Association of Serum Vitamin D Concentration With Clinical Symptoms and Quality of Life in Patients With Irritable Bowel Syndrome 机翻标题: 暂无翻译,请尝试点击翻译按钮。

来源
Journal of the American College of Nutrition
年/卷/期
2019 / 38 / 4
页码
327-333
ISSN号
0731-5724
作者单位
Lorestan Univ Med Sci, Nutr Hlth Res Ctr, Dept Nutr, POB 6813833946, Khorramabad, Iran;Ahvaz Jundishapur Univ Med Sci, Hlth Res Inst Diabet Res Ctr, Dept Nutr, Ahwaz, Iran;Lorestan Univ Med Sci, Dept Pharmacol & Toxicol, Fac Pharm, Khorramabad, Iran;Lorestan Univ Med Sci, Nutr Hlth Res Ctr, Dept Nutr, POB 6813833946, Khorramabad, Iran;Ahvaz Jundishapur Univ Med Sci, Nutr & Metab Dis Researcher Ctr, Dept Nutr, Ahwaz, Iran;Lorestan Univ Med Sci, Nutr Hlth Res Ctr, Dept Nutr, POB 6813833946, Khorramabad, Iran;Lorestan Univ Med Sci, Nutr Hlth Res Ctr, Dept Nutr, POB 6813833946, Khorramabad, Iran;
作者
Abbasnezhad, Amir;Amani, Reza;Hasanvand, Amin;Rad, Esmaeil Yousefi;Alipour, Meysam;Saboori, Somayeh;Choghakhori, Razieh;
摘要
Objective: A high prevalence of vitamin D deficiency (VDD) in gastrointestinal (GI) disorders and the role of vitamin D in the function of the gut have been shown previously. Therefore, we aimed to evaluated the VDD and the possible association of the GI symptoms severity and quality of life (QoL) score with the serum levels of vitamin D in irritable bowel syndrome (IBS). Methods: A total of 90 patients with IBS based on Rome III criteria enrolled in the study from the tertiary referral university hospital. In addition, 90 sex- and age-matched healthy controls (HCs) were recruited. To measure the serum levels of 25(OH)D-3, blood samples were taken from all the participants. Severity of clinical symptoms, IBS quality of life (IBS-QoL), and IBS symptom severity score (IBSSS) were assessed. Results: In 66.7% of IBS patients, serum 25(OH)D-3 concentrations were <20 ng/mL. The mean serum 25(OH)D-3 of IBS patients was statistically (p < 0.05) lower vs. HCs. When different subtypes were analyzed, the serum 25(OH)D-3 concentrations in diarrhea-predominant IBS were statistically (p < 0.05) lower as compared to HCs. Furthermore, the lower serum concentrations of 25(OH)D-3 were associated (p < 0.05) with higher severity of abdominal pain and distention, flatulence, overall GI symptoms, and IBSSS. However, a direct significant association was seen between IBS-QoL and serum 25(OH)D-3. Conclusion: Results of this study showed a high prevalence of VDD in patients with IBS. In addition, VDD was associated with a higher severity of clinical symptoms and lower QoL in IBS.
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关键词/主题词
Irritable bowel syndrome;vitamin D;vitamin D deficiency;clinical symptoms;health-related quality of life;IBS severity score;
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