Iron oxide nanoparticles and methods of use thereof 机翻标题: 暂无翻译,请尝试点击翻译按钮。

公开号/公开日
AU2016219074 A1 2017-10-05 [AU2016219074] / 2017-10-05
申请号/申请日
2016AU-0219074 / 2016-02-12
发明人
KOO HYUN; GAO LIZENG; CORMODE DAVID; NAHA PRATAP
申请人
UNIVERSITY OF PENNSYLVANIA
主分类号
IPC分类号
A01N-059/16;A01P-001/00;A61K-033/26
摘要
(AU2016219074)
The presently disclosed subject matter relates to iron oxide nanoparticle compositions and formulations thereof for: (1) the treatment and elimination of biofilms; (2) the prevention of biofilm formation; (3) biofilm extracellular matrix degradation; (4) the inhibition of bacterial viability and growth within the biofilm; and (5) the prevention of tooth or apatitic demineralization. 
In particular, the presently disclosed subject matter provides a composition for the prevention and treatment of an oral disease (e.g., dental caries) that includes one or more iron oxide nanoparticles and hydrogen peroxide.
机翻摘要
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地址
代理人
代理机构
优先权号
2015US-62115968 2015-02-13 2016WO-US17858 2016-02-12
主权利要求
(AU2016219074)
1. A composition for the prevention and/or treatment of an oral disease comprising: (a) one or more iron nanoparticles; and (b) hydrogen peroxide.
2. The composition of claim 1, wherein the one or more iron nanoparticles comprise nanoparticles conjugated to an enzyme selected from the group consisting of matrix degrading enzymes, peroxide producing enzymes and combinations thereof.
3. A composition for the prevention and/or treatment of an oral disease comprising one or more iron nanoparticles conjugated to one or more enzymes selected from the group consisting of matrix degrading enzymes, peroxide producing enzymes and combinations thereof
4. A composition for the prevention and/or treatment of a biofilm comprising: (a) one or more iron nanoparticles; and (b) hydrogen peroxide.
5. The composition of claim 4, wherein the one or more iron nanoparticles comprise nanoparticles conjugated to an enzyme selected from the group consisting of matrix degrading enzymes, peroxide producing enzymes and combinations thereof.
6. The composition of claim 1, 2 or 3, wherein the oral disease comprises dental caries.
7. The composition of claim 1, 2, 3, 4, 5 or 6, wherein the one or more iron nanoparticles comprise nanoparticles having a diameter of about 1 nm to about 1000 nm.
8. The composition of any one of claims 1-7, wherein the composition further comprises fluoride, copper, calcium phosphate or a combination thereof
9. The composition of any one of claims 1-8, wherein the iron nanoparticles are doped with a metal.
10. The composition of claim 9, wherein the doping metal is selected from the group consisting of manganese, cobalt, calcium, nickel, copper, magnesium, strontium, barium, scandium, titanium, vanadium, chromium, zinc, aluminum, yttrium, zirconium, niobium, molybdenum, ruthenium, rhodium, palladium, hafnium, tantalum, tungsten, rhenium, osmium, iridium, platinum, copper and a combination thereof.
11. The composition of any one of claims 1-10, wherein the one or more iron nanoparticles comprise nanoparticles that have a polymeric coating.
12. The composition of claim 11, wherein the polymeric coating comprises a biopolymer, dextran, chitosan or combinations thereof.
13. The composition of any one of claims 1-10, wherein the one or more iron nanoparticles comprise nanoparticles that do not have a polymeric coating.
14. A composition for the elimination of a biofilm comprising one or more iron nanoparticles and a compound selected from the group consisting of hydrogen peroxide, sodium percarbonate, fluoride, copper calcium phosphate and combinations thereof.
15. The composition of claim 14, wherein the one or more iron nanoparticles comprise nanoparticles conjugated to an enzyme selected from the group consisting of matrix degrading enzymes, peroxide producing enzymes and combinations thereof.
16. The composition of claim 14, wherein the compound is sodium percarbonate.
17. The composition of claim 4 or 14, wherein the biofilm is generated by a biofilm-forming microbe.
18. The composition of claim 17, wherein the biofilm-forming microbe is selected from the group consisting of S. mutans, P. aeruginosas, E. co/i, Efaecalis, B. subtilis, S. aureus, Vibrio cholerae, Candida albicans and a combination thereof
19. The composition of claim 4 or 14, wherein the presence of the biofilm is present on a surface of a tooth, an industrial material, a naval material, skin, mucosal/soft tissue, an interior of a tooth (e.g., endodontic canal), lung (e.g., cystic fibrosis), urinary tract or a medical device.
20. A method of preventing and/or treating a biofilm-associated disease comprising administering to a subject an effective amount of a composition comprising one or more iron nanoparticles.
21. The method of claim 20 further comprising administering to the subject an effective amount of hydrogen peroxide.
22. The method of claim 20 further comprising administering to the subject an effective amount of fluoride.
23. The method of claim 20, wherein the composition further comprises a compound selected from the group consisting of fluoride, copper, calcium phosphate, hydrogen peroxide, sodium percarbonate and combinations thereof.
24. The method of claim 20, wherein the one or more iron nanoparticles comprise nanoparticles conjugated to one or more enzymes selected from the group consisting of matrix degrading enzymes, peroxide producing enzymes and combinations thereof.
