Composition for oral delivery of bioactive agents 机翻标题: 暂无翻译,请尝试点击翻译按钮。

源语言标题
(KR20160095124) 생물활성제의 경구 전달을 위한 조성물
公开号/公开日
KR20160095124 A 2016-08-10 [KR20160095124] / 2016-08-10
申请号/申请日
2016KR-7018181 / 2014-11-20
发明人
HAREL MOTI;KAMBALAPALLY SWETHA;
申请人
ADVANCED BIONUTRITION;
主分类号
IPC分类号
A61K-009/00A61K-009/16A61K-009/19A61K-009/50A61K-047/44
摘要
(KR20160095124) A process for selective transvinylation of a reactant carboxylic acid with a reactant vinyl ester to give a product vinyl ester and the corresponding acid of the reactant vinyl ester in the presence of one or more ruthenium catalysts, wherein a) the reactant vinyl ester, the reactant carboxylic acid and the ruthenium catalyst are supplied to a reactor, wherein b) the molar ratio of reactant vinyl ester to reactant carboxylic acid is 1:3 to 3:1, and c) the transvinylation reaction is conducted, d) on completion of the transvinylation reaction, the reactant vinyl ester and the corresponding acid are separated from the reaction mixture by distillation, e) the product vinyl ester is separated by distillation from the bottom product of the distillation, and f) the remaining reaction mixture is recycled into the reactor.  (From US2016296469 A1)
机翻摘要
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地址
代理人
代理机构
;
优先权号
2013US-61912958 2013-12-06 2014WO-US66510 2014-11-20
主权利要求
(KR20160095124)  1. The biology activator which is dispersed respectively to this oil drop (bioactive agent) as for under including to include the particle, the minute description oil drop to become, or chapter coating Polymer as for under including the hemp cloth being to a matrix [ting], depend, coating hereupon become, and the particle respectively this mucous membrane adhesive property Polymer (mucoadhesive polymer) in addition the low of including living in water kind or the composition for the oral medication of the biology activator to terrestrial kind. 2. There is in a 1st claim, and the composition where market coating Polymer builds a bridge. 3. Is in the second claim, the cross-linking reagent for market coating Polymer this the metal positive ion as for under including the composition. 4. The 1st claim to there is in which one claim in the 3rd claim, and the composition where mucous membrane adhesive property Polymer builds a bridge. 5. Is in the fourth claim, the temporary bridge combination with Tripoli force pay [thu] (association) to by from mucous membrane adhesive property Polymer the composition which is formed. 6. Is in the 1st claim to which one claim in the fifth claim, and the composition where mucous membrane adhesive property Polymer is dispersed to the oil drop. 7. There is in a 6th claim, and the composition where mucous membrane adhesive property Polymer and the biology activator are combined. 8. The 1st claim to there is in which one claim in the 7th claim, and the composition where the diameter of the particle is bigger 50 .micro.m. 9. The 1st claim to is in which one claim in the 8th claim, the biology activator the immunogen (immunogen) the composition. 10. The 1st claim to there is in which one claim in the 9th claim, and mucous membrane adhesive property Polymer Kara I, the derivative or the plasmodium of option in the chitosan, Hyaluronic Acid, egg Nate and such thing et cetera (modification), the car luck thread - Polymer and the sulfate which became action - Polymer, and the amine which became action - from the army which became accomplished with Polymer which had become action the composition which is more than one Polymer which is selected. 11. The 1st claim to there is in which one claim in the 10th claim, and market coating Polymer the pulley (maul [thu]) acryl rate, egg Nate, the pectin, the car diplopia methyl cellulose, the methyl cellulose and cellulose acetate [phu] from the army which became accomplished with the rate burn the composition which is more than one Polymer which is selected. 12. The 1st claim to there to be in which one claim in the 11th claim, the market coating Polymer matrix egg Nate and that maul of low viscosity grade the poetic pectin, or these union as for under including the composition. 13. The 1st claim to there is in which one claim in the 12th claim, and the oil region, from the army which became accomplished with the oil and the wax the composition which is more than one five works which are selected. 14. There is in a 13th claim, and the composition where the oil is the vegetability oil or animal five work. 15. Sequential, (a) is dispersed, the biology activator which is solved as for under including the hydrogenous blend at the time of formation as for height phase;   Will homogenize the hydrogenous blend of phased (a) to in (b) oils, to the hydrogenous blend in the oil will be distant, [cyen] at the time of formation as for height phase;   (c) chapter coating Polymer as for under including slurry of product of phased (b) in aqueous solution at the time of formation as for height phase.  And (D1) at the time of participle the height thing or, drops the slurry of phased (c) to the aqueous solution which contained the cross-linking reagent for market coating Polymer, and about under implanting forms the particle, the hydrogenous blend of phased (a) mucous membrane adhesive property Polymer in addition as for under including phase, or (d2) from the slurry of phased (c) forms the particle, phased (b) to in hydrogenous mucous membrane adhesive property Polymer will be distant, [cyen] viscosity adhesive property Polymer to form the drop to build a bridge, the intermediate particle at the time of formation as for height the thing in addition as for under including which one in phase as for under including, the first protest composition as for under manufacturing method. 16. Is in the 15th claim, phase (d1) the method which is accomplished. 17. Is in the 15th claim, phase (d2) the method which is accomplished. 18. There to be in a 17th claim, the particle at the time of formation as for height as for under the milling the phase freeze drying the product of phased (c) the thing as for under including method. 19. There is in a 17th claim, and the particle at the time of formation as for height the phase spraying constructing the product of phased (c) as for under including method. 20. To animal 9th protest composition as for under oral medicating phase as for under including, rear guard delivery of biology activator with animal (post gastric delivery) method. 21. Living in water kind or the 1st claim to which one protest composition in the 14th claim the low of oral medicating to include a phase, will be the delivery expense the composition for a vaccine to terrestrial kind and will grow, living in water kind or terrestrial kind as for under vaccine inoculating method.
法律状态
(KR20160095124) LEGAL DETAILS FOR KR20160095124  Actual or expected expiration date=2034-11-20    Legal state=ALIVE    Status=PENDING     Event publication date=2014-11-20  Event code=KR/APP  Event indicator=Pos  Event type=Examination events  Application details  Application country=KR KR20167018181  Application date=2014-11-20  Standardized application number=2016KR-7018181     Event publication date=2016-08-10  Event code=KR/A  Event type=Examination events  Published application  Publication country=KR  Publication number=KR20160095124  Publication stage Code=A  Publication date=2016-08-10  Standardized publication number=KR20160095124
专利类型码
A
国别省市代码
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