Neuroactive substance and uses of one such substance 机翻标题: 暂无翻译,请尝试点击翻译按钮。

公开号/公开日
WO2005056000 A2 2005-06-23 [WO200556000]WO2005056000 A3 2005-08-18 [WO200556000] / 2005-06-232005-08-18
申请号/申请日
2004WO-FR03030 / 2004-11-25
发明人
PETIT KARINA-ETHEL;BIARD JEAN-FRANCOIS;LAPIED BRUNO;GROLLEAU FRANCOISE;HAMON ALAIN;
申请人
UNIVERSITE D ANGERS;UNIVERSITE DE NANTES;
主分类号
IPC分类号
A01N-043/20A61K-031/336C07D-303/16
摘要
(WO200556000) The invention relates to a neuroactive substance which is characterised in that it has formula (O), wherein R1, R2, R3 and R4 are identical or different and are methyl or ethyl radicals.  Preferably, the neuroactive substance comprises 6S-acetyl-4R,5R-dimethyl-1R(10S)-epoxy-2R-hydroxy-7R-acetoxydecahydro naphthalene which can be isolated from Rhytisma fulvum cnidaria.  The inventive neuroactive substance can be used as a pharmacological reagent in research work and is also suitable for use in the fields of industry (insecticides) and health, such as for the treatment of Parkinson's disease.
机翻摘要
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地址
代理人
代理机构
;
优先权号
2003FR-0014167 2003-12-02
主权利要求
(WO200556000) 1. Neuroactive Substance characterized in that she answers the formula (0) in which IH, R2, R3 and R4 are identical or different and are radicals methyl or ethyl. 2. 2. Neuroactive substance according to claim 1 characterized in that she answers the formula (I) 3. 3. Neuroactive substance according to claim 2 characterized in that it is consisted the 6S-acetyl-4R, 5R-dimethyl-Lr (10S) - epoxy-2R hydroxy-7R-acetoxydecahydronaphtalene answering the formula (II) 4. 4. Substance according to claim 3 characterized in this which is extracted from the cnidaire Rhytisma fulvum 5. 5. Subtsance according to the claim 1,2 or 3 characterized in that it is produced by chemical synthesis. 6. 6. Use of a substance according to any of claims 1,2 or 3 for the realization of a pharmacological reagent 7. 7. Use according to claim 6 characterized in that the aforementioned pharmacological reagent is a selective activator of the transitory calcic membrane channels with low threshold of activation. 8. 8. Use of a substance according to any of claims 1,2 or 3 for the realization of an insecticide. 9. 9. Use according to claim 8 characterized in that the aforementioned substance is used in partnership with another insecticide. 10. 10. Use of a substance according to claim 1,2 or 3 for the manufacture of a drug intended to fight against of the diseases related to the disorders of neuronal exitability. 11. 11. Use according to claim 10 for manufacture of a drug activator of the dopaminergique neurons. 12. 12. Use according to claim 11 for manufacture of a drug intended to fight against the maladie de Parkinson. 3. 3. Use according to claim 10 for manufacture of a drug intended to fight against the reduction in the frequency of discharge of the potentials of action of the neurons with pacemaker activity.
