US/IDS  Event type=Examination events  Event type=OAI  Information Disclosure Statement Filed    Event publication date=2006-05-19  Event code=US/CTNFR  Event type=Examination events  Event type=OAI  Response after Non-Final Action    Event publication date=2006-05-19  Event code=US/136G  Event type=OAO  Request for Extension of Time - Granted    Event publication date=2006-05-19  Event code=US/AINEA  Event type=OAI  Event type=Examination events  Informal or Non-Responsive Amendment after Examiner Action    Event publication date=2006-10-12  Event code=US/DOCK  Event indicator=Pos  Event type=Examination events  Case Docketed to Examiner    Event publication date=2007-03-19  Event code=US/CTFR  Event type=Examination events  Event type=OA  Event type=OAO  Final Rejection    Event publication date=2007-09-26  Event code=US/IDS  Event type=Examination events  Event type=OAI  Information Disclosure Statement Filed    Event publication date=2007-09-26  Event code=US/RCEX  Event type=Examination events  Event type=RCE  Event type=OAI  Request for Continued Examination (RCE)    Event publication date=2007-09-26  Event code=US/136G  Event type=OAO  Request for Extension of Time - Granted    Event publication date=2008-02-20  Event code=US/AS  Event type=Change of name or address  Event type=Reassignment  Assignment  Effective date of the event=2007-01-06  ASSIGNMENT OF ASSIGNORS INTEREST ASSIGNOR:DIGESTAR REEL/FRAME:020534/0674     Event publication date=2008-02-25  Event code=US/DRCECAP  Event type=RCE  Event type=OAO  Disposal for a RCE / CPA / R129    Event publication date=2008-04-28  Event code=US/CTNF  Event type=Examination events  Event type=OA  Event type=OAO  Non-Final Rejection    Event publication date=2008-10-21  Event code=US/EXIN  Event type=Examination events  Event type=OAO  Event type=INT  Examiner Interview Summary Record (PTOL - 413)    Event publication date=2008-10-28  Event code=US/CTNFR  Event type=Examination events  Event type=OAI  Response after Non-Final Action    Event publication date=2008-10-28  Event code=US/136G  Event type=OAO  Request for Extension of Time - Granted    Event publication date=2008-10-28  Event code=US/IDS  Event type=Examination events  Event type=OAI  Information Disclosure Statement Filed    Event publication date=2009-01-21  Event code=US/CTFR  Event type=Examination events  Event type=OA  Event type=OAO  Final Rejection    Event publication date=2009-07-24  Event code=US/RCEX  Event type=Examination events  Event type=RCE  Event type=OAI  Request for Continued Examination (RCE)    Event publication date=2009-07-24  Event code=US/136G  Event type=OAO  Request for Extension of Time - 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专利类型码

A1B2

国别省市代码

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