25. The method claim 20, wherein the one or more iron nanoparticles comprise nanoparticles that have a polymeric coating.
26. The method claim 20, wherein the one or more iron nanoparticles comprise nanoparticles that do not have a polymeric coating.
27. The method of claim 21, wherein the hydrogen peroxide is administered in a solution that comprises hydrogen peroxide at a concentration from about 0.1% to about 3.0%.
28. The method of claim 21, wherein the hydrogen peroxide is administered in a solution that comprises hydrogen peroxide at a concentration from about 0.1% to about 1.0%.
29. The method of claim 20, wherein the concentration of the iron nanoparticles within the composition is from about 0.01 to about 1.0 mg/ml.
30. The method of claim 20, wherein the biofilm-associated diseases are selected from the group consisting of dental caries, mucosal infections, oral diseases, urinary tract infections, catheter infections, middle-ear infections, wounds, infections of implanted medical devices, bone diseases, human infections and a combination thereof.
31. A method for the prevention, elimination and/or treatment of a biofilm comprising contacting a surface having a biofilm with an effective amount of a composition comprising one or more iron nanoparticles conjugated to a matrix degrading and/or peroxide producing enzyme.
32. The method of claim 31, wherein the biofilm is present on a tooth surface, mucosal/soft-tissue/skin surface, an apatitic surface, an implant surface, a medical device surface, an interior surface of a tooth, a lung surface, a urinary tract surface, an industrial surface, a surface of a naval vessel, a surface of a watercraft, a ship hull or a pipe surface.
33. A method for preventing biofilm formation on a surface comprising contacting the surface with an effective amount of a composition comprising one or more iron nanoparticles.
34. The method of claim 33, wherein the surface is selected from the group consisting of a tooth surface, a mucosal tissue surface, a soft-tissue surface, skin, an apatitic surface, an implant surface, a medical device surface, an industrial surface, a surface of a naval vessel, a surface of a watercraft, a ship hull or a pipe surface.
35. The method of claim 33, further comprising contacting the surface with a solution comprising hydrogen peroxide, wherein the one or more iron nanoparticles and hydrogen peroxide react to form one or more radicals that prevents biofilm formation.
36. A method for the prevention and/or treatment of a biofilm comprising contacting a surface having a biofilm with an effective amount of a composition comprising one or more iron nanoparticles.
37. The method of claim 36, further comprising contacting the surface with a solution comprising hydrogen peroxide, wherein the one or more iron nanoparticles and hydrogen peroxide react to form one or more radicals that digest the biofilm matrix and simultaneously kill embedded bacteria.
38. A method for the prevention of bacterial growth in a biofilm comprising contacting a surface having a biofilm with an effective amount of a composition comprising one or more iron nanoparticles, wherein the one or more iron nanoparticles bind to the surface and releases iron to inhibit bacterial growth within the biofilm.
39. A method for the prevention of tooth or apatitic demineralization comprising contacting a tooth-enamel or an apatitic surface having a biofilm with an effective amount of a composition comprising one or more iron nanoparticles, wherein the one or more iron nanoparticles bind to the surface and/or release iron to inhibit enamel or apatitic dissolution.
40. The method of claim 39, wherein the apatitic surface is a bone surface.
41. A method to prevent formation and/or initiation of a biofilm comprising coating a surface with an effective amount of a composition comprising one or more iron nanoparticles.
42. A kit for the prevention, elimination and/or treatment of a biofilm comprising: (a) a first container comprising a composition comprising one or more iron nanoparticles; and (b) a second container comprising hydrogen peroxide.
43. A kit for the prevention, elimination and/or treatment of a biofilm comprising a composition comprising one or more iron nanoparticles.
44. The kit of claim 43, wherein the composition further comprises hydrogen peroxide or sodium percarbonate in a single container.
45. The kit of claim 43 or 44, wherein the composition further comprises fluoride.
46. An oral care product comprising the composition of any of the claims 1-19.
法律状态
(AU2016219074)
LEGAL DETAILS FOR AU2016219074

Actual or expected expiration date=2036-02-12   
Legal state=ALIVE   
Status=PENDING 



Event publication date=2016-02-12 
Event code=AU/APP 
Event indicator=Pos 
Event type=Examination events 
Application details

Application country=AU AU2016219074 
Application date=2016-02-12 
Standardized application number=2016AU-0219074 



Event publication date=2017-10-05 
Event code=AU/A1 
Event indicator=Pos 
Event type=Examination events 
Open to public inspection

Publication country=AU 
Publication number=AU2016219074 
Publication stage Code=A1 
Publication date=2017-10-05 
Standardized publication number=AU2016219074
专利类型码
A1
国别省市代码
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