法律状态
(WO200556000) LEGAL DETAILS FOR WO2005056000  Actual or expected expiration date=2007-06-02    Legal state=DEAD    Status=LAPSED     Event publication date=2004-11-25  Event code=WO/APP  Event indicator=Pos  Event type=Examination events  Application details  Application country=WO WOFR2004003030  Application date=2004-11-25  Standardized application number=2004WO-FR03030     Event publication date=2005-06-23  Event code=WO/A2  Event type=Examination events  International application published without international search report  Publication country=WO  Publication number=WO2005056000  Publication stage Code=A2  Publication date=2005-06-23  Standardized publication number=WO200556000     Event publication date=2005-06-23  Event code=WO/AK  Event indicator=Pos  Event type=Designated states  Designated states AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW    Event publication date=2005-06-23  Event code=WO/AL  Event indicator=Pos  Event type=Designated states  Designated countries for regional patents BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG    Event publication date=2005-08-18  Event code=WO/A3  Event indicator=Pos  Event type=Examination events  Later publication of ISR with revised front page  Publication country=WO  Publication number=WO2005056000  Publication stage Code=A3  Publication date=2005-08-18  Standardized publication number=WO200556000     Event publication date=2007-06-02  Event code=WO/EETL  Event type=Event indicating Not In Force  PCT Application validity period expired. LEGAL DETAILS FOR DESIGNATED STATE CA2547579  Actual or expected expiration date=2013-09-12    Legal state=DEAD    Status=LAPSED   Corresponding cc:  Designated or member state=CA Corresponding appl: CA2547579  Application date in the designated or member state=2004-11-25   Application number in the designated or member state=2004CA-2547579 Corresponding cc:  Designated or member state=CA Corresponding pat: CA2547579  Publication stage code in the designated or member state=A1  Publication date in the designated or member state=2005-06-23   Publication number in the designated or member state=CA2547579    Event publication date=2006-05-26  Event code=WO/WWE  Event indicator=Pos  Event type=Entry into national phase  Wipo information: entry into national phase Corresponding cc:  Designated or member state=CA     Event publication date=2013-11-07  Event code=CA/STCHG  Patent Status changed by the national office Corresponding cc:  Designated or member state=CA  LEGAL DETAILS FOR DESIGNATED STATE DE  Actual or expected expiration date=2006-06-03    Legal state=DEAD    Status=LAPSED   Corresponding cc:  Designated or member state=DE     Event publication date=2006-06-03  Event code=WO/NENP  Event type=Event indicating Not In Force  Non-entry into the national phase in: Corresponding cc:  Designated or member state=DE     Event publication date=2006-06-03  Event code=WO/WWW  Event indicator=Neg  Event type=Event indicating Not In Force  Wipo information: withdrawn in national office Corresponding cc:  Designated or member state=DE  LEGAL DETAILS FOR DESIGNATED STATE EP1689385  Actual or expected expiration date=2014-06-30    Legal state=DEAD    Status=EXPIRED   Corresponding cc:  Designated or member state=EP Corresponding appl: EP04805558  Application date in the designated or member state=2004-11-25   Application number in the designated or member state=2004EP-0805558 Corresponding cc:  Designated or member state=EP Corresponding pat: EP1689385  Publication stage code in the designated or member state=A2  Publication date in the designated or member state=2006-08-16   Publication number in the designated or member state=EP1689385    Event publication date=2005-08-17  Event code=WO/121  Event type=Designated states  EP: The EPO has been informed by wipo that ep was designated in this application Corresponding cc:  Designated or member state=EP     Event publication date=2006-05-23  Event code=WO/WWE  Event indicator=Pos  Event type=Entry into national phase  Wipo information: entry into national phase Corresponding cc:  Designated or member state=EP     Event publication date=2006-08-16  Event code=WO/WWP  Event indicator=Pos  Event type=Examination events  Wipo information: published in national office Corresponding cc:  Designated or member state=EP     Event publication date=2007-04-11  Event code=WO/WWG  Event indicator=Pos  Event type=Event indicating In Force  Wipo information: grant in national office Corresponding cc:  Designated or member state=EP     Event publication date=2008-03-19  Event code=EP/STCHG  Patent Status changed by the national office Corresponding cc:  Designated or member state=EP  LEGAL DETAILS FOR DESIGNATED STATE US2007161703  Actual or expected expiration date=2014-12-22    Legal state=DEAD    Status=LAPSED   Corresponding cc:  Designated or member state=US Corresponding appl: US10581226  Application date in the designated or member state=2004-11-25   Application number in the designated or member state=2004US-10581226 Corresponding cc:  Designated or member state=US Corresponding pat: US2007161703  Publication stage code in the designated or member state=A1  Publication date in the designated or member state=2007-07-12   Publication number in the designated or member state=US20070161703    Event publication date=2007-02-26  Event code=WO/WWE  Event indicator=Pos  Event type=Entry into national phase  Wipo information: entry into national phase Corresponding cc:  Designated or member state=US     Event publication date=2007-07-12  Event code=WO/WWP  Event indicator=Pos  Event type=Examination events  Wipo information: published in national office Corresponding cc:  Designated or member state=US     Event publication date=2017-12-05  Event code=US/STCHG  Patent Status changed by the national office Corresponding cc:  Designated or member state=US
专利类型码
A2A3
国别省市代码
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