Alpha-cell re-generation combined with conversion to beta cells 机翻标题: 暂无翻译,请尝试点击翻译按钮。

公开号/公开日
WO2016102657 A1 2016-06-30 [WO2016102657] / 2016-06-30
申请号/申请日
2015WO-EP81141 / 2015-12-23
发明人
HECKSHER-SØRENSEN JACOB;COLLOMBAT PATRICK;
申请人
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM);NOVO NORDISK;UNIVERSITE DE NICE SOPHIA ANTIPOLIS;
主分类号
IPC分类号
A61K-031/197A61K-035/39A61K-039/00A61K-045/06A61P-003/10C12N-005/071
摘要
(WO2016102657) The present invention relates to methods of generating a population of beta cells from a population of alpha cells, by contacting said population of alpha cells with GABA or a GABA receptor agonist, in combination with a monoclonal glucagon neutralizing antibody or other alpha cell mass regulating compounds, for an improved diabetes therapy.
机翻摘要
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地址
代理人
代理机构
;
优先权号
2014EP-0199974 2014-12-23
主权利要求
(WO2016102657) 1. A method for producing a population of pancreatic beta cells comprising the step of contacting a population of alpha cells with GABA or a GABA receptor agonist in combination with a glucagon neutralizing monoclonal antibody or other alph
法律状态
(WO2016102657) LEGAL DETAILS FOR WO2016102657  Actual or expected expiration date=2018-06-23    Legal state=ALIVE    Status=PENDING     Event publication date=2015-12-23  Event code=WO/APP  Event indicator=Pos  Event type=Examination events  Application details  Application country=WO WOEP2015081141  Application date=2015-12-23  Standardized application number=2015WO-EP81141     Event publication date=2016-06-30  Event code=WO/A1  Event type=Examination events  Published application with search report  Publication country=WO  Publication number=WO2016102657  Publication stage Code=A1  Publication date=2016-06-30  Standardized publication number=WO2016102657  LEGAL DETAILS FOR DESIGNATED STATE DE  Actual or expected expiration date=2017-06-23    Legal state=DEAD    Status=LAPSED   Corresponding cc:  Designated or member state=DE     Event publication date=2017-06-23  Event code=WO/NENP  Event type=Event indicating Not In Force  Non-entry into the national phase in: Corresponding cc:  Designated or member state=DE  LEGAL DETAILS FOR DESIGNATED STATE EP  Actual or expected expiration date=2034-12-23    Legal state=ALIVE    Status=PENDING   Corresponding cc:  Designated or member state=EP Corresponding appl: EP15817381    Event publication date=2016-08-17  Event code=WO/121  Event type=Designated states  EP: The EPO has been informed by wipo that ep was designated in this application Corresponding cc:  Designated or member state=EP     Event publication date=2017-06-22  Event code=WO/REEP  Event indicator=Pos  Event type=Entry into national phase  Request for entry into the European phase Corresponding cc:  Designated or member state=EP
专利类型码
A1
国别省市代码
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