Poly (Vinyl Chloride) Matrix Membrane Sensors for the Quantification of Cyclizine Hydrochloride in Pure and Pharmaceutical Preparations
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Department of Chemistry, College of Science, Al-Nahrain University, Al-Jaderia, Baghdad-lraqDepartment of Chemistry, College of Science, Al-Nahrain University, Al-Jaderia, Baghdad-lraq
作者
Haneen A. Mohammed;Amina M. Abass
摘要
For the selective potentiometric a PVC membrane sensor was useful for determination of cyclizine with no preceding divorce or pretreatment. The suggested method is accurate, sensitive, precise and simple. It does not need any cultured. The sensors were prepared based on cyclizine (CYC) and phosphotungestic acid (TPA) ion-pair complex as the electro-active materials. Some of the selected plasticizers were used such as: Di-butyl phthalate (DBPH), Tri-n-butyl phosphate (TBP), O-Nitro Phenyl Octyl Ether (NPOE) in PVC matrix. The sensors parameters, linear range of concentration, Nemestian slope, limit of detection, response time, life time, and selectivity were evaluated. PH influence was also studied at different concentration for electrodes which depended on NPOE, DBPH, TBP as a plasticizers.
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