Functionalized hydroxyapatite/gold composites as "green" materials with antibacterial activity and the process for preparing and use thereof 机翻标题: 暂无翻译,请尝试点击翻译按钮。

公开号/公开日
WO2013187846 A1 2013-12-19 [WO2013187846] / 2013-12-19
申请号/申请日
2013WO-SI00025 / 2013-05-08
发明人
VUKOMANOVIC MARIJA;SKAPIN SRECO DAVOR;SUVOROV DANILO;
申请人
INSTITUT JOZEF STEFAN;
主分类号
IPC分类号
A01N-025/08A01N-059/16A01P-001/00A61K-033/24B82B-003/00B82Y-030/00
摘要
(WO2013187846) New concept was developed for formation of human- and environmental- friendly material able to provide antibacterial activity.  This material is composed of bioceramic (hydroxyapatite), metallic (gold) and organic part containing amino and thiol groups (amino acids) in the form of composite.  Bioceramic part of this material is templating agent applied as a controller of growth and stability of metallic nanoparticles particle.  These metallic nanoparticles have functionalized surface and they are centers of antibacterial activity of composites.  Efficacy of antibacterial activity of these materials depends on selection of surface functionalization providing activity against both Gram-positive and Gram-negative bacteria.  For developed materials this activity is much stronger compare to HAp/Ag composite which shows ability for their use as more favorable replacement of toxic silver.  Materials were synthesized using sonochemical method, which has been developed as a novel, "green" approach for their formation.
机翻摘要
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地址
代理人
代理机构
;
优先权号
2012SI-0000204 2012-06-15
主权利要求
(WO2013187846) 1. Claims 1. Antibacterial composite comprising: a) a hydroxyapatite substrate, b) gold nanoparticles, and c) organic molecules, wherein the gold nanoparticles are attached to the hydroxyapatite substrate surface; the gold nanoparticles are covered by the organic molecules; the organic molecules are selected from the group consisting of amino acids, amines and thiols; and the antibacterial composite and all educts used for its preparation are non-toxic for human and environment. 2. Method for preparing an antibacterial composite comprising: a) a hydroxyapatite substrate, b) gold nanoparticles, and c) organic molecules, wherein the gold nahoparticles are attached to the hydroxyapatite substrate surface; the gold nanoparticles are covered by the organic molecules; the organic molecules are selected from the group consisting of amino acids and/or amines and/or thiols; the antibacterial composite and all educts used for its preparation are non-toxic for human and environment and the preparation is carried out by sonochemical precipitation.
法律状态
(WO2013187846) LEGAL DETAILS FOR WO2013187846  Actual or expected expiration date=2015-12-15    Legal state=DEAD    Status=LAPSED     Event publication date=2013-05-08  Event code=WO/APP  Event indicator=Pos  Event type=Examination events  Application details  Application country=WO WOSI2013000025  Application date=2013-05-08  Standardized application number=2013WO-SI00025     Event publication date=2013-12-19  Event code=WO/A1  Event type=Examination events  Published application with search report  Publication country=WO  Publication number=WO2013187846  Publication stage Code=A1  Publication date=2013-12-19  Standardized publication number=WO2013187846     Event publication date=2015-12-15  Event code=WO/EETL  Event type=Event indicating Not In Force  PCT Application validity period expired. LEGAL DETAILS FOR DESIGNATED STATE DE  Actual or expected expiration date=2014-12-15    Legal state=DEAD    Status=LAPSED   Corresponding cc:  Designated or member state=DE     Event publication date=2014-12-15  Event code=WO/NENP  Event type=Event indicating Not In Force  Non-entry into the national phase in: Corresponding cc:  Designated or member state=DE  LEGAL DETAILS FOR DESIGNATED STATE EP2863751  Actual or expected expiration date=2033-05-08    Legal state=ALIVE    Status=PENDING   Corresponding cc:  Designated or member state=EP Corresponding appl: EP13735469  Application date in the designated or member state=2013-05-08   Application number in the designated or member state=2013EP-0735469 Corresponding cc:  Designated or member state=EP Corresponding pat: EP2863751  Publication stage code in the designated or member state=A1  Publication date in the designated or member state=2015-04-29   Publication number in the designated or member state=EP2863751    Event publication date=2014-02-19  Event code=WO/121  Event type=Designated states  EP: The EPO has been informed by wipo that ep was designated in this application Corresponding cc:  Designated or member state=EP
专利类型码
A1
国别省市代码
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