耐​碳​青​霉​烯类​抗生素​病菌​的​荧光​探针​及合​成​方法​与​应用

源语言标题
(CN106279178) 耐​碳​青​霉​烯类​抗生素​病菌​的​荧光​探针​及合​成​方法​与​应用
公开号/公开日
CN106279178 A 2017-01-04 [CN106279178] / 2017-01-04
申请号/申请日
2016CN-0564289 / 2016-07-18
发明人
XIE HEXIN; MAO WUYU; XIA LINGYING
申请人
EAST CHINA UNIVERSITY OF SCIENCE & TECHNOLOGY
主分类号
IPC分类号
C07D-487/04;C09K-011/06;G01N-021/64
摘要
(CN106279178)
本​发明​的​耐​碳​青​霉​烯类​抗生素​病菌​的​荧光​探针​的​结构​通式​为:,在​结构​通式​中:X​为​碳原子​或​硫​原子;当​X​为​CH​时,R​为​甲基,能够​为​R​或​S​构型;或者​X​为​CH​或​S;Y​荧光​基团​芳香环​上​的​氧原子、硫​原子​或​连接​基团(linker),包括​4‑羟​甲基​苄​基​或​4‑羟基​或​巯​基​苄​基​或​氨基​甲酸​酯​连接​基团。所​述​荧光​探针​的​合成​方法​包括​以下​步骤:⑴​化合物​2​的​制备;⑵​中间体​3,4​的​制备;⑶​化合物​5​的​制备;⑷​化合物​6​的​制备;⑸)化合物​7​的​制备;⑹​化合物​8​的​制备;⑺​化合物​9​的​制备;⑻​化合物​10​的​制备;⑼​化合物​CPC‑1、即​荧光​探针​化合物​的​制备。本​发明​的​荧光​探针​可在​碳​青​霉​烯​酶​和​含有​碳​青​霉​烯​耐​药​菌​的​检测​中​应用,对在​医疗​中​不用​或​少用​抗生素​具有​重要​意义。
地址
代理人
代理机构
优先权号
2016CN-0564289 2016-07-18
主权利要求
(CN106279178)
1. Carbapenem antibiotic-resistant germs fluorescent probes, characterized in, of a fluorescent probe structure of the formula:
4. Carbapenem antibiotic-resistant pathogenic bacteria is a class of fluorescent probes, characterized in, Imipenem antibiotic glutamic acid as a fluorescent probe is the 3'-functionality having a leaving the introduction of fluorophores or chromophores, in a carbapenemase under the action of -lactam ring is opened, thereby releasing a fluorophore or chromophore groups, creation of a change in optical properties, for detecting the fluorescent probe has the properties of Carbapenem enzyme and its drug resistant bacteria, its structure is expressed as formula:
法律状态
(CN106279178)
LEGAL DETAILS FOR CN106279178

Actual or expected expiration date=2036-07-18   
Legal state=ALIVE   
Status=PENDING 



Event publication date=2016-07-18 
Event code=CN/APP 
Event indicator=Pos 
Event type=Examination events 
Application details

Application country=CN CN201610564289 
Application date=2016-07-18 
Standardized application number=2016CN-0564289 



Event publication date=2017-01-04 
Event code=CN/A 
Event type=Examination events 
Published application

Publication country=CN 
Publication number=CN106279178 
Publication stage Code=A 
Publication date=2017-01-04 
Standardized publication number=CN106279178 



Event publication date=2017-01-04 
Event code=CN/C06 
Event indicator=Pos 
Event type=Examination events 
Publication



Event publication date=2017-02-01 
Event code=CN/C10 
Event type=Examination events 
Request of examination as to substance
专利类型码
A
国别省市代码
必须先登录才能执行相关操作!

意见反馈
返回顶部